The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 w...The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.展开更多
目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。...目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。溶媒对照组给予0.9%氯化钠注射液,实验组分别给予2B11100和400 mg·kg^(-1)。每隔6 d iv给药1次,2周共给药3次,停药后恢复9周。实验期间进行一般症状观察、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、系统解剖、脏器系数、组织病理学和免疫学检测,同时进行抗药抗体(ADA)及血药浓度检测,并分析毒代动力学参数。结果实验期间2B112个剂量组恒河猴一般症状、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、脏器系数、组织病理学和免疫学检测等指标均未见与受试物有关的明显改变。2B112个剂量组均未检测到ADA,血浆药物浓度变化基本一致,且与给药剂量呈正比,峰浓度之比和暴露量之比也与给药剂量呈正比,2B11注射液在体内基本呈线性动力学特征。结论在本实验条件下,恒河猴2周重复iv给予2B113次是安全的,400 mg·kg^(-1)未观察到临床不良反应。展开更多
In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent ja...In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent jamming problem in a multi-user scenario, where the coordination between the jammers is considered. Firstly, a multi-agent Markov decision process (MDP) framework is used to model and analyze the multi-agent jamming problem. Secondly, a collaborative multi-agent jamming algorithm (CMJA) based on reinforcement learning is proposed. Finally, an actual intelligent jamming system is designed and built based on software-defined radio (SDR) platform for simulation and platform verification. The simulation and platform verification results show that the proposed CMJA algorithm outperforms the independent Q-learning method and provides a better jamming effect.展开更多
Xibe Language exhibits a considerable amount of phonetic variation and complexity.Although the phonetic changes in Xibe Language do not serve a distinguishing purpose in the flow of speech,they reflect the phonetic ch...Xibe Language exhibits a considerable amount of phonetic variation and complexity.Although the phonetic changes in Xibe Language do not serve a distinguishing purpose in the flow of speech,they reflect the phonetic characteristics of the language,thus affecting people's normal communication to a certain extent.Based on field survey data collected in the Xibe people who lives in Qabqaal Xibe Autonomous County,Xinjiang,the author analyzes the phonetic changes and summarizes the patterns of phonetic variation of Xibe Languag.展开更多
The Neogene is an important period for studying the onset of subduction,with numerous subduction zones forming in the western Pacific,including the Ryukyu,Manila,Philippine,North Sulawesi,Halmahera,New Britain,Solomon...The Neogene is an important period for studying the onset of subduction,with numerous subduction zones forming in the western Pacific,including the Ryukyu,Manila,Philippine,North Sulawesi,Halmahera,New Britain,Solomon,and New Hebrides subduction zones.However,studies on these subduction zones are relatively independent,so it is important to conduct systematic comparative studies.In this paper,we review the initiation models of Neogene subduction in the western Pacific,with the three typical types of subduction initiation models including polarity-reversal,induced subduction re-initiation,and noninherited subduction initiation to form new ruptures.In addition,the parameters of different subduction zones are collated to form five categories:basic features,subducting plate features,upper plate features,kinematic features,and subsequent activity.The regularity of the subduction processes,the specificity of the different subduction cases,and the possible constraints between the subduction initiation types and the characteristics of the subduction zone parameters are discussed and analyzed.The compiled dataset of the subduction zone parameters can provide data support for related studies.展开更多
基金supported by National Basic Research Program of China(2010CB834202)the National Natural Science Foundation of China(11305226,11175222)+1 种基金the Scientific Technology Research Projects of Lanzhou City(2015-3-75)the Western Talent Program of Chinese Academy of Sciences(Y460030XB0)
文摘The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.
文摘目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。溶媒对照组给予0.9%氯化钠注射液,实验组分别给予2B11100和400 mg·kg^(-1)。每隔6 d iv给药1次,2周共给药3次,停药后恢复9周。实验期间进行一般症状观察、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、系统解剖、脏器系数、组织病理学和免疫学检测,同时进行抗药抗体(ADA)及血药浓度检测,并分析毒代动力学参数。结果实验期间2B112个剂量组恒河猴一般症状、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、脏器系数、组织病理学和免疫学检测等指标均未见与受试物有关的明显改变。2B112个剂量组均未检测到ADA,血浆药物浓度变化基本一致,且与给药剂量呈正比,峰浓度之比和暴露量之比也与给药剂量呈正比,2B11注射液在体内基本呈线性动力学特征。结论在本实验条件下,恒河猴2周重复iv给予2B113次是安全的,400 mg·kg^(-1)未观察到临床不良反应。
基金supported by National Natural Science Foundation of China (No. 62071488 and No. 62061013)
文摘In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent jamming problem in a multi-user scenario, where the coordination between the jammers is considered. Firstly, a multi-agent Markov decision process (MDP) framework is used to model and analyze the multi-agent jamming problem. Secondly, a collaborative multi-agent jamming algorithm (CMJA) based on reinforcement learning is proposed. Finally, an actual intelligent jamming system is designed and built based on software-defined radio (SDR) platform for simulation and platform verification. The simulation and platform verification results show that the proposed CMJA algorithm outperforms the independent Q-learning method and provides a better jamming effect.
文摘Xibe Language exhibits a considerable amount of phonetic variation and complexity.Although the phonetic changes in Xibe Language do not serve a distinguishing purpose in the flow of speech,they reflect the phonetic characteristics of the language,thus affecting people's normal communication to a certain extent.Based on field survey data collected in the Xibe people who lives in Qabqaal Xibe Autonomous County,Xinjiang,the author analyzes the phonetic changes and summarizes the patterns of phonetic variation of Xibe Languag.
基金supported by the National Natural Science Foundation of China (Grant Nos. 91858212, 91858214, and 41906056)。
文摘The Neogene is an important period for studying the onset of subduction,with numerous subduction zones forming in the western Pacific,including the Ryukyu,Manila,Philippine,North Sulawesi,Halmahera,New Britain,Solomon,and New Hebrides subduction zones.However,studies on these subduction zones are relatively independent,so it is important to conduct systematic comparative studies.In this paper,we review the initiation models of Neogene subduction in the western Pacific,with the three typical types of subduction initiation models including polarity-reversal,induced subduction re-initiation,and noninherited subduction initiation to form new ruptures.In addition,the parameters of different subduction zones are collated to form five categories:basic features,subducting plate features,upper plate features,kinematic features,and subsequent activity.The regularity of the subduction processes,the specificity of the different subduction cases,and the possible constraints between the subduction initiation types and the characteristics of the subduction zone parameters are discussed and analyzed.The compiled dataset of the subduction zone parameters can provide data support for related studies.
