A 3D Matching Method for Organic Training Samples Alignment Based on Surface Curvature Distribution

The fundamental step to get a Statistical Shape Model (SSM) is to align all the training samples to the same spatial modality. In this paper, we propose a new 3D alignment method for organic training samples matching, whose modalities are orientable and surface figures could be recognized. It is a feature based alignment method which matches two models depending on the distribution of surface curvature. According to the affine transformation on 2D Gaussian map, the distances between the corresponding parts on surface could be minimized. We applied our proposed method on 5 cases left lung training samples alignment and 4 cases liver training samples alignment. The experiment results were performed on the left lung training samples and the liver training samples. The availability of proposed method was confirmed.

Facile synthesis and electrochemical properties of layered Li[Ni1/3Mn1/3Co1/3]O2 as cathode materials for lithium-ion batteries

A layered oxide Li[Ni1/3Mn1/3Co1/3]O2 was synthesized by an oxalate co- precipitation method. The morphology, structural and composition of the as-papered samples synthesized at different calcination temperatures were investigated. The results indicate that calcination temperature of the sample at 850℃ can improve the integrity of structural significantly. The effect of calcination temperature varying from 750℃ to 950℃ on the electrochemical performance of Li[Ni1/3Mn1/3Co1/3]O2, cathode material of lithiumion batteries, has been investigated. The results show that Li[Ni1/3Mn1/3Co1/3]O2 calcined at 850℃ possesses a higher capacity retention and better rate capability than other samples. The reversible capacity is up to 178.6 mA.h.g-1, and the discharge capacity still remains 176.3 mA-h.g-1 after 30 cycles. Moreover, our strategy provides a simple and highly versatile route in fabricating cathode materials for lithium-ion batteries.

VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts

Previous research on tissue-engineered blood vessels(TEBVs)has mainly focused on the intima or adventitia unilaterally,neglecting the equal importance of both layers.Meanwhile,the efficacy of grafts modified with vascular endothelial growth factor(VEGF)merely has been limited.Here,we developed a small-diameter graft that can gradually release VEGF andγsecretase inhibitor IX(DAPT)to enhance tissue regeneration and remodeling in both the intima and adventitia.In vitro,experiments revealed that the combination of VEGF and DAPT had superior pro-proliferation and pro-migration effects on endothelial cells.In vivo,the sustained release of VEGF and DAPT from the grafts resulted in improved regeneration and remodeling.Specifically,in the intima,faster endothelialization and regeneration of smooth muscle cells led to higher patency rates and better remodeling.In the adventitia,a higher density of neovascularization,M2 macrophages and fibroblasts promoted cellular ingrowth and replacement of the implant with autologous neo-tissue.Furthermore,western blot analysis confirmed that the regenerated ECs were functional and the effect of DAPT was associated with increased expression of vascular endothelial growth factor receptor 2.Our study demonstrated that the sustained release of VEGF and DAPT from the graft can effectively promote tissue regeneration and remodeling in both the intima and adventitia.This development has the potential to significantly accelerate the clinical application of small-diameter TEBVs.

基于共聚焦显微镜图像拼接方法分析干眼患者角膜神经形态

目的:探讨使用活体共聚焦显微镜(IVCM)角膜神经图像拼接方法分析干眼患者角膜神经形态特点及其与干眼临床指标的相关性。方法:系列病例研究。收集2021年1─5月于北京大学人民医院眼科就诊的干眼患者16例(16眼)。所有患者均进行无创伤泪河高度(NITMH)、无创伤泪膜破裂时间(NITBUT)、荧光素染色泪膜破裂时间(TBUT)、角膜荧光素染色(FL)评分、睑板腺缺失比例、基础泪液分泌试验(SⅠT)、IVCM等检查。分别使用传统方法和新的拼接图像处理方法分析患者角膜上皮下神经图像面积、神经总长度、神经密度、平均神经长度、最长神经长度、最短神经长度、神经数量、神经数量密度等指标。纳入右眼数据进行分析。2种方法间角膜神经分析的数据比较采用wilcoxon秩和检验。干眼临床指标与角膜神经分析数据的相关性采用Spearman相关性分析。结果:新的拼接图像分析方法在角膜上皮下神经图像面积、神经总长度、神经密度、平均神经长度、最长神经长度、神经数量方面均明显大于传统分析方法(均P<0.05);最短神经长度较传统分析方法短(P<0.001);神经数量密度较传统方法比较差异无统计学意义。使用传统分析方法时,NIKBUT与平均神经长度、神经数量、神经数量密度均有相关性(r=0.52,P=0.037;r=-0.62,P=0.011;r=-0.62,P=0.011),其余干眼指标与角膜神经指标均无相关性。而使用拼接图像分析方法时,NIKBUT与平均神经密度呈负相关(r=-0.56,P=0.025),其余干眼指标与角膜神经指标均无相关性。结论:相比传统分析方法,新的拼接图像分析方法可获得更大角膜神经分析面积。2种分析方法的角膜神经分析结果不同,部分干眼指标与角膜神经分析结果的相关性也不同。新的共聚焦显微镜图像拼接分析方法能够更准确、更可靠地评估干眼患者角膜上皮下神经情况。

Mantle Source Components and Magmatic Evolution for the Comei Large Igneous Province:Evidence from the Early Cretaceous Niangzhong Mafic Magmatism in Tethyan Himalaya

The Niangzhong diabase dikes,dated at 138.1±0.4 Ma,are located within the outcrop area of the Comei large igneous province(LIP).These diabase samples can be divided into two groups:samples in Group 1 show varying MgO(1.50 wt.%-10.25 wt.%)and TiO_(2)(0.85 wt.%-4.63 wt.%)contents,and enriched initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7056-0.7112,ε_(Nd)(t)=-0.3-+3.8),with OIB-like REEs and trace elements patterns,resulting from low degree melting of garnet-bearing lherzolite mantle sources;in contrast,samples in Group 2 show limited MgO(4.14 wt.%-7.75 wt.%)and TiO_(2)(0.98 wt.%-1.69 wt.%)contents,and depleted initial isotope compositions(^(87)Sr/^(86)Sr(t)=0.7075-0.7112,ε_(Nd)(t)=+5.5-+6.2),with N-MORB-like REEs and trace elements patterns,resulting from relatively high degree melting of spinel-bearing lherzolite mantle source.Combined with the published representative data about Comei LIP,we summarize that the source components for Comei LIP products include OIB end-member,enriched OIB end-member,and N-MORB end-member,respectively.Melts modeling suggests that magmas in the Comei LIP evolve in a relatively high oxygen fugacity condition,which influenced their fractionation sequences and led to systematic changes of TiO_(2)contents,Ti/Y and Ti/Ti*ratios.From the spatial and temporal distribution of above three end-member samples,deep process of Kerguelen plume during the Comei LIP formation can be interpreted as the interaction among the Kerguelen plume,the overlying lithospheric mantle,and the upwelling asthenosphere.The magmatism of Comei LIP began at~140 Ma and then lasted and peaked at~132 Ma with the progressively lithospheric thinning of eastern Gondwana upon the impact of Kerguelen plume.