We summarize the most important advances in RNA delivery and nanomedicine.We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs.The fundamental properties of the key R...We summarize the most important advances in RNA delivery and nanomedicine.We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs.The fundamental properties of the key RNA members are described.We introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of cancer.This review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology.展开更多
As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemis...As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results.Owing to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional biomaterials.On one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of drugs.On the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability.In this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,etc.By introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are described.Future challenges and directions of this field are also outlined.展开更多
A symmetric pillararene-based receptor containing ten triazole units was synthesized.Interestingly,it formed 1:1 complexes instead of 1:2 with different halide anions.This was caused by the cooperative multivalent hyd...A symmetric pillararene-based receptor containing ten triazole units was synthesized.Interestingly,it formed 1:1 complexes instead of 1:2 with different halide anions.This was caused by the cooperative multivalent hydrogen-bond interactions between the triazole protons on one side of the receptor and the halide anion,which changed its structure from pillar to conical.However,by the regulation of the effector F-,it can work like an excavator grapple selectively grasps a PF6-anion.展开更多
基金support of the National Key Research and Development Program of China (No.2019YFC1315701)National Natural Science Foundation of China (No.22005343)+4 种基金Cancer Hospital,Chinese Academy of Medical SciencesShenzhen Center/Shenzhen Cancer Hospital Research Project (No.SZ2020ZD004,China)Shenzhen Science and Technology Program (No.KCXFZ20201221173008022,China)Sanming Project of Medicine in Shenzhen (Nos.SZSM201812062 and SZSM201612097,China)Shenzhen Key Medical Discipline Construction Fund (No.SZXK075,China)
文摘We summarize the most important advances in RNA delivery and nanomedicine.We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs.The fundamental properties of the key RNA members are described.We introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of cancer.This review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology.
基金This work was supported by the National Natural Science Foundation of China(22035006)This publication is based in part upon work supported by the King Abdullah University of Science and Technology Office of Sponsored Research(OSR-2019-CRG8-4032).
文摘As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results.Owing to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional biomaterials.On one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of drugs.On the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability.In this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,etc.By introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are described.Future challenges and directions of this field are also outlined.
基金supported by the National Natural Science Foundation of China(Nos.21572042 and 21773052)the Program for Innovative Research Team in Chinese University(No.IRT 1231)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(Nos.LZ16B020002 and LQ17B040002)the Pandeng Plan Foundation of Hangzhou Normal University for Youth Scholars of Materials,Chemistry and Chemical Engineering
文摘A symmetric pillararene-based receptor containing ten triazole units was synthesized.Interestingly,it formed 1:1 complexes instead of 1:2 with different halide anions.This was caused by the cooperative multivalent hydrogen-bond interactions between the triazole protons on one side of the receptor and the halide anion,which changed its structure from pillar to conical.However,by the regulation of the effector F-,it can work like an excavator grapple selectively grasps a PF6-anion.