Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedic...Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dualfunctional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradiation of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated processes and toxic organic solvents.Moreover,because all the components were biocompatible,the resulting membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.21774086 and 22175125)the Natural Science Foundation of Jiangsu Province(No.BK20180093)+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.21KJA150008)the Suzhou Municipal Science and Technology Foundation(No.SYS2018026)。
文摘Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dualfunctional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradiation of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated processes and toxic organic solvents.Moreover,because all the components were biocompatible,the resulting membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.
