Imaging characteristics of two patients with isolated cortical venous thrombosis

Over the past twenty years, improvements in neuroimaging have greatly improved the ability to diagnose cerebral venous sinus thrombosis, as well as isolated cortical venous thrombosis. Neuroimaging allows for variations to be detected in the cortical vein and venous sinus. Diagnosis of thromboses in the venous system should not depend entirely on angiography of undeveloped veins or venous sinus. Currently, the combination of magnetic resonance imaging and magnetic resonance venography is the gold standard for diagnosing cerebral venous sinus thrombosis, rather than digital subtraction angiography. This article summarizes clinical manifestations, results from computed tomography and magnetic resonance imaging in two cases of isolated cortical venous thrombosis, analyzed relevant literature, and discussed the clinical and imaging characteristics of isolated cortical venous thromboses.

Imaging Analysis of Primary Malignant Intracranial Lymphoma

OBJECTIVE To investigate the images characteristics of primarymalignant intracranial lymphoma .METHODS Retrospective study was conducted on CT/MRIimaging characteristics of 9 cases with primary malignantintracranial lymphoma.RESULTS The patients had lesions mostly in the supratentorialregion, including the parts of deep white matter, para-ependymalregions, and corpus callosum. The shapes of the lesions wereround or irregular. CT scan showed equal or slightly high densityof the tumor images, compared with the normal tissue in the brain.The T1 WI of MRI scan on the tumor showed low signal and theT2WI showed equal or slightly high signal. The MRI signals werehomogenous. Cystic lesion, calcification, and hemorrhage wererarely seen in MRI. Edema around tumor and its occupationaleffect was lessened. Edema around tumor shown in MRI was notin accordance with the true volume of the tumor mass. Enhancedscan on the lesions showed homogenous enhancement, and thepia mater invaded and/or the spread along ependyma.CONCLUSION Images of primary malignant intracraniallymphoma have specific characteristics that are useful in itsdiagnosis and differential diagnosis.

Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms

ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804 A may influence brain activity by interacting with COMT.Here,we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants.Amplitudes of low-frequency fluctuations(ALFFs)were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680.The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 x COMT rs4680 interaction,manifesting as a U-shaped modulation,presumably by dopamine signaling.Significant main effects were also found.These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT,and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.