Objective:The current meta-analysis determined the relevance of HLA-DRB1 gene polymor-phisms in a Chinese population with pulmonary tuberculosis.Methods:The CBM,CNKI,and MEDLINE databases were retrieved by computers.D...Objective:The current meta-analysis determined the relevance of HLA-DRB1 gene polymor-phisms in a Chinese population with pulmonary tuberculosis.Methods:The CBM,CNKI,and MEDLINE databases were retrieved by computers.Domes-tic and international documents involving studies on the relevance of HLA-DRB1 gene polymor-phisms in a Chinese population with pulmonary tuberculosis were collected from the database until May 2013,and statistical analysis was performed on all of the eligible results with RevMan5.0 software.Results:Eleven case-control studies were collected,including 1364 cases in the pulmonary tuberculosis group and 1496 cases in the control group.The consolidated OR values and 95%confidence intervals of the case and control groups of HLA-DRB1*04,HLA-DRB1*15,and HLA-DRB1*16 were 1.32(1.09-1.60),1.40(1.01-1.93),and 1.36(1.01-1.83),respectively.Conclusion:HLA-DRB1*04,HLA-DRB1*15,and HLA-DRB1*16 may be susceptibility genes for pulmonary tuberculosis in a Chinese population.展开更多
文摘Objective:The current meta-analysis determined the relevance of HLA-DRB1 gene polymor-phisms in a Chinese population with pulmonary tuberculosis.Methods:The CBM,CNKI,and MEDLINE databases were retrieved by computers.Domes-tic and international documents involving studies on the relevance of HLA-DRB1 gene polymor-phisms in a Chinese population with pulmonary tuberculosis were collected from the database until May 2013,and statistical analysis was performed on all of the eligible results with RevMan5.0 software.Results:Eleven case-control studies were collected,including 1364 cases in the pulmonary tuberculosis group and 1496 cases in the control group.The consolidated OR values and 95%confidence intervals of the case and control groups of HLA-DRB1*04,HLA-DRB1*15,and HLA-DRB1*16 were 1.32(1.09-1.60),1.40(1.01-1.93),and 1.36(1.01-1.83),respectively.Conclusion:HLA-DRB1*04,HLA-DRB1*15,and HLA-DRB1*16 may be susceptibility genes for pulmonary tuberculosis in a Chinese population.
