Bacterial outer membrane vesicles(OMVs)are diminutive vesicles naturally released by Gram-negative bacteria.These vesicles possess distinctive characteristics that attract attention for their potential use in drug adm...Bacterial outer membrane vesicles(OMVs)are diminutive vesicles naturally released by Gram-negative bacteria.These vesicles possess distinctive characteristics that attract attention for their potential use in drug administration and immunotherapy in cancer treatment.Therapeutic medicines may be delivered via OMVs directly to the tumor sites,thereby minimizing exposure to healthy cells and lowering the risk of systemic toxicity.Furthermore,the activation of the immune system by OMVs has been demonstrated to facilitate the recognition and elimination of cancer cells,which makes them a desirable tool for immunotherapy.They can also be genetically modified to carry specific antigens,immunomodulatory compounds,and small interfering RNAs,enhancing the immune response to cancerous cells and silencing genes associated with disease progression.Combining OMVs with other cancer treatments like chemotherapy and radiation has shown promising synergistic effects.This review highlights the crucial role of bacterial OMVs in cancer,emphasizing their potential as vectors for novel cancer targeted therapies.As researchers delve deeper into the complexities of these vesicles and their interactions with tumors,there is a growing sense of optimism that this avenue of study will bring positive outcomes and renewed hope to cancer patients in the foreseeable future.展开更多
To the Editor:The amide proton transfer(APT)magnetic resonance imaging(MRI)is an emerging molecular imaging method for detecting mobile proteins/peptides and the potential of hydrogen(pH)with enhanced detection sensit...To the Editor:The amide proton transfer(APT)magnetic resonance imaging(MRI)is an emerging molecular imaging method for detecting mobile proteins/peptides and the potential of hydrogen(pH)with enhanced detection sensitivity compared to direct measurement without external magnetic resonance contrast agents[Figure 1].Such changes may be potential markers for tumor aggressiveness,treatment efficacy,and overall prognosis.Consequently,the utilization of APT can assist medical professionals in devising treatment regimens tailored to the individual needs of cancer patients,resulting in improved therapeutic outcomes.展开更多
Cytocompatibility of high nitrogen nickel-free stainless steel （HNS） with different nitrogen content was evalu- ated and compared with a conventional austenitic stainless steel 317L. The MTT assay （3-（4,5-dimethyl...Cytocompatibility of high nitrogen nickel-free stainless steel （HNS） with different nitrogen content was evalu- ated and compared with a conventional austenitic stainless steel 317L. The MTT assay （3-（4,5-dimethylthiazol- 2-yl）-2,5-diphenyltetrazolium bromide） was performed on MG63 osteoblasts to assess the cytotoxicity. The expression of selected marker typical of differentiated osteoblasts, such as alkaline phosphatase activity （AKP）, was also monitored in MG63 cells cultured on the tested materials. As a result, HNS had higher cell growth than 317L; meanwhile the cytocompatibility was increased with increasing nitrogen content. Furthermore, HNS enhanced osteoblasts differentiation, as confirmed by AKP activity. Overall these facts indicated that HNS had higher cytocompatibility than 317L and the nitrogen content contributed to the higher cytocompatibility of HNS. The influence of nitrogen on surface energy further explained the cytocompatibility of HNS.展开更多
To the Editor:Anthracycline antibiotics are the core treatment strategy forbreast cancer,hematological malignancies,and sarcomas.The main clinical drugs are daunorubicin and doxorubicin.
基金supported by the Fundamental Research Funds for the Central UniversitiesNatural Science Foundation(Nos.2022-YGJC-86 and 2020-ZLLH-38 to Yiming Meng)of Liaoning ProvinceExcellent Talent Fund of Liaoning Province Cancer Hospital of Yiming Meng.
文摘Bacterial outer membrane vesicles(OMVs)are diminutive vesicles naturally released by Gram-negative bacteria.These vesicles possess distinctive characteristics that attract attention for their potential use in drug administration and immunotherapy in cancer treatment.Therapeutic medicines may be delivered via OMVs directly to the tumor sites,thereby minimizing exposure to healthy cells and lowering the risk of systemic toxicity.Furthermore,the activation of the immune system by OMVs has been demonstrated to facilitate the recognition and elimination of cancer cells,which makes them a desirable tool for immunotherapy.They can also be genetically modified to carry specific antigens,immunomodulatory compounds,and small interfering RNAs,enhancing the immune response to cancerous cells and silencing genes associated with disease progression.Combining OMVs with other cancer treatments like chemotherapy and radiation has shown promising synergistic effects.This review highlights the crucial role of bacterial OMVs in cancer,emphasizing their potential as vectors for novel cancer targeted therapies.As researchers delve deeper into the complexities of these vesicles and their interactions with tumors,there is a growing sense of optimism that this avenue of study will bring positive outcomes and renewed hope to cancer patients in the foreseeable future.
基金supported by grants from the Fundamental Research Funds for the Central Universities,Natural Science Foundation of Liaoning Province(Nos.2022-YGJC-86 and 2020-ZLLH-38)Young and Middle-aged Technological Innovation Talents in Shenyang(No.RC200491)Excellent Talent Fund of Liaoning Province Cancer Hospital.
文摘To the Editor:The amide proton transfer(APT)magnetic resonance imaging(MRI)is an emerging molecular imaging method for detecting mobile proteins/peptides and the potential of hydrogen(pH)with enhanced detection sensitivity compared to direct measurement without external magnetic resonance contrast agents[Figure 1].Such changes may be potential markers for tumor aggressiveness,treatment efficacy,and overall prognosis.Consequently,the utilization of APT can assist medical professionals in devising treatment regimens tailored to the individual needs of cancer patients,resulting in improved therapeutic outcomes.
基金supported by the National Natural Science Foundation of China (No. 31000428)the National Basic Research Program of China ("973 Program",No. 2012CB619101)
文摘Cytocompatibility of high nitrogen nickel-free stainless steel （HNS） with different nitrogen content was evalu- ated and compared with a conventional austenitic stainless steel 317L. The MTT assay （3-（4,5-dimethylthiazol- 2-yl）-2,5-diphenyltetrazolium bromide） was performed on MG63 osteoblasts to assess the cytotoxicity. The expression of selected marker typical of differentiated osteoblasts, such as alkaline phosphatase activity （AKP）, was also monitored in MG63 cells cultured on the tested materials. As a result, HNS had higher cell growth than 317L; meanwhile the cytocompatibility was increased with increasing nitrogen content. Furthermore, HNS enhanced osteoblasts differentiation, as confirmed by AKP activity. Overall these facts indicated that HNS had higher cytocompatibility than 317L and the nitrogen content contributed to the higher cytocompatibility of HNS. The influence of nitrogen on surface energy further explained the cytocompatibility of HNS.
基金This study received basic scientific research business fees from central universities and was supported by Natural Science Foundation(Nos.20180550488 and 2020-ZLLH-38)of Liaoning ProvinceYoung and Middle-aged Technological Innovation Talents in Shenyang(No.RC200491)Excellent Talent Fund of Liaoning Province Cancer Hospital.
文摘To the Editor:Anthracycline antibiotics are the core treatment strategy forbreast cancer,hematological malignancies,and sarcomas.The main clinical drugs are daunorubicin and doxorubicin.
