A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical pro...A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.展开更多
基金supported financially by NSFC(Nos.90717120 and 20435030),MOST(No.2007CB714504)Sino German Center for Research Promotion(No.GZ364) and CAS(No.KJCX2-YW-H11).
基金supported by the Major State Basic Research Development Program(Grant No.F2000078100)the National Natural Science Foundation of China(No.20172059)the Found of Chinese Academy of Sciences.
文摘A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.
基金to the Major State Basic Research Development Program,Grant No.F2000078100the National Natural Science Foundation of China(No.20172059)and Chinese Academy of Sciences.
