A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corre...A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results （up to 〉99% conversion, 〉99% ee and TON up to 200 000）. DFT calculations suggest an activating model involving an alkali cation Li.展开更多
Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with mol...Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with molecular hydrogen.Catalyzed by a rhodium/Zhaophos complex,a variety of enones with five-,six-or seven-member ring were hydrogenated with high enantioselectivity(92%-99%ee).Excellent chemo-and enantioselectivity demonstrated this method was successfully applied in the enantioselective hydrogenation of citral to produce enantio-enriched citronellal.展开更多
文摘A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide （f-Amphamide） ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results （up to 〉99% conversion, 〉99% ee and TON up to 200 000）. DFT calculations suggest an activating model involving an alkali cation Li.
基金This project was financially supported by the Science,Technology and Innovation Commission of Shenzhen(Nos.KQTD20150717103157174,JCYJ20170817104350391)the National Natural Science Foundation of China(No.21801118)the Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002).
文摘Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with molecular hydrogen.Catalyzed by a rhodium/Zhaophos complex,a variety of enones with five-,six-or seven-member ring were hydrogenated with high enantioselectivity(92%-99%ee).Excellent chemo-and enantioselectivity demonstrated this method was successfully applied in the enantioselective hydrogenation of citral to produce enantio-enriched citronellal.
