Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury

Rutaecarpine, an active component of the traditional Chinese medicine Tetradium ruticarpum, has been shown to improve myocardial ischemia repeffusion injury. Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease, they are closely related. We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury. A cerebral ischemia reperfusion model was established after 84, 252 and 504 pg/kg rutae- carpine were given to mice via intrapedtoneal injection, daily for 7 days. Results of the step through test, 2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutae- carpine could improve learning and memory ability, neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury. Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain. Therefore, rutaecarpine could improve neu- rological function following injury induced by cerebral ischemia reperfusion, and the mechanism of this improvement may be associated with oxidative stress. These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice.

Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice

Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol（0.1, 1.0, 10.0 mg/kg） was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.

Vitapex糊剂治疗乳与氧化锌根管糊剂治疗儿童乳牙窦道型慢性根尖周炎的效果比较

目的浅析儿童乳牙窦道型慢性根尖周炎(Diseases of periapical tissue,DPT)应用Vitapex糊剂治疗乳和氧化锌根管糊剂治疗的效果比较。方法随机数字表法选取收治的儿童乳牙窦道型DPT患者130例,分为A组与B组各65例,A组实施Vitapex糊剂治疗乳治疗,B组实施氧化锌根管糊剂进行治疗。比较两组术后一周无急性反应率疗效评估以及术后半年进行复查成功率。结果无急性反应率A组(93.85%),B组(90.77%),两组总有疗效比较差异无统计学意义(P>0.05)。成功率A组(95.38%),B组(92.31%),两组疗效评定比较差异无统计学意义(P>0.05)。结论儿童乳牙窦道型慢性DPT运用Vitapex糊剂治疗乳与氧化锌根管糊剂治疗的效果相似,根充后患儿反应皆较轻,家长可根据需求进行手术方法选择。