Antimicrobial resistance(AMR)remains an urgent and formidable challenge to global public health.Developing new medicines or alternative therapies to address AMR is imperative.Herein,we rationally designed and synthesi...Antimicrobial resistance(AMR)remains an urgent and formidable challenge to global public health.Developing new medicines or alternative therapies to address AMR is imperative.Herein,we rationally designed and synthesized a series of Au(I)-based aggregation-induced emission luminogens(AIEgens)to combat drug-resistant bacterial infections.Through systematic screening,we identified an optimal AIEgen,called complex 5,which can rapidly discriminate between gram-positive(G^(+))and gram-negative bacteria(G^(-))bacteria,and exert robust and broad-spectrum antimicrobial potency against diverse drug-resistant bacterial strains,including those intractable to treat in clinic.Furthermore,extensive testing against a variety of clinical drug-resistant isolates,coupled with the successful treatment of methicillin-resistant Staphylococcus aureus-infected skin wounds unequivocally validates the high efficiency and broad-spectrum activity of complex 5.Therefore,complex 5 emerges as a promising candidate for combating drug-resistant bacterial infections in clinic,and this work provides inspiration for developing new solutions to address the escalating global challenge of AMR.展开更多
基金Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Numbers:2021A1515110373,2023A1515011924Science and Technology Planning Project of Guangzhou-Basic and Applied Basic Research Project,Grant/Award Number:202201011505+4 种基金Major Scientific and Technological Special Project in the Precision Medical Field of Guangdong Province,Grant/Award Number:2019B020232003National Key Research and Development Program of China,Grant/Award Numbers:2021YFA1300604,2021YFE0202400National Natural Science Foundation of China,Grant/Award Numbers:22205096,31971293Outstanding Youths Development Scheme of Nanfang Hospital,Southern Medical University,Grant/Award Number:2021J002National Science Fund for Distinguished Young Scholars,Grant/Award Number:82025024。
文摘Antimicrobial resistance(AMR)remains an urgent and formidable challenge to global public health.Developing new medicines or alternative therapies to address AMR is imperative.Herein,we rationally designed and synthesized a series of Au(I)-based aggregation-induced emission luminogens(AIEgens)to combat drug-resistant bacterial infections.Through systematic screening,we identified an optimal AIEgen,called complex 5,which can rapidly discriminate between gram-positive(G^(+))and gram-negative bacteria(G^(-))bacteria,and exert robust and broad-spectrum antimicrobial potency against diverse drug-resistant bacterial strains,including those intractable to treat in clinic.Furthermore,extensive testing against a variety of clinical drug-resistant isolates,coupled with the successful treatment of methicillin-resistant Staphylococcus aureus-infected skin wounds unequivocally validates the high efficiency and broad-spectrum activity of complex 5.Therefore,complex 5 emerges as a promising candidate for combating drug-resistant bacterial infections in clinic,and this work provides inspiration for developing new solutions to address the escalating global challenge of AMR.
