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帕瑞昔布钠超前镇痛对人工膝关节置换术后患者镇痛、炎症因子及认知功能的影响 被引量:15
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作者 刘选泽 肖国庆 +1 位作者 钟喜红 程劲 《中国现代医学杂志》 CAS 北大核心 2021年第17期29-35,共7页
目的探究帕瑞昔布钠超前镇痛对换膝骨关节炎人工膝关节置换患者术后镇痛、炎症因子及认知功能的影响。方法选取2017年1月—2019年9月成都医学院第二附属医院就诊的膝骨关节炎患者共100例,全部行人工膝关节置换术,随机将其分为实验组和... 目的探究帕瑞昔布钠超前镇痛对换膝骨关节炎人工膝关节置换患者术后镇痛、炎症因子及认知功能的影响。方法选取2017年1月—2019年9月成都医学院第二附属医院就诊的膝骨关节炎患者共100例,全部行人工膝关节置换术,随机将其分为实验组和对照组,每组50例。对照组不予以任何超前镇痛,实验组麻醉前静脉注射帕瑞昔布钠40 mg,两组术后均静脉注射舒芬太尼自控镇痛。分别于术前1 h、术后6 h、术后12 h、术后24 h、术后48 h采用视觉模拟评分(VAS)进行疼痛评分;HSS膝关节功能评分法对膝关节功能进行评分;简易智力状态检查量表(MMSE)进行认知功能评分。酶联免疫吸附试验(ELISA)测定各时间点血清中IL-6、IL-10、TNF-α的表达水平。结果两组患者术后VAS评分随着时间延长逐渐降低,其中实验组在术后6 h、12 h、24 h及48 h评分与对照组比较,差异有统计学意义(P<0.05),实验组低于对照组;两组HSS膝关节评分随着时间延长逐渐升高,实验组在术后12 h、24 h及48 h评分与对照组比较,差异有统计学意义(P<0.05),实验组低于对照组;术后两组患者的IL-6、TNF-α水平均升高,但实验组在术后各时间点的水平较对照组低(P<0.05);两组患者术后IL-10水平均降低,但实验组在术后各时间点的水平较对照组高(P<0.05)。两组术后早期认知功能评分均下降,但实验组术后6 h、12 h、24 h及48 h评分较对照组高(P<0.05)。实验组的不良反应总发生率为6.0%,低于对照组的不良反应总发生率16.0%。结论帕瑞昔布钠超前镇痛对实施人工膝关节置换术的膝骨关节炎患者的术后镇痛效果良好,术后炎症因子水平降低,抗炎因子水平升高,炎症反应减少,有效保护患者认知功能,且不良反应少,可推广应用于临床。 展开更多
关键词 膝骨关节炎 帕瑞昔布钠 超前镇痛 人工膝关节置换术 炎症因子 认知功能
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关节镜下钢丝引导缝合联合微骨折术修复膝关节外侧半月板后根部撕裂对膝关节本体感觉的影响 被引量:7
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作者 刘选泽 肖国庆 +1 位作者 钟喜红 程劲 《中国现代医学杂志》 CAS 北大核心 2021年第4期26-30,共5页
目的分析关节镜下钢丝引导缝合联合微骨折术修复膝关节外侧半月板后根部撕裂对膝关节本体感觉的影响。方法选取2015年3月—2018年2月成都医学院第二附属医院收治的膝关节外侧半月板后根部撕裂患者118例作为研究对象。根据手术方式分为... 目的分析关节镜下钢丝引导缝合联合微骨折术修复膝关节外侧半月板后根部撕裂对膝关节本体感觉的影响。方法选取2015年3月—2018年2月成都医学院第二附属医院收治的膝关节外侧半月板后根部撕裂患者118例作为研究对象。根据手术方式分为观察组60例和对照组58例。对照组行保守治疗,观察组采用关节镜下钢丝引导缝合联合微骨折术治疗。比较两组治疗前后视觉模拟评分(VAS)评分、国际膝关节评分委员会(IKDC)评分及Lysholm膝关节功能评分;分析观察组并发症发生情况。两组均接受1年随访,比较两组膝关节本体感觉测试的差值。结果观察组治疗前后VAS评分的差值高于对照组(P<0.05)。观察组治疗前后的Lysholm膝关节功能评分、IKDC评分的差值高于对照组(P<0.05)。观察组治疗前后15°、45°及75°时的膝关节本体感觉测试差值的差值低于对照组(P<0.05)。观察组与对照组并发症发生率分别为0.00%和13.79%,观察组低于对照组(P<0.05)。结论关节镜下钢丝引导缝合联合微骨折术治疗膝关节外侧半月板后根部撕裂的效果理想,有利于改善膝关节本体感觉。 展开更多
关键词 撕裂伤 膝关节 关节镜检查 骨折手术 膝关节本体感觉 疾病影响状态调查
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Differences in MBUs induced by high-energy and medium-energy heavy ions in 28 nm FPGAs 被引量:1
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作者 Shuai Gao Jin-Hu Yang +7 位作者 Bing Ye Chang Cai Ze He Jie Liu Tian-Qi Liu xiao-Yu Yan You-Mei Sun guo-qing xiao 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2022年第9期28-36,共9页
Multiple-bit upsets(MBUs)have become a threat to modern advanced field-programmable gate arrays(FPGAs)applications in radiation environments.Hence,many investigations have been conducted using mediumenergy heavy ions ... Multiple-bit upsets(MBUs)have become a threat to modern advanced field-programmable gate arrays(FPGAs)applications in radiation environments.Hence,many investigations have been conducted using mediumenergy heavy ions to study the effects of MBU radiation.However,high-energy heavy ions(HEHIs)greatly affect the size and percentage of MBUs because their ionizationtrack structures differ from those of medium-energy heavy ions.In this