Capacity analysis is a fundamental and important issue for continuous phase modulation (CPM) signals. In the letter, we investigate the capacity formula of CPM MIMO systems. Using Finite State Machine (FSM), the CPM s...Capacity analysis is a fundamental and important issue for continuous phase modulation (CPM) signals. In the letter, we investigate the capacity formula of CPM MIMO systems. Using Finite State Machine (FSM), the CPM symbols can be modeled as Markov source by combining channel and CPM modulation. Thus the capacity of CPM signals can be derived in form of the erroneous probability and normalized CPM bandwidth. In addition, the capacity of CPM MIMO systems is derived over Gaussian channels and Rayleigh channels. Finally, numerical simulations are implemented according to various parameters such as modulation scheme, modulation index h, memory length L, and antenna configuration.展开更多
The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role i...The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection.展开更多
文摘Capacity analysis is a fundamental and important issue for continuous phase modulation (CPM) signals. In the letter, we investigate the capacity formula of CPM MIMO systems. Using Finite State Machine (FSM), the CPM symbols can be modeled as Markov source by combining channel and CPM modulation. Thus the capacity of CPM signals can be derived in form of the erroneous probability and normalized CPM bandwidth. In addition, the capacity of CPM MIMO systems is derived over Gaussian channels and Rayleigh channels. Finally, numerical simulations are implemented according to various parameters such as modulation scheme, modulation index h, memory length L, and antenna configuration.
基金100 Talent Program of the Chinese Academy of Sciences,the National Natu-ral Science Foundation of China(Grant Nos.81160190,91029707,31170868,812111134 and 31100622)Shanghai Natural Science foun-dation(No.11ZR1442600)+1 种基金SA-SIBS Scholarship Program,Chinese Post-doctoral Science Foundation(No.20110490752)Post-doctoral research foundation of Shanghai Institutes for Biological Sciences(No.2011KIP513).
文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection.
