Objective: This study aims to evaluate the safety and efficacy of PETD combined with nerve root water imaging of MRI for the treatment of lumbar disc herniation. Methods: A retrospective review was performed on 62 pat...Objective: This study aims to evaluate the safety and efficacy of PETD combined with nerve root water imaging of MRI for the treatment of lumbar disc herniation. Methods: A retrospective review was performed on 62 patients with lumbar disc herniation from March 2019 to March 2021. The study included an experimental group of 30 patients and a control group of 32 patients. The experimental group underwent PETD combined with nerve root water imaging of MRI, while the control group received traditional PETD treatment. The visual analogue scoring method (VAS score), and JOA lumbar spine function score before and after surgery were compared between the two groups, and efficacy was assessed and compared using the MacNab score. Results: The mean operation time was significantly reduced in the experimental group (56.43 ±10.40 minutes) compared to the control group (65.69 ±14.12 minutes). The VAS score was compared between the two groups with preoperative (p = 0.624), one month after surgery (p = 0.325), three months after surgery (p = 0.676), one year after surgery (p = 0.341);The JOA score was compared between the two groups with preoperative (p = 0.961), one month after the surgery (p = 0.266), three months after surgery (p = 0.185), one year after surgery (p = 0.870), they were no significant statistical difference;The efficacy evaluation of the last follow-up Macnab showed that all the 30 patients in the experimental group were excellent, 31 of 32 patients in the control group were excellent, 1 case was good;There was no statistical difference in the comparison between the two groups (p > 0.05). Conclusion: The study concludes that the combined approach of PETD with nerve root water imaging of MRI is a safe, effective, and more efficient alternative to conventional PETD for treating lumbar disc herniation.展开更多
The concept of integrated forest biorefineries(IFBRs) has gained significant interest.The prehydrolysis kraft(PHK) dissolving pulp production process is a suitable example of IFBR concept for the production of dissolv...The concept of integrated forest biorefineries(IFBRs) has gained significant interest.The prehydrolysis kraft(PHK) dissolving pulp production process is a suitable example of IFBR concept for the production of dissolving pulp and utilization of dissolved hemicelluloses,acetic acid,and lignin in the prehydrolysis liquor(PHL).This review paper highlights recent progress related to the recovery and utilization of dissolved organics(e.g.,hemicelluloses,acetic acid,and lignin) in the PHL of the PHK dissolving pulp production process.Integrated multi-step recovery and separation processes have been developed for this purpose to accommodate the complex nature of the PHL.Potential products,including xylan-based compounds,acetic acid,and lignin,are also discussed in detail.展开更多
In this study,corn stalk was pretreated by steam explosion under various processing conditions,and the antioxidant activity of hydrolysates in the post-process washing liquor was analyzed using the 1,1'-diphenyl-2...In this study,corn stalk was pretreated by steam explosion under various processing conditions,and the antioxidant activity of hydrolysates in the post-process washing liquor was analyzed using the 1,1'-diphenyl-2-picrylhydrazyl(DPPH•)scavenging method.The yield and composition of the hydrolysates obtained under different treatment conditions were also determined;the results indicated that the steam explosion extent had a significant effect on both properties.Under optimized conditions(1.5 MPa,20 min),the obtained hydrolysate had the highest phenolic compound yield(18.6 mg/g untreated corn stalk)and the highest radical scavenging capacity(IC_(50)=0.24 mg/mL).To confirm the positive effect of phenolic compounds on the antioxidant activity of the hydrolysate,one-step ethanol fractionation was carried out.Due to the enrichment of phenolic compounds,the ethanolsoluble fraction(ESF)exhibited significantly enhanced antioxidant activity with an IC_(50) value of 0.06 mg/mL,which was close to that of butylated hydroxytoluene(BHT,IC_(50)=0.056 mg/mL).Consequently,this work indicated that phenolic compounds have a significant effect on the antioxidant activity of hydrolysate from steam-exploded corn stalk and that simple one-step ethanol fractionation is an effective way to enrich the phenolic compounds in the hydrolysate and improve the antioxidant activity.展开更多
