Background:Gastric cancer(GC)is a malignancy with the worst prognosis that seriously threatens human health,especially in East Asia.Apolipoprotein C1(apoc1)belongs to the apolipoprotein family.In addition,apoc1 has be...Background:Gastric cancer(GC)is a malignancy with the worst prognosis that seriously threatens human health,especially in East Asia.Apolipoprotein C1(apoc1)belongs to the apolipoprotein family.In addition,apoc1 has been associated with various tumors.However,its role in GC remains unclear.Methods:Firstly,we quantified its expression in GC and adjacent tumor tissues,using The Cancer Genome Atlas(TCGA).Next,we assessed cell invasion and migration abilities.Finally,we revealed the role of apoc1 in the tumor microenvironment(TME),immune cell infiltration and drug sensitivity.Results:Firstly,in TCGA database,it has been shown that elevated expression of apoc1 was identified in various cancers,including GC,then we found that high expression of apoc1 was significantly correlated with poor prognosis in GC.Histologically,apoc1 expression is proportional to grade,cancer stage,and T stage.The experimental results showed that apoc1 promoted cell invasion and migration.Then GO,KEGG,and GSEA pathway analyses indicated that apoc1 may be involved in the WNT pathway and immune regulation.Furthermore,we found out the tumor-infiltrating immune cells related to apoc1 in the tumor microenvironment(TME)using TIMER.Finally,we investigated the correlation between apoc1 expression and drug sensitivity,PD-1 and CTLA-4 therapy.Conclusions:These results suggest that apoc1 participates in the evolution of GC,and may represent a potential target for detection and immunotherapy in GC.展开更多
The research purpose is to accurately reveal the temporal and spatial law of the urban expansion of Changsha-Zhuzhou-Xiangtan, one of the seven major urban agglomeration areas in China, and provide decision-making bas...The research purpose is to accurately reveal the temporal and spatial law of the urban expansion of Changsha-Zhuzhou-Xiangtan, one of the seven major urban agglomeration areas in China, and provide decision-making basis for the future urban construction land layout and regional development policy-making. Based on the night lighting data (DMSP/OLS), this paper extracts the boundary of the urban construction land of Changsha-Zhuzhou-Xiangtan urban agglomeration from 1993 to 2017, and quantitatively studies the spatial and temporal characteristics of the expansion of the metropolitan area in the past 25 years according to the methods of spatial expansion analysis, center of gravity migration measurement, landscape pattern index, spatial autocorrelation, etc. The results show that: 1) it is scientific and feasible to extract urban agglomeration construction land by the method of auxiliary data comparison for the study of urban expansion;2) the expansion of regional space in Changsha-Zhuzhou-Xiangtan metropolitan area shows a trend of “weakening first and strengthening later”. The construction land keeps increasing, and the expansion form gradually changes from extensive type to intensive type;3) the center of gravity of the metropolitan area fluctuated and repeated in part during the past 25 years, but it was always located in the municipal district of Changsha city. The eastern region, mainly Changsha city, was still the core area of urban agglomeration expansion;4) strengthening the territorial space protection and control of ecological green core in the metropolitan area is a key measure for the high-quality development of urban agglomeration.展开更多
In this study, we performed an integrated investigation of K and Mg isotopes in hydrothermally altered rocks from the giant Dexing porphyry Cu deposit in China. Both the altered porphyry intrusion and the surrounding ...In this study, we performed an integrated investigation of K and Mg isotopes in hydrothermally altered rocks from the giant Dexing porphyry Cu deposit in China. Both the altered porphyry intrusion and the surrounding wall rocks exhibit large variations in K and Mg isotope compositions, with δ41K values ranging between-1.02‰ and 0.38‰, and δ26Mg values ranging between-0.49‰ and 0.32‰. The δ41K and δ26Mg values of the majority of altered samples are higher than the isotopic baseline values for upper continental crust. We attribute the general increase in δ41 K and δ26Mg in altered rocks to hydrothermal alteration,which caused preferential incorporation of heavy K and Mg isotopes in alteration products, particularly phyllosilicates. However,a few altered samples show anomalously low δ41K and δ26Mg values. The δ41K and δ26Mg values do not correlate with K and Mg concentrations, or mineralogy of altered samples. The variable K-Mg isotope data likely reflect fluids of different physicalchemical properties, or different isotopic compositions. Based on the combined K-Mg isotope data, at least three groups of hydrothermal fluids are distinguished from the Dexing porphyry deposit. Therefore, K-Mg isotopes are potentially a novel tracer for fingerprinting fluids in complex hydrothermal systems.展开更多
基金financed by the National Natural Science Foundation(Grant Number 81874058 to Jianping Zhang).
