New matrix, metal-phthalocyanine （MPc）, of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） was used for analysis of small molecules （usually 〈500 Da）. By using MPcs a...New matrix, metal-phthalocyanine （MPc）, of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） was used for analysis of small molecules （usually 〈500 Da）. By using MPcs as matrices, small molecular samples were moved to high mass-to-charge region where there was no interference caused by the traditional matrices. The mass of the target analvte was obtained by simple calculation.展开更多
A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical pro...A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.展开更多
基金supported financially by NSFC(Nos.90717120 and 20435030),MOST(No.2007CB714504)Sino German Center for Research Promotion(No.GZ364) and CAS(No.KJCX2-YW-H11).
文摘New matrix, metal-phthalocyanine （MPc）, of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） was used for analysis of small molecules （usually 〈500 Da）. By using MPcs as matrices, small molecular samples were moved to high mass-to-charge region where there was no interference caused by the traditional matrices. The mass of the target analvte was obtained by simple calculation.
基金supported by the Major State Basic Research Development Program(Grant No.F2000078100)the National Natural Science Foundation of China(No.20172059)the Found of Chinese Academy of Sciences.
文摘A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.
基金to the Major State Basic Research Development Program,Grant No.F2000078100the National Natural Science Foundation of China(No.20172059)and Chinese Academy of Sciences.