A new dual-actuator fatigue loading system of wind turbine blades was designed.Compared with the traditional pendulum loading mode,the masses in this system only moved linearly along the loading direction to increase ...A new dual-actuator fatigue loading system of wind turbine blades was designed.Compared with the traditional pendulum loading mode,the masses in this system only moved linearly along the loading direction to increase the exciting force.However,the two actuators and the blade constituted a complicated non-linear energy transferring system,which led to the non-synchronization of actuators.On-site test results showed that the virtual spindle synchronous strategy commonly used in synchronous control was undesirable and caused the instability of the blade’s amplitude eventually.A cross-coupled control strategy based on the active disturbance rejection algorithm was proposed.Firstly,a control system model was built according to the synchronization error and tracking error.Furthermore,based on arranging the transition process,estimating the system state and error feedback,and compensating disturbance,an active disturbance rejection controller was designed by adopting the optimal control function.Finally,on-site test results showed that the cross-coupled control strategy based on the active disturbance rejection algorithm could ensure the synchronization of two actuators.The maximum speed synchronization error of the two motors was less than 16 RPM,the displacement synchronization error of the two actuators was less than 0.25 mm and approaching zero after 4 seconds,and the peak value of vibration of the blade was less than 5 mm,which satisfied the fatigue test requirement.展开更多
The morphological characteristics and growth habits of medicinal chrysanthemums are described,the cultivation techniques are summarized from the aspects of nursery,transplanting and field management,and the harvest an...The morphological characteristics and growth habits of medicinal chrysanthemums are described,the cultivation techniques are summarized from the aspects of nursery,transplanting and field management,and the harvest and primary processing technology are introduced in detail.展开更多
This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin(CSF)scaffolds on the proliferation and differentiation of human dental pulp cells(HDPCs).The CSF scaffolds were designe...This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin(CSF)scaffolds on the proliferation and differentiation of human dental pulp cells(HDPCs).The CSF scaffolds were designed with 3D mapping software Solidworks.Three different aperture-sized scaffolds(CSF1-CSF3)were prepared by low-temperature deposition 3D printing technology.The morphology was observed by scanning electron microscope(SEM)and optical coherence tomography.The porosity,hydrophilicity and mechanical capacity of the scaffold were detected,respectively.HDPCs(third passage,1105 cells)were seeded into each scaffold and investigated by SEM,CCK-8,alkaline phosphatase(ALP)activity and HE staining.The CSF scaffolds had porous structures with macropores and micropores.The macropore size of CSF1 to CSF3 was 421627 lm,579636 lm and 707643 lm,respectively.The porosity was 69.862.2%,80.162.8%and 86.563.3%,respectively.All these scaffolds enhanced the adhesion and proliferation of HDPCs.The ALP activity in the CSF1 group was higher than that in the CSF3 groups(P<0.01).HE staining showed HDPCs grew in multilayer within the scaffolds.CSF scaffolds significantly improved the adhesion and ALP activity of HDPCs.CSF scaffolds were promising candidates in dentine-pulp complex regeneration.展开更多
Amelogenin can induce odontogenic differentiation of human dental pulp cells(HDPCs),which has great potential and advantages in dentine-pulp complex regeneration.However,the unstability of amelogenin limits its furthe...Amelogenin can induce odontogenic differentiation of human dental pulp cells(HDPCs),which has great potential and advantages in dentine-pulp complex regeneration.However,the unstability of amelogenin limits its further application.This study constructed amelogenin self-assembling peptide hydrogels(L-gel or D-gel)by heating-cooling technique,investigated the effects of these hydrogels on the odontogenic differentiation of HDPCs and explored the underneath mechanism.The critical aggregation concentration,conformation,morphology,mechanical property and biological stability of the hydrogels were characterized,respectively.The effects of the hydrogels on the odontogenic differentiation of HDPCs were evaluated via alkaline phosphatase activity measurement,quantitative reverse transcription polymerase chain reaction,western blot,Alizarin red staining and scanning electron microscope.The mechanism was explored via signaling pathway experiments.Results showed that both the L-gel and D-gel stimulated the odontogenic differentiation of HDPCs on both Day 7 and Day 14,while the D-gel showed the highest enhancement effects.Meanwhile,the D-gel promoted calcium accumulation and mineralized matrix deposition on Day 21.The D-gel activated MAPK-ERK1/2 pathways in HDPCs and induced the odontogenic differentiation via ERK1/2 and transforming growth factor/smad pathways.Overall,our study demonstrated that the amelogenin peptide hydrogel stimulated the odontogenic differentiation and enhanced mineralization,which held big potential in the dentine-pulp complex regeneration.展开更多
