Summary of main observation and conclusion A vible light driven Cu()-catalyzed intermolecular oxyamination of electron-deficient olefins has been achieved by using O-benzoylhydroxylamines as donors both for amine and ...Summary of main observation and conclusion A vible light driven Cu()-catalyzed intermolecular oxyamination of electron-deficient olefins has been achieved by using O-benzoylhydroxylamines as donors both for amine and oxygen.The transformation properties afford mild conditions and a wide substrate scope,providing access to ester derivatives of 6-amino alcohols with good yields and high regioselectivity.展开更多
A highly enantioselective gold-catalyzed intermolecular[3+2]cycloaddition of N-allenamides with nitrones was realized by the application of Ming-Phos M6 as a chiral ligand.Both enantiomers of the cycloadducts with opp...A highly enantioselective gold-catalyzed intermolecular[3+2]cycloaddition of N-allenamides with nitrones was realized by the application of Ming-Phos M6 as a chiral ligand.Both enantiomers of the cycloadducts with opposite configuration could be obtained in high yields with high regio-and enantioselectivity by the employment of either diastereomer of the chiral ligand.The acidic N—H bond(hydrogen bonding)of sulfinamide moiety of Ming-Phos and pentaflurophenyl substituent(fluorine effect)may play important roles in enhancement of enantioselectivity,that is,Ming-Phos is a multifunctional ligand in this transformation.展开更多
Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-quadruplexes.The p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines wer...Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-quadruplexes.The p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines were identified to give the strongest fluorescence with the formation of G_(8)-octamers(G_(8))both in solution(NMR)and solid state(X-ray).This well-defined G_(8)-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission(AIE),which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.展开更多
基金We are grateful to the Shanghai Sailing Program(No.16YF1402800)the 973 programs(No.2015CB856600)the National Natural Science Foundation of China(No.21425205)。
文摘Summary of main observation and conclusion A vible light driven Cu()-catalyzed intermolecular oxyamination of electron-deficient olefins has been achieved by using O-benzoylhydroxylamines as donors both for amine and oxygen.The transformation properties afford mild conditions and a wide substrate scope,providing access to ester derivatives of 6-amino alcohols with good yields and high regioselectivity.
基金the National Key R&D Program of China 2021YFF0701600)the National Natural Science Foundation of China(22031004,21921003,21801078,22071060)Shanghai Municipal Education Commission(20212308).
文摘A highly enantioselective gold-catalyzed intermolecular[3+2]cycloaddition of N-allenamides with nitrones was realized by the application of Ming-Phos M6 as a chiral ligand.Both enantiomers of the cycloadducts with opposite configuration could be obtained in high yields with high regio-and enantioselectivity by the employment of either diastereomer of the chiral ligand.The acidic N—H bond(hydrogen bonding)of sulfinamide moiety of Ming-Phos and pentaflurophenyl substituent(fluorine effect)may play important roles in enhancement of enantioselectivity,that is,Ming-Phos is a multifunctional ligand in this transformation.
基金the National Natural Science Founda-tion(No.CHE-1665122)the National Institutes of Health(No.1R01GM 120240-01)for financial support.
文摘Fluorescence(FL)active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G_(8)-quadruplexes.The p-cyano(p-CN)and 8-anthracene(8-An)substituted guanosines were identified to give the strongest fluorescence with the formation of G_(8)-octamers(G_(8))both in solution(NMR)and solid state(X-ray).This well-defined G_(8)-octamer system has provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission(AIE),which could be applied as the foundation for FL molecular probe design toward G-quadruplex recognition.
