超高频剪切波弹性超声成像检测正中神经改变对腕管综合征的诊断价值

目的探讨超高频剪切波弹性超声成像检测正中神经改变对腕管综合征(CTS)的诊断价值。方法选取2017年3月-2019年12月宁波大学医学院附属医院收治的经临床和神经电生理检查诊断为CTS的患者108例作为CTS组,另取同期该院健康体检者30例作为对照组。对两组受试者行超高频剪切波弹性超声成像检查,比较两组受试者各参数的差异,绘制受试者工作特征曲线,分析各参数对CST的诊断效能。结果两组二维超声结果显示,CTS组正中神经DW、CSAW值高于对照组(P<0.05)。超高频剪切波弹性超声成像结果显示,CTS组豌豆骨水平正中神经的弹性模量均值(WEmean)、前臂区距离腕横纹上5cm处正中神经弹性的弹性模量均值(FEmean)及该平面同一目标区域内正中神经与指浅屈肌的弹性模量均值比(FRatio)高于对照组(P<0.05)。ROC曲线结果显示,WEmean、FEmean、FRatio诊断CTS的曲线下面积(AUC)分别为0.830、0.768和0.752,敏感性分别为83.17%(95%CI:0.798,0.907)、79.32%(95%CI:0.712,0.856)、72.38%(95%CI:0.705,0.822),特异性分别为78.33%(95%CI:0.831,0.916)、82.15%(95%CI:0.792,0.879)、67.29%(95%CI:0.710,0.813)。结论超高频剪切波弹性超声成像可准确反映正中神经硬度,从而为CTS临床诊断提供一种无创、简便的方式,具有良好的临床应用价值。

Study on the influence of curcumin on chemosensitivity of nephroblastoma cells

Objective:To study the influence of curcumin on chemosensitivity of nephroblastoma cells.Methods:Human nephroblastoma cells line SK-NEP-1 was transplanted to the nude mice subcutaneously to establish the implantation tumor model of human nephroblastoma cells.A total of 30 tumor-bearing mice were divided into three groups of ten randomly.The routine chemotherapy group was given vincristine(0.05 mg/mL·0.2 mL/d) and actinomycin D(15 ng/mL·0.2 mL/d) combined chemotherapy regime.The curcumin chemotherapy group was given the same combined chemotherapy regimens and curcumin(30 mg/kg/d) by intraperitoneal injection.The control group was given normal saline(NS) of the same volume by intraperitoneal injection.Continuous administration would be kept for 4 weeks and 3 days a week.The volumetric changes of every group were recorded.The serum of every group in different time was collected and the VEGF content was detected by ELISA.All mice were cercrificed and the tumor tissues were stripped and weighed after 4 weeks’ treatment.The tumor inhibition rate was calculated.The cell proliferation activity and apoptosis rate were detected by MTT and flow cytometry method.All data were statistically analyzed by SPSS 19.0.Results:The tumor volume,serum VEGF content,tumor inhibition rate,cell proliferation activity and apoptosis rate of routine chemotherapy group and curcumin chemotherapy group had significant differences comparing with the control group(P<0.05) after 4-week’s treatment.The cancer growth of curcumin chemotherapy group was obviously decreased and even tended to shrink comparing with routine chemotherapy group(χ2=15.732,P=0.007).The cell proliferation activity was significantly reduced and the apoptosis rate was significantly higher,(χ~2=9.427,P=0.012)which showing the effect of chemotherapy was enhanced.Conclusions:The chemosensitivity of nephroblastoma cells could be improved by curcumin,then the effect of preoperative adjuvant chemotherapy scheme would be enhanced,the growth of nephroblastoma cells would be inhibited and the surgical risk of nephroblastoma would be reduced.