study,the different impacts of high-energy and medium-energy heavy ions on MBUs in 28 nm FPGAs as well as their mechanisms are thoroughly investigated.With the Geant4 calculation,more serious energy effects of HEHIs on MBU scales were successfully demonstrated.In addition,we identified worse MBU responses resulting from lowered voltages.The MBU orientation effect was observed in the radiation of different dimensions.The broadened ionization tracks for tilted tests in different dimensions could result in different MBU sizes.The results also revealed that the ionization tracks of tilted HEHIs have more severe impacts on the MBU scales than mediumenergy heavy ions with much higher linear energy transfer.Therefore,comprehensive radiation with HEHIs is indispensable for effective hardened designs to apply highdensity 28 nm FPGAs in deep space exploration. 展开更多
关键词 FPGA High-energy heavy-ion radiation MBU Ionization track
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糖尿病致动脉粥样硬化的相关途径及中西医治疗进展 被引量:1
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作者 肖国庆 康学东 易希善 《数理医药学杂志》 CAS 2023年第4期307-315,共9页
糖尿病和动脉粥样硬化都具有起病隐匿、发展缓慢的临床特点,常因失治误治而发生难以挽回的不良结局。动脉粥样硬化发病原因复杂多样,最终皆因炎症反应破坏内皮细胞结构与功能,而导致动脉粥样硬化的发生。许多研究发现糖尿病与动脉粥样... 糖尿病和动脉粥样硬化都具有起病隐匿、发展缓慢的临床特点,常因失治误治而发生难以挽回的不良结局。动脉粥样硬化发病原因复杂多样,最终皆因炎症反应破坏内皮细胞结构与功能,而导致动脉粥样硬化的发生。许多研究发现糖尿病与动脉粥样硬化的发生有一定的关联性,动脉粥样硬化在糖尿病之后更易发生,并且与心血管疾病的发展更是关系密切。西医治疗糖尿病合并动脉粥样硬化具有一定的局限性。近年来,关于糖尿病合并动脉粥样硬化的中医治疗研究越来越多且取得良好结果,为糖尿病合并动脉粥样硬化的治疗及心血管疾病的防治提供了新的依据。 展开更多
关键词 糖尿病 动脉粥样硬化 中西医结合 糖代谢 血脂紊乱
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A high-throughput screening method for breeding Aspergillus niger with 12C6+ ion beam-improved cellulase
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作者 Bo-Ling Jiang Shu-Yang Wang +7 位作者 Yu-Chen Wang Ji-Hong Chen Wen-Jian Li Jing Liu Wei Hu guo-qing xiao Miao-Ying Dong Fu-Qiang Xu 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第1期1-7,共7页
In this study,a high-throughput screening method was established through the 24-square deep-well microliter plate(MTP) fermentation and micro-plate detection for large-scale screening of the mutants.It was suitable fo... In this study,a high-throughput screening method was established through the 24-square deep-well microliter plate(MTP) fermentation and micro-plate detection for large-scale screening of the mutants.It was suitable for screening a large number of mutants and improving the breeding efficiency after heavy-ion beam irradiation.Seventeen strains showed higher cellulase activity compared with the initial strain after the screening of plate and MTP fermentation.The filter paper activity and β-glucosidase activity of Aspergillus niger H11201 had increased 38.74 and 63.23%separately compared with A.niger H11 by shaking flask fermentation,and it was genetically stable after being passaged to nine generations.The results indicate that the high-throughput screening method can be used for the quick breeding of A.niger with high cellulase activity. 展开更多
关键词 HIGH-THROUGHPUT screening method ASPERGILLUS NIGER H11 CELLULASE 12C6+ ion beam
