目的:探讨高血压伴原因未明低钾血症患者在低钾状态下高血压过程中炎症因子的变化情况。方法:依据纳排标准,选取242例高血压伴原因未明低钾血症患者(观察组)及257例原发性高血压合并血钾正常(4.0~4.5 mmol/L)的患者(对照组)。对比分析...目的:探讨高血压伴原因未明低钾血症患者在低钾状态下高血压过程中炎症因子的变化情况。方法:依据纳排标准,选取242例高血压伴原因未明低钾血症患者(观察组)及257例原发性高血压合并血钾正常(4.0~4.5 mmol/L)的患者(对照组)。对比分析两组患者临床资料及靶器官损害情况,应用ELISA法检测并对比两组患者(各16例)血清炎症因子(促炎因子:IL-1β、TNF-α、IL-6、IL-8;抗炎因子:TGF-β1、IL-10)的表达情况。结果:与对照组相比,观察组患者年龄更低[(50.01±13.92)岁vs(46.34±12.22)岁,P=0.002],BMI更高[(22.99±2.71)kg/m^(2)vs(26.16±3.32)kg/m^(2),P<0.001],尿微量白蛋白更高[3.01(0,10.80)mg/L vs 8.8(1.24,28.42)mg/L,P<0.001],外周动脉及靶器官损害更重(P<0.05);低钾状态下,外周血中炎症因子如IL-1β、IL-6、IL-8、TGF-β1、TNF-α表达增加(P<0.05),IL-10表达低于对照组(P<0.001)。结论:低钾状态可能诱导机体炎症因子分泌增加,炎症反应更明显,促进高血压伴原因未明低钾血症患者外周动脉硬化及靶器官损害的发生。展开更多
The rotating packed bed(RPB), mainly including the countercurrent-flow RPB(Counter-RPB) and the crosscurrentflow RPB(Cross-RPB) that are classified from the perspective of gas-liquid contact style, is a novel process ...The rotating packed bed(RPB), mainly including the countercurrent-flow RPB(Counter-RPB) and the crosscurrentflow RPB(Cross-RPB) that are classified from the perspective of gas-liquid contact style, is a novel process intensification device. A significant measurement standard for evaluating the performance of RPB is the mass transfer effect. In order to compare the mass transfer characteristics of Counter-RPB and Cross-RPB with the same size, the liquid volumetric mass transfer coefficient(k_La_e) and effective interfacial area(a_e) were measured under identical operating conditions. Meanwhile, the comparison of comprehensive mass transfer performance was conducted using the ratio of ΔP(pressure drop) to kLae as the standard. Experimental results indicated that kLae and ae increased with the increase in liquid spray density q, gas velocity u, and high gravity factor β. Furthermore, compared with the Cross-RPB, the Counter-RPB has higher liquid volumetric mass transfer coefficient and slightly larger effective interfacial area. The experimental results of comprehensive mass transfer performance showed that the Counter-RPB had higher ΔP/k_La_e than the Cross-RPB with changes in liquid spray density and high gravity factor, and there exists a turning point at 0.71 m/s accompanied by a variation with gas velocity. Moreover, the relative error of experimental value to calculated value, which was computed by the correlative expressions of kLae, was less than 5 %. In conclusion, the mass transfer characteristics of RPB are deeply impacted by the manner in which the flows are established and the Cross-RPB would have a great potential for industrial scale-up applications.展开更多
文摘目的:探讨高血压伴原因未明低钾血症患者在低钾状态下高血压过程中炎症因子的变化情况。方法:依据纳排标准,选取242例高血压伴原因未明低钾血症患者(观察组)及257例原发性高血压合并血钾正常(4.0~4.5 mmol/L)的患者(对照组)。对比分析两组患者临床资料及靶器官损害情况,应用ELISA法检测并对比两组患者(各16例)血清炎症因子(促炎因子:IL-1β、TNF-α、IL-6、IL-8;抗炎因子:TGF-β1、IL-10)的表达情况。结果:与对照组相比,观察组患者年龄更低[(50.01±13.92)岁vs(46.34±12.22)岁,P=0.002],BMI更高[(22.99±2.71)kg/m^(2)vs(26.16±3.32)kg/m^(2),P<0.001],尿微量白蛋白更高[3.01(0,10.80)mg/L vs 8.8(1.24,28.42)mg/L,P<0.001],外周动脉及靶器官损害更重(P<0.05);低钾状态下,外周血中炎症因子如IL-1β、IL-6、IL-8、TGF-β1、TNF-α表达增加(P<0.05),IL-10表达低于对照组(P<0.001)。结论:低钾状态可能诱导机体炎症因子分泌增加,炎症反应更明显,促进高血压伴原因未明低钾血症患者外周动脉硬化及靶器官损害的发生。
基金supported by the National Key R&D Program of China:The ultra-low emission control technology for coal-fired industrial boilers(2016YFC0204103)the Provincial Key R&D Program of Shanxi:R&D of the coal-fired industrial boiler smoke ultra-low emission technology and equipment(201703D111018)
文摘The rotating packed bed(RPB), mainly including the countercurrent-flow RPB(Counter-RPB) and the crosscurrentflow RPB(Cross-RPB) that are classified from the perspective of gas-liquid contact style, is a novel process intensification device. A significant measurement standard for evaluating the performance of RPB is the mass transfer effect. In order to compare the mass transfer characteristics of Counter-RPB and Cross-RPB with the same size, the liquid volumetric mass transfer coefficient(k_La_e) and effective interfacial area(a_e) were measured under identical operating conditions. Meanwhile, the comparison of comprehensive mass transfer performance was conducted using the ratio of ΔP(pressure drop) to kLae as the standard. Experimental results indicated that kLae and ae increased with the increase in liquid spray density q, gas velocity u, and high gravity factor β. Furthermore, compared with the Cross-RPB, the Counter-RPB has higher liquid volumetric mass transfer coefficient and slightly larger effective interfacial area. The experimental results of comprehensive mass transfer performance showed that the Counter-RPB had higher ΔP/k_La_e than the Cross-RPB with changes in liquid spray density and high gravity factor, and there exists a turning point at 0.71 m/s accompanied by a variation with gas velocity. Moreover, the relative error of experimental value to calculated value, which was computed by the correlative expressions of kLae, was less than 5 %. In conclusion, the mass transfer characteristics of RPB are deeply impacted by the manner in which the flows are established and the Cross-RPB would have a great potential for industrial scale-up applications.