PHOTOSWITCHABLE NANOFLUOROPHORES FOR INNOVATIVE BIOIMAGING

Photosensitive fluorescent probes have become powerful tools in chemical biology and molecular biophysics,which are used to investigate cellular processes with high temporal and spatial resolution.Accordingly,photosensitive fluorescent probes,including photoactivatable,photoconvertible,and photoswitchable fluorophores,have been extensively developed during the past decade.The photoswitchable fluorophores have received much attention because they highlight cellular events clearly.This minireview summarizes recent advances of using reversibly photoswitchable fluorophores and their applications in innovative bioimaging.Photoswitchable fluorophores include photoswitchable fluorescent proteins,photoswitchable fluorescent organic molecules(dyes),and photoswitchable fluorescent nanoparticles.Several strategies have been developed to synthesize photoswitchable fluorophores,including engineering combination proteins,chemical synthesis,polymerization,and self-assembly.Here we concentrate on polymer nanoparticles with optically switchable emission properties:either fluorescence on/offor dualalternating-color fluorescence photoswitching.The essential mechanisms of fluorescence photoswitching enable different types of photoswitchable fluorophores to change emission intensity or wavelength(color)and thus validating the basis of the fluorescence on/offor dual-color photoswitching design.Generally the possible applications of any fluorophores are to label biological targets,followed by specific imaging.The newly developed photoswitchable fluorophores enable super-resolution fluorescence imaging because of their photosensitive emission.Finally,we summarize the important area regarding future research and development on photoswitchable fluorescent nanoparticles.

Charging and self-discharging process of a quantum battery in composite environments

How to improve charging processes and suppress self-discharging processes has always been one of the key issues to achieve quantum batteries with high performance.Although a quantum battery is inevitably influenced by composite environments,this situation is still little understood,particularly regarding the influence of the memory effect of the composite environments and the coupling between composite environments.In this work,we investigate the effects of the composite environments,composed of two identical parts each containing a single cavity mode decaying to a reservoir,on the charging and self-discharging processes of a quantum battery.We show that increasing the two-mode coupling can effectively enhance the charging performance(i.e.,the stored energy,the charging power,ergotropy)and restrain the self-discharging process(i.e.,suppressing the process of dissipating the energy).However,different from the effect of two-mode coupling,we reveal that the memory effect of the reservoir in this composite environment is unfavorable to the charging process of the quantum battery,which is in sharp contrast to previous studies where the memory effect can significantly improve the charging performance of a quantum battery.Our results may benefit to the realization of quantum batteries with high performance under the actual complex environmental noise.

Linear dipole behavior of single quantum dots encased in metal oxide semiconductor nanoparticles films

Understanding of charge/energy exchange processes and interfacial interactions that occur between quantum dots (QDs) and the metal oxides is of critical importance to these QD-based optoelectronic devices. This work reports on linear dipole behavior of single near-infrared emitting CdSeTe/ZnS core/shell QDs which are encased in indium tin oxide (ITO) semiconductor lianoparticles films. A strong polarization anisotropy in photohiminescence emission is observed by defocused wide-field imaging and polarization measuremen11echniques, and the average polarization degree is up to 0.45. A possible mechanism for the observation is presented in which the electrons, locating at single QD surface from ITO by electron transfer due to the equilibration of the Fermi levels, result in a significant Stark distortion of the QD electron/hole wavefunctions. The Stark distortion results in the linear polarization property of the single QDs. The investigation of linear dipole behavior for single QDs encased in ITO films would be helpful for further improving QD-based device performance.

Influence of surface charges on the emission polarization properties of single CdSe/CdS dot-in-rods

We report an experimental investigation of the influence of surface charges on the emission polarization properties of single CdSe/CdS dot-in-rods(DRs),which is important for their polarization-based practical applications.By covering the single DRs with N-type semiconductor indium tin oxide(ITO)nanoparticles,the surface of single DRs is charged by ITO through interracial electron transfer.This is confirmed by the experimental observations of the reduced photoluminescence intensities and lifetimes as well as the suppressing blinking.It is found that the full width at half maximum of histogram of polarization degrees of the single DRs is broadened from 0.24(on glass)to 0.41(in ITO).In order to explain the exprimental results,the band-edge exciton fine structure of single DRs is calculated by taking into account the sample parameters,the emission polarization,and the surface charges.The calculation results show that the level ordering of the emitting states determines the polarization degrees tending to increase or decrease under the influence of surface electrons.The surface electrons can induce an increase in the spacing between the emitting levels to change the populations and thus change the polarization degrees.In addition,different numbers of surface electrons may randomly distribute on the long CdSe/CdS rods,leading to the heterogeneous influences on the single DRs causing the broadening of polarization degrees also.