文摘Objective: This study aims to evaluate the safety and efficacy of PETD combined with nerve root water imaging of MRI for the treatment of lumbar disc herniation. Methods: A retrospective review was performed on 62 patients with lumbar disc herniation from March 2019 to March 2021. The study included an experimental group of 30 patients and a control group of 32 patients. The experimental group underwent PETD combined with nerve root water imaging of MRI, while the control group received traditional PETD treatment. The visual analogue scoring method (VAS score), and JOA lumbar spine function score before and after surgery were compared between the two groups, and efficacy was assessed and compared using the MacNab score. Results: The mean operation time was significantly reduced in the experimental group (56.43 ±10.40 minutes) compared to the control group (65.69 ±14.12 minutes). The VAS score was compared between the two groups with preoperative (p = 0.624), one month after surgery (p = 0.325), three months after surgery (p = 0.676), one year after surgery (p = 0.341);The JOA score was compared between the two groups with preoperative (p = 0.961), one month after the surgery (p = 0.266), three months after surgery (p = 0.185), one year after surgery (p = 0.870), they were no significant statistical difference;The efficacy evaluation of the last follow-up Macnab showed that all the 30 patients in the experimental group were excellent, 31 of 32 patients in the control group were excellent, 1 case was good;There was no statistical difference in the comparison between the two groups (p > 0.05). Conclusion: The study concludes that the combined approach of PETD with nerve root water imaging of MRI is a safe, effective, and more efficient alternative to conventional PETD for treating lumbar disc herniation.
文摘The concept of integrated forest biorefineries(IFBRs) has gained significant interest.The prehydrolysis kraft(PHK) dissolving pulp production process is a suitable example of IFBR concept for the production of dissolving pulp and utilization of dissolved hemicelluloses,acetic acid,and lignin in the prehydrolysis liquor(PHL).This review paper highlights recent progress related to the recovery and utilization of dissolved organics(e.g.,hemicelluloses,acetic acid,and lignin) in the PHL of the PHK dissolving pulp production process.Integrated multi-step recovery and separation processes have been developed for this purpose to accommodate the complex nature of the PHL.Potential products,including xylan-based compounds,acetic acid,and lignin,are also discussed in detail.
基金This work was kindly funded by National Natural Science Foundation of China(32071721)Research and Development Plan of Key Areas in Hu'nan Province(2019NK2032).
文摘In this study,corn stalk was pretreated by steam explosion under various processing conditions,and the antioxidant activity of hydrolysates in the post-process washing liquor was analyzed using the 1,1'-diphenyl-2-picrylhydrazyl(DPPH•)scavenging method.The yield and composition of the hydrolysates obtained under different treatment conditions were also determined;the results indicated that the steam explosion extent had a significant effect on both properties.Under optimized conditions(1.5 MPa,20 min),the obtained hydrolysate had the highest phenolic compound yield(18.6 mg/g untreated corn stalk)and the highest radical scavenging capacity(IC_(50)=0.24 mg/mL).To confirm the positive effect of phenolic compounds on the antioxidant activity of the hydrolysate,one-step ethanol fractionation was carried out.Due to the enrichment of phenolic compounds,the ethanolsoluble fraction(ESF)exhibited significantly enhanced antioxidant activity with an IC_(50) value of 0.06 mg/mL,which was close to that of butylated hydroxytoluene(BHT,IC_(50)=0.056 mg/mL).Consequently,this work indicated that phenolic compounds have a significant effect on the antioxidant activity of hydrolysate from steam-exploded corn stalk and that simple one-step ethanol fractionation is an effective way to enrich the phenolic compounds in the hydrolysate and improve the antioxidant activity.
基金the National Key R&D Program of China,Grant No.2018YFB1501203Meanwhile,this research was funded by the Natural Science Foundation of Shandong,Grant No.ZR2019MEE076And the work in this paper has partly received funding from the National Key R&D Program of Shandong,Grant No.2019GGX104001.
文摘A new dual-actuator fatigue loading system of wind turbine blades was designed.Compared with the traditional pendulum loading mode,the masses in this system only moved linearly along the loading direction to increase the exciting force.However,the two actuators and the blade constituted a complicated non-linear energy transferring system,which led to the non-synchronization of actuators.On-site test results showed that the virtual spindle synchronous strategy commonly used in synchronous control was undesirable and caused the instability of the blade’s amplitude eventually.A cross-coupled control strategy based on the active disturbance rejection algorithm was proposed.Firstly,a control system model was built according to the synchronization error and tracking error.Furthermore,based on arranging the transition process,estimating the system state and error feedback,and compensating disturbance,an active disturbance rejection controller was designed by adopting the optimal control function.Finally,on-site test results showed that the cross-coupled control strategy based on the active disturbance rejection algorithm could ensure the synchronization of two actuators.The maximum speed synchronization error of the two motors was less than 16 RPM,the displacement synchronization error of the two actuators was less than 0.25 mm and approaching zero after 4 seconds,and the peak value of vibration of the blade was less than 5 mm,which satisfied the fatigue test requirement.
