Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells(HSCs)have become the gold standard for defining the properties of adult stem cells(ASCs).Here,we describe ...Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells(HSCs)have become the gold standard for defining the properties of adult stem cells(ASCs).Here,we describe the“self-renewal,multilineage differentiation,apoptosis,rest,and trafficking”or“SMART”model,which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.Given the potential therapeutic applications of ASCs,we delineate the key characteristics of HSCs using this model and speculate on the physiological relevance of stem cells identified in other tissues.Great strides are being made in understanding the biology of ASCs,and efforts are now underway to develop safe and effective ASC-based therapies in this emerging area.展开更多
Dear Editor,Most cancer cells maintain the length of their telomeres via telomerase(Günes and Rudolph,2013;Kim et al.,1994).However,in some cancers,telomeres are maintained not by telomerase but by alternative le...Dear Editor,Most cancer cells maintain the length of their telomeres via telomerase(Günes and Rudolph,2013;Kim et al.,1994).However,in some cancers,telomeres are maintained not by telomerase but by alternative lengthening of telomeres(Bryan et al.,1997).Telomerase activity appears to be reduced in some bone marrow(BM)diseases,including chronic myeloid leukemia,acute myeloid leukemia(AML),and myeloproliferative neoplasms(MPN),leading to shortened telomeres that correlate with leukemogenesis(Bouillon et al.,2018;Engelhardt et al.,2000;Shay et al.,1996).Our current study aimed to determine the definitive roles of telomeres and telomerase in leukemogenesis.展开更多
基金supported by the Ministry of Science and Technology of China(2016YFA0100600,2017YFA0103400,2020YFE0203000)the National Natural Science Foundation of China(81922002,81730006,81890990,81870086,82070112)+1 种基金the CAMS Initiative for Innovative Medicine(2017-I2M-3-009,2016-I2M-1-017)Distinguished Young Scholars of Tianjin(19JCJQJC63400)。
文摘Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells(HSCs)have become the gold standard for defining the properties of adult stem cells(ASCs).Here,we describe the“self-renewal,multilineage differentiation,apoptosis,rest,and trafficking”or“SMART”model,which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.Given the potential therapeutic applications of ASCs,we delineate the key characteristics of HSCs using this model and speculate on the physiological relevance of stem cells identified in other tissues.Great strides are being made in understanding the biology of ASCs,and efforts are now underway to develop safe and effective ASC-based therapies in this emerging area.
基金supported by the National Key Research and Development Program of China(2016YFA0100600,2017YFA0103400)the National Natural Science Foundation of China(81421002,81730006,81430004,81870086,8181101081)+1 种基金CAMS Initiative for Innovative Medicine(2017-I2M-3-009,2016-I2M-1-017)the CAMS Fundamental Research Funds for Central Research Institutes(2018PT31005)。
文摘Dear Editor,Most cancer cells maintain the length of their telomeres via telomerase(Günes and Rudolph,2013;Kim et al.,1994).However,in some cancers,telomeres are maintained not by telomerase but by alternative lengthening of telomeres(Bryan et al.,1997).Telomerase activity appears to be reduced in some bone marrow(BM)diseases,including chronic myeloid leukemia,acute myeloid leukemia(AML),and myeloproliferative neoplasms(MPN),leading to shortened telomeres that correlate with leukemogenesis(Bouillon et al.,2018;Engelhardt et al.,2000;Shay et al.,1996).Our current study aimed to determine the definitive roles of telomeres and telomerase in leukemogenesis.
