Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influ...Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this study.Results It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients,respectively(P < 0.05).Moreover,the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients(P < 0.01).The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T cells.Additionally,the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T cells.Conclusions Both younger and severe patients are associated with higher viral loads and longer viral shedding periods,which may partially be attributed to the impaired Th17 cell response.展开更多
Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that ...Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP).展开更多
A redox-active tetrazine moiety is immobilized within a metal-organic framework(MOF)aiming at targeted construction of a cathode with improved performance for lithium–oxygen batteries.A 1,2,4,5-tetrazine(Tz)functiona...A redox-active tetrazine moiety is immobilized within a metal-organic framework(MOF)aiming at targeted construction of a cathode with improved performance for lithium–oxygen batteries.A 1,2,4,5-tetrazine(Tz)functionalized ligand is used to construct a nanoporous MOF,Tz-Mg-MOF-74,in which the redox activity of the Tz moiety is retained.Combining the redox activity of Tz with the porous nature of a MOF produced a Tz-Mg-MOF-74-based cathode with significantly improved electrochemical performance.Specifically,the material has improved sustainable capacity with a lower overpotential compared with otherwise similar batteries without Tz and other reported MOF-based catalysts.The present approach productively integrates electrochemical activity derived from redox-active moieties and MOFs,and this combination opens a new avenue for the design of effective materials for energy storage and conversion.展开更多
Transparency Ecosystem for Research and Journals in Medicine(TERM)working group summarized the essential recommendations that should be considered to review and publish a high-quality guideline.These recommendations f...Transparency Ecosystem for Research and Journals in Medicine(TERM)working group summarized the essential recommendations that should be considered to review and publish a high-quality guideline.These recommendations from editors and reviewers included 10 components of essential requirements:systematic review of existing relevant guidelines,guideline registration,guideline protocol,stakeholders,conflicts of interest,clinical questions,systematic reviews,recommendation consensus,guideline reporting and external review.TERM working group abbreviates them as PAGE(essential requirements for Publishing clinical prActice GuidelinEs),and recommends guideline authors,editors,and peer reviewers to use them for high-quality guidelines.展开更多
文摘Objective To explore whether age,disease severity,cytokines and lymphocytes in H1N1 influenza A patients correlate with viral load and clearance.Methods Total of 70 mild and 16 severe patients infected with H1N1 influenza A virus were enrolled in this study.Results It was found that the patients under 14 years old and severe patients displayed significantly higher viral loads and prolonged viral shedding periods compared with the patients over 14 years old and mild patients,respectively(P < 0.05).Moreover,the patients under 14 years old and severe patients displayed significantly lower Th17 cell frequency than the patients over 14 years old and mild patients(P < 0.01).The viral shedding period inversely correlated with the frequency of IL-17+IFN-γ-CD4+ T cells.Additionally,the decreased concentration of serum TGF-β correlated with the decreased frequency of IL-17+IFN-γ-CD4+ T cells.Conclusions Both younger and severe patients are associated with higher viral loads and longer viral shedding periods,which may partially be attributed to the impaired Th17 cell response.
文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP).
基金supported by the NSFC(nos.21421001,21531005,21905142,and 21671112)the Program of Introducing Talents of Discipline to Universities(no.B18030)+1 种基金the Natural Science Fund of Tianjin(nos.19JCZDJC37200 and 19JCQNJC02600)China.The authors thank Professor Brian Space(University of South Florida,Tampa,FL)for discussion and help.
文摘A redox-active tetrazine moiety is immobilized within a metal-organic framework(MOF)aiming at targeted construction of a cathode with improved performance for lithium–oxygen batteries.A 1,2,4,5-tetrazine(Tz)functionalized ligand is used to construct a nanoporous MOF,Tz-Mg-MOF-74,in which the redox activity of the Tz moiety is retained.Combining the redox activity of Tz with the porous nature of a MOF produced a Tz-Mg-MOF-74-based cathode with significantly improved electrochemical performance.Specifically,the material has improved sustainable capacity with a lower overpotential compared with otherwise similar batteries without Tz and other reported MOF-based catalysts.The present approach productively integrates electrochemical activity derived from redox-active moieties and MOFs,and this combination opens a new avenue for the design of effective materials for energy storage and conversion.
基金supported by the Foundation of Chinese Medical Association Publishing House.
文摘Transparency Ecosystem for Research and Journals in Medicine(TERM)working group summarized the essential recommendations that should be considered to review and publish a high-quality guideline.These recommendations from editors and reviewers included 10 components of essential requirements:systematic review of existing relevant guidelines,guideline registration,guideline protocol,stakeholders,conflicts of interest,clinical questions,systematic reviews,recommendation consensus,guideline reporting and external review.TERM working group abbreviates them as PAGE(essential requirements for Publishing clinical prActice GuidelinEs),and recommends guideline authors,editors,and peer reviewers to use them for high-quality guidelines.
