Genetic mutations in TP53 contribute to human malignancies through various means.To date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p...Genetic mutations in TP53 contribute to human malignancies through various means.To date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other approaches.This review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of cancer.Recombinant human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene therapy.We herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical trials.Notably,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy alone.Finally,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.展开更多
Color pencil drawing is well-loved due to its rich expressiveness.This paper proposes an approach for generating feature-preserving color pencil drawings from photographs.To mimic the tonal style of color pencil drawi...Color pencil drawing is well-loved due to its rich expressiveness.This paper proposes an approach for generating feature-preserving color pencil drawings from photographs.To mimic the tonal style of color pencil drawings,which are much lighter and have relatively lower saturation than photographs,we devise a lightness enhancement mapping and a saturation reduction mapping.The lightness mapping is a monotonically decreasing derivative function,which not only increases lightness but also preserves input photograph features.Color saturation is usually related to lightness,so we suppress the saturation dependent on lightness to yield a harmonious tone.Finally,two extremum operators are provided to generate a foreground-aware outline map in which the colors of the generated contours and the foreground object are consistent.Comprehensive experiments show that color pencil drawings generated by our method surpass existing methods in tone capture and feature preservation.展开更多
基金supported by the National Natural Science Foundation of China(No.82104289)the Yuandu Scholar Grant of Weifang City(Shandong,China)to JJLthe Shandong Provincial Health Commission of China(No.M2022053),。
文摘Genetic mutations in TP53 contribute to human malignancies through various means.To date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other approaches.This review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of cancer.Recombinant human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene therapy.We herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical trials.Notably,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy alone.Finally,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.
基金This work was supported in parts by GD Natural Science Foundation(2021A1515012301,2022A1515011425)the Key Research and Development Project of Guangzhou(202206010091,SL2022B03J01235).
文摘Color pencil drawing is well-loved due to its rich expressiveness.This paper proposes an approach for generating feature-preserving color pencil drawings from photographs.To mimic the tonal style of color pencil drawings,which are much lighter and have relatively lower saturation than photographs,we devise a lightness enhancement mapping and a saturation reduction mapping.The lightness mapping is a monotonically decreasing derivative function,which not only increases lightness but also preserves input photograph features.Color saturation is usually related to lightness,so we suppress the saturation dependent on lightness to yield a harmonious tone.Finally,two extremum operators are provided to generate a foreground-aware outline map in which the colors of the generated contours and the foreground object are consistent.Comprehensive experiments show that color pencil drawings generated by our method surpass existing methods in tone capture and feature preservation.
