POV-based molecular catalysts for highly efficient esterification of alcohols with aldehydes as acylating agents

The selective oxidative esterification of aldehydes with alcohols to the corresponding esters has been one of the hot spots in scientific research and industrial synthesis.However,the application of precious metal catalytic systems is limited by their complicated synthetic steps and high cost.Thus a highly efficient,green,recyclable selective synthesis method of esters catalyzed by polyoxovanadate(POV)-based molecu-lar catalysts has been developed in this paper.The results show that supramolecular interaction between POV and 1,3-dibenzylimidazolium bromide(Act_(2)Im)can efficiently convert alcohols and aldehydes to the corresponding esters in high yield under much milder conditions.Mechanistic insight is also provided based on the control experiments,single crystal X-ray diffraction and cyclic voltammetry studies.

Reducing obesity and inflammation in mice with organically-derivatized polyoxovanadate clusters

Obesity,characterized by the dysregulation of energy balance in adipose tissue and other metabolic organs,is frequently accompanied by chronic low-grade inflammation.As long-acting insulin sensitizers,the organically-derivatized polyoxovanadates(POVs),can extend the dosing interval of antidiabetic drugs from hourly to almost daily.In this work,the protective activity of POVs is investigated by an eight-week in vivo experiment,in which a small amount of POVs was administrated orally to a mouse model of dietinduced obesity every day.The present study shows that administration of POVs significantly decreases the body weight of mice,reduces adipose tissue accumulation,and simultaneously reduces adipose tissue inflammation.In addition,the anti-obesogenic population of i NKT cells is protected potentially by POVs,which subsequently alleviates visceral adipose tissue inflammation in high-fat-diet(HFD)-fed mice against diet-induced obesity.By contrast,the change in body weight after POV treatment is the result of a substantial reduction in fat mass,with no obvious effects on lean body mass.These findings demonstrate that supplementary of POVs would be an effective way to combat obesity and metabolic disorders while lowering metabolic inflammation.