Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-...Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-old woman with stage I B2 cervical cancer underwent radical hysterectomy and pelvic external beam radiation therapy.Seventeen months later,violaceous lesions began to appear,quickly covering her entire lower abdominal wall,perineum,and upper thighs.These lesions were accompanied by small nodules and ulceration.Immunohistochemistry revealed positive expression of CD31 and CD34.Genetic testing revealed MYC amplification.The patient was finally diagnosed with RAAS and treated with albumin-bound paclitaxel and bevacizumab.However,her condition deteriorated quickly and she died 7 months later.Conclusion This case illustrates the importance of extensive biopsy of skin lesions suspected of denoting RAAS as early as possible.Pathological examination for CD31,CD34,and MYC assists early establishment of the diagnosis.展开更多
Radiotherapy(RT)is an indispensable treatment for nearly all cancer types.Rapid evolution of technology has progressively increased the safely deliverable radiation dose,minimizing the exposure of uninvolved normal ti...Radiotherapy(RT)is an indispensable treatment for nearly all cancer types.Rapid evolution of technology has progressively increased the safely deliverable radiation dose,minimizing the exposure of uninvolved normal tissue and thus improving the efficacy,safety,and accessibility of radiation therapy.Meanwhile,multidisciplinary team management that aims to define personalized,optimal treatment strategies through shared decision-making between healthcare professionals and patients is a fundamental aspect of high-quality cancer diagnosis and treatment and often includes radiation oncology.How to combine this with other anti-tumor modalities,especially immunotherapy,in the era of modern RT has been increasingly emphasized.Here,in this review,we introduce the innovations in RT technology,and aim to provide an outline of the role of contemporary RT in the multidisciplinary treatment of most common cancers,including non-small cell lung cancer,esophageal cancer,breast cancer,hepatocellular carcinoma,gastric/esophageal-gastric junction cancer,and colorectal cancer,focusing on the main areas of innovation that are conducive to a change toward the personalized application of RT.We also discuss the future research directions for combination with modern RT.展开更多
文摘Objective Radiation-associated angiosarcoma(RAAS)is rare.We present an unusual case of RAAS presenting only 1.5 years after radiotherapy for cervical cancer and review relevant published reports.Case report A 59-year-old woman with stage I B2 cervical cancer underwent radical hysterectomy and pelvic external beam radiation therapy.Seventeen months later,violaceous lesions began to appear,quickly covering her entire lower abdominal wall,perineum,and upper thighs.These lesions were accompanied by small nodules and ulceration.Immunohistochemistry revealed positive expression of CD31 and CD34.Genetic testing revealed MYC amplification.The patient was finally diagnosed with RAAS and treated with albumin-bound paclitaxel and bevacizumab.However,her condition deteriorated quickly and she died 7 months later.Conclusion This case illustrates the importance of extensive biopsy of skin lesions suspected of denoting RAAS as early as possible.Pathological examination for CD31,CD34,and MYC assists early establishment of the diagnosis.
基金supported by the National Nature Science Foundation of China(82073479)the Scientific Research Project of Shanghai Science and Technology Commission(20ZR1410600).
文摘Radiotherapy(RT)is an indispensable treatment for nearly all cancer types.Rapid evolution of technology has progressively increased the safely deliverable radiation dose,minimizing the exposure of uninvolved normal tissue and thus improving the efficacy,safety,and accessibility of radiation therapy.Meanwhile,multidisciplinary team management that aims to define personalized,optimal treatment strategies through shared decision-making between healthcare professionals and patients is a fundamental aspect of high-quality cancer diagnosis and treatment and often includes radiation oncology.How to combine this with other anti-tumor modalities,especially immunotherapy,in the era of modern RT has been increasingly emphasized.Here,in this review,we introduce the innovations in RT technology,and aim to provide an outline of the role of contemporary RT in the multidisciplinary treatment of most common cancers,including non-small cell lung cancer,esophageal cancer,breast cancer,hepatocellular carcinoma,gastric/esophageal-gastric junction cancer,and colorectal cancer,focusing on the main areas of innovation that are conducive to a change toward the personalized application of RT.We also discuss the future research directions for combination with modern RT.