Modification of single molecule fluorescence using external fields

控制并且操作单个 fluorophores 的荧光具有对为它在改进分子的 photonics 和分子的电子学的表演的潜在的使用的最近的年的大兴趣，例如在基于单个分子的器官的轻射出的设备，单个光子来源，器官的地效果晶体管，和探针或传感器。这评论显示出单个器官的分子的荧光排放怎么能用金属性的 nanostructures 和 electric-field-induced 电子转移的本地电磁的领域被修改。荧光开关的 Electric-field-induced 荧光调整，磁滞现象，和成就详细被讨论。

Giant enhancement of photoluminescence emission in monolayer WS_(2)by femtosecond laser irradiation

Monolayer transition metal dichalcogenides have emerged as promising mat erials for opt oelectTonic and nanophotonic devices.However,the low photoluminescence(PL)quantum yield(QY)hinders their various potential applications.Here we engineer and enhance the PL intensity of monolayer WS_(2)by femtosecond laser irradiation.More than two orders of magnitude enhancement of PL intensity as compared to the as-prepared sample is determined.Furthermore,the engineering time is shortened by three orders of magnitude as compared to the improvement of PL intensity by continuous-wave laser irradiation.Based on the evolution of PL spectra,we attribute the giant PL enhancement to the conversion from trion emission to exciton,as well as the improvement of the QY when exciton and trion are localized to the new-formed defects.We have created microstructures on the monolayer WS_(2)based on the enhancement of PL intensity,where the engineered structures can be stably stored for more than three years.This flexible approach with the feature of excellent long-term storage stability is promising for applications in information storage,display technology,and opto electronic devices.

Synthesis of Fluorene-Bridged Arylene Vinylene Fluorophores： Effects of End-Capping Groups on the Optical Properties, Aggregation Induced Emission

We have synthesized a series of fluorene-based fluorophores, in which a central fluorene core has been modified with different peripheral arylene vinylene substituents that are able to activate aggregation-induced emission （AIE） characteristics. 9,9-Dioctylfluorene doubly end-capped at the 2,7-positions with triphenylethene groups, such as 4-（2,2-diphenylvinyl）phenyl （F1-（2,2）-HTPE） and 4-（1,2-dipbenylvinyl）phenyl （F1-（1,2）-HTPE） were synthesized and compared to the tetraphenylethene analogue （F1-TPE）. Both FI-（2,2）-HTPE and F1-（1,2）-HTPE glow with a deep blue fluorescence in THF solution with emission maxima （λem） of 426 and 403 nm, respectively. The λem slightly red-shifts in the solid-state to 458 nm for F 1-（2,2）-HTPE and 437 nm for F 1-（1,2）-HTPE. The fluorescence quantum yields （ΦF） of F1-（2,2）-HTPE （ΦF=35.1%） and FI-（1,2）-HTPE （ΦF=26.2%） were found to be higher in solution compared to the near quenching of F 1-TPE （ΦF = 0.1%）. Consequently, this results in weaker AIE-stability of F1-（2,2）-HTPE （αAIE= 1.5） and F1-（1,2）-HTPE （αAIE=1.9） compared to F1-TPE （αAIE=125）, suggesting that four phenyl groups are necessary for efficient AIE-activity of these fluorene bridged arylene vinylene type materials In addition, decreasing the steric hindrance around the arylene vinylene moiety by removal of a phenyl ring is an- other method to decrease the AIE characteristics, in a similar manner to the commonly known ＂phenyl-locking＂. Non-polar triphenylethenes are poorer AlE materials than their tetraphenylethene analogues. Replacing the hydro- gen atom of F1-（2,2）-HTPE with a cyano group affords fluorene end-capped with 2,3,3-triphenylacrylonitrile （F1-TPAN）, which boosts the AIE-effect to αAIE=90.5 and red-shifts the solid-state emission （λem=528 nm） with near quenching in THF solution （ΦF= 0.12%）. X-ray crystallographic analysis of F1-TPAN indicates that the intro- duction of cyano groups can not only diminish the intramolecular steric hindrance in comparison of F1-TPE, but also improve the molecular cohesion ability via multiple C--H...N interactions.

May 2022 Greedy Kaczmarz Algorithm Using Optimal Intermediate Projection Technique for Coherent Linear Systems

The Kaczmarz algorithm is a common iterative method for solving linear systems.As an effective variant of Kaczmarz algorithm,the greedy Kaczmarz algorithm utilizes the greedy selection strategy.The two-subspace projection method performs an optimal intermediate projection in each iteration.In this paper,we introduce a new greedy Kaczmarz method,which give full play to the advantages of the two improved Kaczmarz algorithms,so that the generated iterative sequence can exponentially converge to the optimal solution.The theoretical analysis reveals that our algorithm has a smaller convergence factor than the greedy Kaczmarz method.Experimental results confirm that our new algorithm is more effective than the greedy Kaczmarz method for coherent systems and the two-subspace projection method for appropriate scale systems.