文摘The morphological characteristics and growth habits of medicinal chrysanthemums are described,the cultivation techniques are summarized from the aspects of nursery,transplanting and field management,and the harvest and primary processing technology are introduced in detail.
基金This work was supported by the Natural Science Foundation of Tianjin City of China(grant number 18JCYBJC27000)the National Natural Science Foundation of China(grant number 11972198)+2 种基金the State Key Laboratory of Medicinal Chemical Biology(grant number 2018012)the Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction(grant number KFKT2017008)the Tianjin Health and Family Planning Commission of the People’s Republic of China(grant numbers ZD20016,2014KY24 and 2015KY23).
文摘This study aimed at evaluate the effects of different aperture-sized type I collagen/silk fibroin(CSF)scaffolds on the proliferation and differentiation of human dental pulp cells(HDPCs).The CSF scaffolds were designed with 3D mapping software Solidworks.Three different aperture-sized scaffolds(CSF1-CSF3)were prepared by low-temperature deposition 3D printing technology.The morphology was observed by scanning electron microscope(SEM)and optical coherence tomography.The porosity,hydrophilicity and mechanical capacity of the scaffold were detected,respectively.HDPCs(third passage,1105 cells)were seeded into each scaffold and investigated by SEM,CCK-8,alkaline phosphatase(ALP)activity and HE staining.The CSF scaffolds had porous structures with macropores and micropores.The macropore size of CSF1 to CSF3 was 421627 lm,579636 lm and 707643 lm,respectively.The porosity was 69.862.2%,80.162.8%and 86.563.3%,respectively.All these scaffolds enhanced the adhesion and proliferation of HDPCs.The ALP activity in the CSF1 group was higher than that in the CSF3 groups(P<0.01).HE staining showed HDPCs grew in multilayer within the scaffolds.CSF scaffolds significantly improved the adhesion and ALP activity of HDPCs.CSF scaffolds were promising candidates in dentine-pulp complex regeneration.
基金supported by the National Science Fund for Excellent Young Scholars(T2122019)the National Natural Science Foundation of China(51973096,51773097)+4 种基金the Natural Science Foundation of Tianjin City(18JCYBJC27000)the Technology Research and Development Program of Tianjin(20YFZCSY00830)the Tianjin Key Medical Discipline(Specialty)Construction Project(2021-516)the Science and Technology Project of Tianjin Health Commission(ZD20016)the Key Laboratory of Bioactive Materials,Ministry of Education(NKBM-2019-001,NKBM-2019-002).
文摘Amelogenin can induce odontogenic differentiation of human dental pulp cells(HDPCs),which has great potential and advantages in dentine-pulp complex regeneration.However,the unstability of amelogenin limits its further application.This study constructed amelogenin self-assembling peptide hydrogels(L-gel or D-gel)by heating-cooling technique,investigated the effects of these hydrogels on the odontogenic differentiation of HDPCs and explored the underneath mechanism.The critical aggregation concentration,conformation,morphology,mechanical property and biological stability of the hydrogels were characterized,respectively.The effects of the hydrogels on the odontogenic differentiation of HDPCs were evaluated via alkaline phosphatase activity measurement,quantitative reverse transcription polymerase chain reaction,western blot,Alizarin red staining and scanning electron microscope.The mechanism was explored via signaling pathway experiments.Results showed that both the L-gel and D-gel stimulated the odontogenic differentiation of HDPCs on both Day 7 and Day 14,while the D-gel showed the highest enhancement effects.Meanwhile,the D-gel promoted calcium accumulation and mineralized matrix deposition on Day 21.The D-gel activated MAPK-ERK1/2 pathways in HDPCs and induced the odontogenic differentiation via ERK1/2 and transforming growth factor/smad pathways.Overall,our study demonstrated that the amelogenin peptide hydrogel stimulated the odontogenic differentiation and enhanced mineralization,which held big potential in the dentine-pulp complex regeneration.