文摘Background:Gastric cancer(GC)is a malignancy with the worst prognosis that seriously threatens human health,especially in East Asia.Apolipoprotein C1(apoc1)belongs to the apolipoprotein family.In addition,apoc1 has been associated with various tumors.However,its role in GC remains unclear.Methods:Firstly,we quantified its expression in GC and adjacent tumor tissues,using The Cancer Genome Atlas(TCGA).Next,we assessed cell invasion and migration abilities.Finally,we revealed the role of apoc1 in the tumor microenvironment(TME),immune cell infiltration and drug sensitivity.Results:Firstly,in TCGA database,it has been shown that elevated expression of apoc1 was identified in various cancers,including GC,then we found that high expression of apoc1 was significantly correlated with poor prognosis in GC.Histologically,apoc1 expression is proportional to grade,cancer stage,and T stage.The experimental results showed that apoc1 promoted cell invasion and migration.Then GO,KEGG,and GSEA pathway analyses indicated that apoc1 may be involved in the WNT pathway and immune regulation.Furthermore,we found out the tumor-infiltrating immune cells related to apoc1 in the tumor microenvironment(TME)using TIMER.Finally,we investigated the correlation between apoc1 expression and drug sensitivity,PD-1 and CTLA-4 therapy.Conclusions:These results suggest that apoc1 participates in the evolution of GC,and may represent a potential target for detection and immunotherapy in GC.
文摘The research purpose is to accurately reveal the temporal and spatial law of the urban expansion of Changsha-Zhuzhou-Xiangtan, one of the seven major urban agglomeration areas in China, and provide decision-making basis for the future urban construction land layout and regional development policy-making. Based on the night lighting data (DMSP/OLS), this paper extracts the boundary of the urban construction land of Changsha-Zhuzhou-Xiangtan urban agglomeration from 1993 to 2017, and quantitatively studies the spatial and temporal characteristics of the expansion of the metropolitan area in the past 25 years according to the methods of spatial expansion analysis, center of gravity migration measurement, landscape pattern index, spatial autocorrelation, etc. The results show that: 1) it is scientific and feasible to extract urban agglomeration construction land by the method of auxiliary data comparison for the study of urban expansion;2) the expansion of regional space in Changsha-Zhuzhou-Xiangtan metropolitan area shows a trend of “weakening first and strengthening later”. The construction land keeps increasing, and the expansion form gradually changes from extensive type to intensive type;3) the center of gravity of the metropolitan area fluctuated and repeated in part during the past 25 years, but it was always located in the municipal district of Changsha city. The eastern region, mainly Changsha city, was still the core area of urban agglomeration expansion;4) strengthening the territorial space protection and control of ecological green core in the metropolitan area is a key measure for the high-quality development of urban agglomeration.
基金supported by the National Key R & D Program of China (Grant No. 2018YFC0604106)the National Natural Science Foundation of China (Grant Nos. 41622301, 41873004)
文摘In this study, we performed an integrated investigation of K and Mg isotopes in hydrothermally altered rocks from the giant Dexing porphyry Cu deposit in China. Both the altered porphyry intrusion and the surrounding wall rocks exhibit large variations in K and Mg isotope compositions, with δ41K values ranging between-1.02‰ and 0.38‰, and δ26Mg values ranging between-0.49‰ and 0.32‰. The δ41K and δ26Mg values of the majority of altered samples are higher than the isotopic baseline values for upper continental crust. We attribute the general increase in δ41 K and δ26Mg in altered rocks to hydrothermal alteration,which caused preferential incorporation of heavy K and Mg isotopes in alteration products, particularly phyllosilicates. However,a few altered samples show anomalously low δ41K and δ26Mg values. The δ41K and δ26Mg values do not correlate with K and Mg concentrations, or mineralogy of altered samples. The variable K-Mg isotope data likely reflect fluids of different physicalchemical properties, or different isotopic compositions. Based on the combined K-Mg isotope data, at least three groups of hydrothermal fluids are distinguished from the Dexing porphyry deposit. Therefore, K-Mg isotopes are potentially a novel tracer for fingerprinting fluids in complex hydrothermal systems.
