We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients ...We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients with mild to moderate AD diagnosed according to NINCDS- ADRDA criteria and 10 age- matched control subjects were included in this prospective study. All subjects underwent ERP rec ordings and Tc- 99m HMPAO brain SPECT study. Cortical perfusion index (CPI)- w as calculated as the ratio of cortical activity to the cerebellum activity. CPI was found to be statistically lower in bilaterally posterolateral temporal corte x and precuneus in the moderate AD compared to the control group. There was no s tatistically significant difference between the mild AD and control groups for C PI in any cortical areas. The mean P300 latency was statistically prolonged in t he mild and moderate AD compared to the control group. In addition, in moderate AD P300 latency was longer than in mild AD. While the mean P300 amplitude was st atistically reduced in moderate AD compared to the control and mild AD, there wa s no statistically significant difference between the mild AD and control groups . There was a strong negative correlation between P300 latency and CPI in the ri ght and left precuneus in the moderate AD group. The present study suggested tha t Tc- 99m HMPAO SPECT study is the more appropriate technique for patients with moderate AD rather than mild AD. Our results indicated that alterations in ERPs , especially prolongation of P300 latency could be a finding that occurred earli er than the deterioration in cerebral blood flow. We thought that precuneus is c losely related to cognitive function and may have an important role in the patho physiology of AD.展开更多
文摘We investigated whether brain SPECT findings show any differences between pat ients with mild and moderate Alzheimer’ s disease (AD) and to compare results w ith event related potentials (ERPs). Twenty- two patients with mild to moderate AD diagnosed according to NINCDS- ADRDA criteria and 10 age- matched control subjects were included in this prospective study. All subjects underwent ERP rec ordings and Tc- 99m HMPAO brain SPECT study. Cortical perfusion index (CPI)- w as calculated as the ratio of cortical activity to the cerebellum activity. CPI was found to be statistically lower in bilaterally posterolateral temporal corte x and precuneus in the moderate AD compared to the control group. There was no s tatistically significant difference between the mild AD and control groups for C PI in any cortical areas. The mean P300 latency was statistically prolonged in t he mild and moderate AD compared to the control group. In addition, in moderate AD P300 latency was longer than in mild AD. While the mean P300 amplitude was st atistically reduced in moderate AD compared to the control and mild AD, there wa s no statistically significant difference between the mild AD and control groups . There was a strong negative correlation between P300 latency and CPI in the ri ght and left precuneus in the moderate AD group. The present study suggested tha t Tc- 99m HMPAO SPECT study is the more appropriate technique for patients with moderate AD rather than mild AD. Our results indicated that alterations in ERPs , especially prolongation of P300 latency could be a finding that occurred earli er than the deterioration in cerebral blood flow. We thought that precuneus is c losely related to cognitive function and may have an important role in the patho physiology of AD.
