Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diket...Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.展开更多
Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR ...Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.展开更多
75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.T...75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.展开更多
基金supported by the Doctoral Program Foundation of Institutions of Higher Education of China(No. 20100162110057)National Natural Science Foundation(No. 30873149)+3 种基金Chinese Medicine Research Program of Hunan Province(Nos.2009059 and 2010004)National Innovation Experiment Program for University Students(No.LA10031)Fundamental Research Funds for the Central South Universities of Central South University(No.2012zzts115)Independent Exploration Program of Central South University(No. 201011200235)
文摘Received 9 November 2012 Received in revised form 17 December 2012 Accepted 5 January 2013 Available online 4 February 2013
基金supported by National Natural Science Foundation (No. 31370370)the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057)Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004)
文摘Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
基金supported by grants from the National Natural Science Foundation of China(No.31370370)Key Project of Science and Technology of Hunan Province,China(Nos.2014SK2002 and 2013SK5077)+1 种基金Key Project of Application Technology Research and Development of Haikou(No.2015-039)Social Development and Technology Specific Program of Hainan Province(No.SF201419)
文摘Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.
基金financially supported by the National Natural Science Foundation of China(No.31370370)Key Project of Application Technology Research and Development of Haikou(No.2015-039)+1 种基金Project of Strategic Emerging Industry Technology Research and Major Scientific and Technological Achievements of Hunan(No.2015GK1053)Innovation Project for Graduate Students of Hunan(No.CX2013B100)
文摘75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.
