Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable...Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable morbidity and mortality worldwide.This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A(H7N9)and influenza A(H1N1)virus infections.Methods:: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2(n=83),H7N9(n=36),H1N1(n=44)viruses.Clinical presentation,chest CT features,and progression of patients were compared.We used the Logistic regression model to explore the possible risk factors.Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients(P<0.01),a higher complication rate,and more severe cases than H1N1 patients.H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients(P=0.01).H7N9 patients had similar patterns of lymphopenia,neutrophilia,elevated alanine aminotransferase,C-reactive protein,lactate dehydrogenase,and those seen in H1N1 patients,which were all significantly different from patients with COVID-19(P<0.01).Either H7N9 or H1N1 patients had more obvious symptoms,like fever,fatigue,yellow sputum,and myalgia than COVID-19 patients(P<0.01).The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9(P=0.78).For severe cases,the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9(P<0.01),the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9(P=0.02).Multivariate analysis showed that chronic heart disease was a possible risk factor(OR>1)for COVID-19,compared with H1N1 and H7N9.Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections,compared with H1N1.The meantime from illness onset to severity was shorter for H7N9.Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.展开更多
文摘Background: There is an urgent need to better understand the novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),for that the coronavirus disease 2019(COVID-19)continues to cause considerable morbidity and mortality worldwide.This paper was to differentiate COVID-19 from other respiratory infectious diseases such as avian-origin influenza A(H7N9)and influenza A(H1N1)virus infections.Methods:: We included patients who had been hospitalized with laboratory-confirmed infection by SARS-CoV-2(n=83),H7N9(n=36),H1N1(n=44)viruses.Clinical presentation,chest CT features,and progression of patients were compared.We used the Logistic regression model to explore the possible risk factors.Results: Both COVID-19 and H7N9 patients had a longer duration of hospitalization than H1N1 patients(P<0.01),a higher complication rate,and more severe cases than H1N1 patients.H7N9 patients had higher hospitalization-fatality ratio than COVID-19 patients(P=0.01).H7N9 patients had similar patterns of lymphopenia,neutrophilia,elevated alanine aminotransferase,C-reactive protein,lactate dehydrogenase,and those seen in H1N1 patients,which were all significantly different from patients with COVID-19(P<0.01).Either H7N9 or H1N1 patients had more obvious symptoms,like fever,fatigue,yellow sputum,and myalgia than COVID-19 patients(P<0.01).The mean duration of viral shedding was 9.5 days for SARS-CoV-2 vs 9.9 days for H7N9(P=0.78).For severe cases,the meantime from illness onset to severity was 8.0 days for COVID-19 vs 5.2 days for H7N9(P<0.01),the comorbidity of chronic heart disease was more common in the COVID-19 patients than H7N9(P=0.02).Multivariate analysis showed that chronic heart disease was a possible risk factor(OR>1)for COVID-19,compared with H1N1 and H7N9.Conclusions: The proportion of severe cases were higher for H7N9 and SARS-CoV-2 infections,compared with H1N1.The meantime from illness onset to severity was shorter for H7N9.Chronic heart disease was a possible risk factor for COVID-19.The comparison may provide the rationale for strategies of isolation and treatment of infected patients in the future.