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An active base designed in high-counting-rate applications for Hamamatsu R1924A photomultiplier tube
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作者 Pei-Pei Ren Wei-Ping Lin +10 位作者 Roy Wada Xing-Quan Liu Mei-Rong Huang Guo-Yu Tian Fei Luo Qi Sun Zhi-Qiang Chen guo-qing xiao Rui Han Fu-Dong Shi Bo-Xing Gou 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第10期59-63,共5页
Hamamatsu R1924A is one of the most widely used photomultiplier tubes(PMTs) in nuclear physics.Since the active base suitable for R1924A is still not available in market, an active base is designed for Hamamatsu R1924... Hamamatsu R1924A is one of the most widely used photomultiplier tubes(PMTs) in nuclear physics.Since the active base suitable for R1924A is still not available in market, an active base is designed for Hamamatsu R1924A PMT, and the test results at high counting rates are presented. The active bases with two different sets of resistor chains were tested and compared by a frequency-controlled green straw hat LED light. A stable signal output up to 100 kHz is achieved using frequency-controlled LED pulsed light. The temperature of bases, which reflects the power consumption and is crucial for applications in vacuum, is also monitored with the same LED pulsed light. The temperature of the active base with smaller resistances reaches about twice of that of the active base with larger resistances in the resistor chain. For the applications in vacuum, the active base with resistance between the two sets of resistor chains may be preferable. 展开更多
关键词 光电倍增管 高计数率 应用 设计 活性基团 LED灯 频率控制
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Recent progress in synthesis of composite powders and their applications in low-carbon refractories 被引量:5
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作者 Ji-yuan Luo Xin-ming Ren +4 位作者 xiao-chuan Chong Dong-hai Ding Bei-yue Ma guo-qing xiao Jing-kun Yu 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2022年第7期1041-1051,共11页
The development of low-carbon refractories is of great significance,but it is limited by the deteriorated properties that resulted from the decreased graphite content.Incorporating composite powders has proved to be e... The development of low-carbon refractories is of great significance,but it is limited by the deteriorated properties that resulted from the decreased graphite content.Incorporating composite powders has proved to be effective in improving the properties of low-carbon refractories.The recent progress in the synthesis of composite powders including modified graphite,nanocarbon-containing composite powders,oxide/non-oxide and non-oxide composite powders and their applications in low-carbon refractories were reviewed,and the future development of composite powder technology was prospected. 展开更多
关键词 Composite powder Modified graphite Nanocarbon-containing composite powder Oxide/non-oxide Non-oxide Low-carbon refractory
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