Ultra-Low-Dose Pre-Metallation Strategy Served for Commercial Metal-Ion Capacitors

Sacrificial pre-metallation strategy could compensate for the irreversible consumption of metal ions and reduce the potential of anode,thereby elevating the cycle performance as well as open-circuit voltage for full metal ion capacitors(MICs).However,suffered from massive-dosage abuse,exorbitant decomposition potential,and side effects of decomposition residue,the wide application of sacrificial approach was restricted.Herein,assisted with density functional theory calculations,strongly coupled interface(M-O-C,M=Li/Na/K)and electron donating group have been put forward to regulate the band gap and highest occupied molecular orbital level of metal oxalate(M_(2)C_(2)O_(4)),reducing polarization phenomenon and Gibbs free energy required for decomposition,which eventually decrease the practical decomposition potential from 4.50 to 3.95 V.Remarkably,full sodium ion capacitors constituted of commercial materials(activated carbon//hard carbon)could deliver a prominent energy density of 118.2 Wh kg^(−1)as well as excellent cycle stability under an ultra-low dosage pre-sodiation reagent of 15-30 wt%(far less than currently 100 wt%).Noteworthily,decomposition mechanism of sacrificial compound and the relative influence on the system of MICs after pre-metallation were initially revealed by in situ differential electrochemical mass spectrometry,offering in-depth insights for comprehending the function of cathode additives.In addition,this breakthrough has been successfully utilized in high performance lithium/potassium ion capacitors with Li_(2)C_(2)O_(4)/K_(2)C_(2)O_(4) as pre-metallation reagent,which will convincingly promote the commercialization of MICs.

A systematic review of phytochemicals from Chinese herbal medicines for non-coding RNAs-mediated cancer prevention and treatment:From molecular mechanisms to potential clinical applications

Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find alternative therapies with effective cancer prevention and treatment.Chinese herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged properties.CHMs are useful in the suppression of various types of cancers through different mechanisms of action.Non-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and development.Regulation of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and treatment.Substantial evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling pathways.Herein,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular mechanisms.This review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.