According to current guidelines,patients with chronic hepatitis B virus(HBV)infection whose HBVDNA is positive but whose alanine aminotransferase(ALT)levels are normal do not currently need antiviral treatment, Howeve...According to current guidelines,patients with chronic hepatitis B virus(HBV)infection whose HBVDNA is positive but whose alanine aminotransferase(ALT)levels are normal do not currently need antiviral treatment, However,studies have found that even chronic HBV infection'patients withnormal ALTmay,progress to cirrhosis or hepatocellular carcinoma(HCC).Furthermore,almost half of patients with normal ALT levels were found to have moderate to severe inflammation and/or significant fibrosis[2]Currently there were only a few studies on the treatment of chronic HBV patients with normal ALT levels,and the factors that affect their virological response(VR)are still unclear.An increasing number of studies have proven that serum HBV RNAcan be used as a non-invasive indicator to predict a VR,i3i In this study,weexplored the predictivevalue of HBV RNA in anticipating a VR in normal ALTchronic HBV patients.展开更多
基金China Mega-Project for Infectious Diseases(Nos.2013ZX10002005 and 2017ZX10203202)。
文摘According to current guidelines,patients with chronic hepatitis B virus(HBV)infection whose HBVDNA is positive but whose alanine aminotransferase(ALT)levels are normal do not currently need antiviral treatment, However,studies have found that even chronic HBV infection'patients withnormal ALTmay,progress to cirrhosis or hepatocellular carcinoma(HCC).Furthermore,almost half of patients with normal ALT levels were found to have moderate to severe inflammation and/or significant fibrosis[2]Currently there were only a few studies on the treatment of chronic HBV patients with normal ALT levels,and the factors that affect their virological response(VR)are still unclear.An increasing number of studies have proven that serum HBV RNAcan be used as a non-invasive indicator to predict a VR,i3i In this study,weexplored the predictivevalue of HBV RNA in anticipating a VR in normal ALTchronic HBV patients.
