The swine flu, H1N1 virus was outbroken in Mexico and the United States in April 2009 and then rapidly spread worldwide. The World Health Organization declared that the outbreak of influenza is caused by a new subtype...The swine flu, H1N1 virus was outbroken in Mexico and the United States in April 2009 and then rapidly spread worldwide. The World Health Organization declared that the outbreak of influenza is caused by a new subtype of influenza H1N1 influenza virus. And researchers have isolated some oseltamivir resistance strains in 2009 swine flu which makes the imminency of research and development of new anti influenza drug. The CPSF30 binding pocket of effector domain in NS1 protein is very important in the replication of influanza A virus and is a new attractive anti flu drug target. But up to now there is no antiviral drug target this pocket. Here we employ molecular docking to screening of about 200,000 compounds. We find four novel compounds with high binding energy. Binding comformation analysis revealed that these small molecules can interact with the binding pocket by some strong hydrophobic interaction. This study find some novel small molecules can be used as lead compounds in the development of new antiinfluenza drug based on CPSF30 pocket.展开更多
What is already known on this topic?To understand the status of the diagnosis and reporting of hepatitis C and standardize the reporting of hepatitis C cases in county-level hospitals,we conducted the first supervised...What is already known on this topic?To understand the status of the diagnosis and reporting of hepatitis C and standardize the reporting of hepatitis C cases in county-level hospitals,we conducted the first supervised analysis of hepatitis C cases in county-level hospitals in China from 2013 to 2018,covering all provincial-level administrative divisions(PLADs)except Tibet.What is added by this report?Through 6 years of supervision,we have obtained key data such as the nucleic acid detection rate and positive rate of hepatitis C virus(HCV)antibody positive cases in our county-level hospitals,the report rate and accuracy of HCV RNA positive cases,and standardized and improved the hepatitis C case reporting in countylevel hospitals to improve data quality and provide data support for the judgment and estimation of hepatitis C in China.What are the implications for public health practice?By strengthening the management and supervision of hepatitis C case reporting,the reporting rate and accuracy of HCV RNA positive cases in county-level hospitals in China had been greatly improved.By combining the number of HCV antibody tests and the number of viral nucleic acid tests in medical institutions around the country,it was possible to effectively assess the current status of hepatitis C in China and to provide a scientific basis for the development of hepatitis C prevention and treatment measures.展开更多
文摘The swine flu, H1N1 virus was outbroken in Mexico and the United States in April 2009 and then rapidly spread worldwide. The World Health Organization declared that the outbreak of influenza is caused by a new subtype of influenza H1N1 influenza virus. And researchers have isolated some oseltamivir resistance strains in 2009 swine flu which makes the imminency of research and development of new anti influenza drug. The CPSF30 binding pocket of effector domain in NS1 protein is very important in the replication of influanza A virus and is a new attractive anti flu drug target. But up to now there is no antiviral drug target this pocket. Here we employ molecular docking to screening of about 200,000 compounds. We find four novel compounds with high binding energy. Binding comformation analysis revealed that these small molecules can interact with the binding pocket by some strong hydrophobic interaction. This study find some novel small molecules can be used as lead compounds in the development of new antiinfluenza drug based on CPSF30 pocket.
文摘What is already known on this topic?To understand the status of the diagnosis and reporting of hepatitis C and standardize the reporting of hepatitis C cases in county-level hospitals,we conducted the first supervised analysis of hepatitis C cases in county-level hospitals in China from 2013 to 2018,covering all provincial-level administrative divisions(PLADs)except Tibet.What is added by this report?Through 6 years of supervision,we have obtained key data such as the nucleic acid detection rate and positive rate of hepatitis C virus(HCV)antibody positive cases in our county-level hospitals,the report rate and accuracy of HCV RNA positive cases,and standardized and improved the hepatitis C case reporting in countylevel hospitals to improve data quality and provide data support for the judgment and estimation of hepatitis C in China.What are the implications for public health practice?By strengthening the management and supervision of hepatitis C case reporting,the reporting rate and accuracy of HCV RNA positive cases in county-level hospitals in China had been greatly improved.By combining the number of HCV antibody tests and the number of viral nucleic acid tests in medical institutions around the country,it was possible to effectively assess the current status of hepatitis C in China and to provide a scientific basis for the development of hepatitis C prevention and treatment measures.
