AIM: To investigate the expression of interferon inducible protein-10 (IP-10) in pancreas of mice and to discuss its possible role in the pathogenesis of type 1 diabetes.METHODS: Non-obese diabetic (NOD) mice were use...AIM: To investigate the expression of interferon inducible protein-10 (IP-10) in pancreas of mice and to discuss its possible role in the pathogenesis of type 1 diabetes.METHODS: Non-obese diabetic (NOD) mice were used as experiment group and BALB/c mice as non-diabetic prone model. Immunohistochemistry method was used to evaluate the expression of IP-10 in the pancreas of NOD mice and BALB/c mice. Immunoelectron microscope was used to show the location of IP-10 in pancreatic islet β cells.RESULTS: Pancreatic islets were positively stained in all the NOD mice. Insulitis could be found in mice at the age of 4 wk. The weakly positive results were found in control group with no insulitis. Immunoelectron microscopy further demonstrated that IP-10 was produced by pancreatic β cells and stored in cytoplasm of the cells.CONCLUSION: IP-10 can be largely produced in pancreatic islets of NOD mice at the age of 2 wk when there is no significant insulitis, and may play an important part in the pathogenesis of type 1 diabetes by attracting immune cells to infiltrate the pancreatic islets.展开更多
Micro-texturing has been widely proven to be an effective technology for achieving sustainable machining.However,the performance of micro-textured tools under different cooling conditions,especially their coupling eff...Micro-texturing has been widely proven to be an effective technology for achieving sustainable machining.However,the performance of micro-textured tools under different cooling conditions,especially their coupling effect on machined surface integrity,was scarcely reported.In this paper,the non-textured,linear micro-grooved,and curvilinear micro-grooved inserts were used to turn aluminum alloy 6061 under dry,emulsion,and liquid nitrogen cryogenic cooling conditions.The coupling effects of different micro-textures and cooling conditions on cutting force,cutting temperature,and machined surface integrity,including the surface roughness,work hardening,and residual stress,were revealed and discussed in detail.Results indicated that the micro-grooved tools,especially the curvilinear micro-grooved tools,not only reduced the cutting force and cutting temperature,but also improved the machined surface integrity.In addition,the micro-grooved tools can cooperate with the emulsion or liquid nitrogen to reduce the cutting force,cutting temperature,and improve the machined surface integrity generally,although the combination of emulsion cooling condition and micro-grooved tools generated negative coupling effects on cutting forces and surface work hardening.Especially,the combination of curvilinear micro-grooved cutting tools and cryogenic cooling condition resulted in the lowest cutting force and cutting temperature,which generated the surface with low roughness,weak work hardening,and compressive residual stress.展开更多
With the development of artificial intelligence and robotics, the study on service robot has made a significant progress in recent years. Service robot is required to perceive users and environment in unstructured dom...With the development of artificial intelligence and robotics, the study on service robot has made a significant progress in recent years. Service robot is required to perceive users and environment in unstructured domestic environment. Based on the perception,service robot should be capable of understanding the situation and discover service task. So robot can assist humans for home service or health care more accurately and with initiative. Human can focus on the salient things from the mass observation information. Humans are capable of utilizing semantic knowledge to make some plans based on their understanding of the environment. Through intelligent space platform, we are trying to apply this process to service robot. A selective attention guided initiatively semantic cognition algorithm in intelligent space is proposed in this paper. It is specifically designed to provide robots with the cognition needed for performing service tasks. At first, an attention selection model is built based on saliency computing and key area. The area which is highly relevant to service task could be located and referred as focus of attention（FOA）. Second, a recognition algorithm for FOA is proposed based on a neural network. Some common objects and user behavior are recognized in this step. At last, a unified semantic knowledge base and corresponding reasoning engine is proposed using recognition result. Related experiments in a real life scenario demonstrated that our approach is able to mimic the recognition process in humans, make robots understand the environment and discover service task based on its own cognition. In this way, service robots can act smarter and achieve better service efficiency in their daily work.展开更多
