A class of polynomial primal-dual interior-point algorithms for second-order cone optimization based on a new parametric kernel function, with parameters p and q, is presented. Its growth term is between linear and qu...A class of polynomial primal-dual interior-point algorithms for second-order cone optimization based on a new parametric kernel function, with parameters p and q, is presented. Its growth term is between linear and quadratic. Some new tools for the analysis of the algorithms are proposed. The complexity bounds of O（√Nlog N log N/ε） for large-update methods and O（√Nlog N/ε） for smallupdate methods match the best known complexity bounds obtained for these methods. Numerical tests demonstrate the behavior of the algorithms for different results of the parameters p and q.展开更多
To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h c...To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.展开更多
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fu...To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.展开更多
文摘A class of polynomial primal-dual interior-point algorithms for second-order cone optimization based on a new parametric kernel function, with parameters p and q, is presented. Its growth term is between linear and quadratic. Some new tools for the analysis of the algorithms are proposed. The complexity bounds of O（√Nlog N log N/ε） for large-update methods and O（√Nlog N/ε） for smallupdate methods match the best known complexity bounds obtained for these methods. Numerical tests demonstrate the behavior of the algorithms for different results of the parameters p and q.
基金supported by the National Natural Science Foundation of China(Nos20872028 and 21072045)
文摘To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.
基金supported by National Natural Science Foundation of China(Nos.20872028,21072045)
文摘To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.
