A novel computational system was used to decipher the targets and mechanisms of Chrysanthemum morifolium against hepatocellular carcinoma.The putative target profile of Chrysanthemum morifolium against hepatocellular ...A novel computational system was used to decipher the targets and mechanisms of Chrysanthemum morifolium against hepatocellular carcinoma.The putative target profile of Chrysanthemum morifolium against hepatocellular carcinoma was identified from Traditional Chinese Medicine Systems Pharmacology and DrugBank.Next,identification of the protein-protein interaction network of Chrysanthemum morifolium against hepatocellular carcinoma targets,and the identification of differentially expressed genes in hepatocellular carcinoma,relied on data from the NCBI database.Finally,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to analyze the common targets.Forty-eight active compounds in Chrysanthemum morifolium were identified by Traditional Chinese Medicine Systems Pharmacology and DrugBank,and 71 differentially expressed genes were identified in the GEO database.Further,10 core target proteins were selected,including CYP1A1,ADRB2,ADRA1B,PGR,MAOB,SLC6A4,GABRA1,MAOA,NOS3 and PTGS2.These target genes were also found to be associated with pathways involved in adrenergic receptor activity and catecholamine binding.展开更多
Objective:To systematically evaluate the willingness rate of the community to provide for the aged at home and analyze its influencing factors.Methods:By searching the CNKI,VIP,Wanfang,we collected literature on the w...Objective:To systematically evaluate the willingness rate of the community to provide for the aged at home and analyze its influencing factors.Methods:By searching the CNKI,VIP,Wanfang,we collected literature on the willingness of the elderly in the community to provide for the aged from 2011 to 2021,extracted the data,and evaluated the quality of the included literature.Then,CMA 2.0 software was used for Meta-analysis.Results:A total of 13 articles were included in this study,and 16,402 people over 60 years old were surveyed,1782 people were willing to provide for the aged at home in the community,with a total willingness rate of 11%(95%CI:9%to 26%).The results of subgroup analysis showed that there was a statistically significant difference in the community home care willingness rate of elderly people with different gender,education levels,marital status,monthly income,living alone,the number of children,and residence(P<0.05).There was not any statistically significant difference in the willingness rate of the elderly with different ages,chronic diseases,self-care ability,and loneliness(P>0.05).Conclusion:The overall willingness rate of the elderly in the community of the elderly is relatively low in China.Gender,education level,marital status,monthly income,living alone,number of children,and residence are factors affecting the prediction of community elderly will.展开更多
基金This work was supported by Anyang science and Technology development plan project in 2020(Project No.228).
文摘A novel computational system was used to decipher the targets and mechanisms of Chrysanthemum morifolium against hepatocellular carcinoma.The putative target profile of Chrysanthemum morifolium against hepatocellular carcinoma was identified from Traditional Chinese Medicine Systems Pharmacology and DrugBank.Next,identification of the protein-protein interaction network of Chrysanthemum morifolium against hepatocellular carcinoma targets,and the identification of differentially expressed genes in hepatocellular carcinoma,relied on data from the NCBI database.Finally,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to analyze the common targets.Forty-eight active compounds in Chrysanthemum morifolium were identified by Traditional Chinese Medicine Systems Pharmacology and DrugBank,and 71 differentially expressed genes were identified in the GEO database.Further,10 core target proteins were selected,including CYP1A1,ADRB2,ADRA1B,PGR,MAOB,SLC6A4,GABRA1,MAOA,NOS3 and PTGS2.These target genes were also found to be associated with pathways involved in adrenergic receptor activity and catecholamine binding.
基金supported by Project of Henan Federation of Social Sciences in 2021(NO.SKL-2021-415)Anyang science and Technology development plan project in 2020(Project No.228).
文摘Objective:To systematically evaluate the willingness rate of the community to provide for the aged at home and analyze its influencing factors.Methods:By searching the CNKI,VIP,Wanfang,we collected literature on the willingness of the elderly in the community to provide for the aged from 2011 to 2021,extracted the data,and evaluated the quality of the included literature.Then,CMA 2.0 software was used for Meta-analysis.Results:A total of 13 articles were included in this study,and 16,402 people over 60 years old were surveyed,1782 people were willing to provide for the aged at home in the community,with a total willingness rate of 11%(95%CI:9%to 26%).The results of subgroup analysis showed that there was a statistically significant difference in the community home care willingness rate of elderly people with different gender,education levels,marital status,monthly income,living alone,the number of children,and residence(P<0.05).There was not any statistically significant difference in the willingness rate of the elderly with different ages,chronic diseases,self-care ability,and loneliness(P>0.05).Conclusion:The overall willingness rate of the elderly in the community of the elderly is relatively low in China.Gender,education level,marital status,monthly income,living alone,number of children,and residence are factors affecting the prediction of community elderly will.