文摘AIM: To investigate the expression of interferon inducible protein-10 (IP-10) in pancreas of mice and to discuss its possible role in the pathogenesis of type 1 diabetes.METHODS: Non-obese diabetic (NOD) mice were used as experiment group and BALB/c mice as non-diabetic prone model. Immunohistochemistry method was used to evaluate the expression of IP-10 in the pancreas of NOD mice and BALB/c mice. Immunoelectron microscope was used to show the location of IP-10 in pancreatic islet β cells.RESULTS: Pancreatic islets were positively stained in all the NOD mice. Insulitis could be found in mice at the age of 4 wk. The weakly positive results were found in control group with no insulitis. Immunoelectron microscopy further demonstrated that IP-10 was produced by pancreatic β cells and stored in cytoplasm of the cells.CONCLUSION: IP-10 can be largely produced in pancreatic islets of NOD mice at the age of 2 wk when there is no significant insulitis, and may play an important part in the pathogenesis of type 1 diabetes by attracting immune cells to infiltrate the pancreatic islets.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52005281,52005215 and 52074161)the Natural Science Foundation of Shandong Province(Grant No.ZR2020QE181)the Open Research Fund of State Key Laboratory of High Performance Complex Manufacturing,Central South University(Grant No.Kfkt2020-06).
文摘Micro-texturing has been widely proven to be an effective technology for achieving sustainable machining.However,the performance of micro-textured tools under different cooling conditions,especially their coupling effect on machined surface integrity,was scarcely reported.In this paper,the non-textured,linear micro-grooved,and curvilinear micro-grooved inserts were used to turn aluminum alloy 6061 under dry,emulsion,and liquid nitrogen cryogenic cooling conditions.The coupling effects of different micro-textures and cooling conditions on cutting force,cutting temperature,and machined surface integrity,including the surface roughness,work hardening,and residual stress,were revealed and discussed in detail.Results indicated that the micro-grooved tools,especially the curvilinear micro-grooved tools,not only reduced the cutting force and cutting temperature,but also improved the machined surface integrity.In addition,the micro-grooved tools can cooperate with the emulsion or liquid nitrogen to reduce the cutting force,cutting temperature,and improve the machined surface integrity generally,although the combination of emulsion cooling condition and micro-grooved tools generated negative coupling effects on cutting forces and surface work hardening.Especially,the combination of curvilinear micro-grooved cutting tools and cryogenic cooling condition resulted in the lowest cutting force and cutting temperature,which generated the surface with low roughness,weak work hardening,and compressive residual stress.
基金supported by National Natural Science Foundation of China (Nos. 61773239, 91748115 and 61603213)Natural Science Foundation of Shandong Province (No. ZR2015FM007)Taishan Scholars Program of Shandong Province
文摘With the development of artificial intelligence and robotics, the study on service robot has made a significant progress in recent years. Service robot is required to perceive users and environment in unstructured domestic environment. Based on the perception,service robot should be capable of understanding the situation and discover service task. So robot can assist humans for home service or health care more accurately and with initiative. Human can focus on the salient things from the mass observation information. Humans are capable of utilizing semantic knowledge to make some plans based on their understanding of the environment. Through intelligent space platform, we are trying to apply this process to service robot. A selective attention guided initiatively semantic cognition algorithm in intelligent space is proposed in this paper. It is specifically designed to provide robots with the cognition needed for performing service tasks. At first, an attention selection model is built based on saliency computing and key area. The area which is highly relevant to service task could be located and referred as focus of attention（FOA）. Second, a recognition algorithm for FOA is proposed based on a neural network. Some common objects and user behavior are recognized in this step. At last, a unified semantic knowledge base and corresponding reasoning engine is proposed using recognition result. Related experiments in a real life scenario demonstrated that our approach is able to mimic the recognition process in humans, make robots understand the environment and discover service task based on its own cognition. In this way, service robots can act smarter and achieve better service efficiency in their daily work.
