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Atomic Valley Filter Effect Induced by an Individual Flower Defect in Graphene
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作者 张钰 刘榕 +4 位作者 周丽丽 张璨 杨国元 王业亮 何林 《Chinese Physics Letters》 SCIE EI CAS CSCD 2023年第9期66-70,共5页
Owing to the bipartite nature of honeycomb lattice,the electrons in graphene host valley degree of freedom,which gives rise to a rich set of unique physical phenomena including chiral tunneling,Klein paradox,and quant... Owing to the bipartite nature of honeycomb lattice,the electrons in graphene host valley degree of freedom,which gives rise to a rich set of unique physical phenomena including chiral tunneling,Klein paradox,and quantum Hall ferromagnetism.Atomic defects in graphene can efficiently break the local sublattice symmetry,and hence,have significant effects on the valley-based electronic behaviors.Here we demonstrate that an individual flower defect in graphene has the ability of valley filter at the atomic scale.With the combination of scanning tunneling microscopy and Landau level measurements,we observe two valley-polarized density-of-states peaks near the outside of the flower defects,implying the symmetry breaking of the K and K′valleys in graphene.Moreover,the electrons in the K valley can highly penetrate inside the flower defects.In contrast,the electrons in the K′valley cannot directly penetrate,instead,they should be assisted by the valley switch from the K′to K.Our results demonstrate that an individual flower defect in graphene can be regarded as a nanoscale valley filter,providing insight into the practical valleytronics. 展开更多
关键词 TUNNELING SYMMETRY hence
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腺病毒介导IL-1ra基因对小鼠局灶性脑缺血模型中ICAM-1表达抑制作用 被引量:1
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作者 葛海良 徐龙 +1 位作者 Wen YE guoyuan yang 《中国神经免疫学和神经病学杂志》 CAS 2001年第1期16-19,共4页
目的 IL 1可诱导内皮细胞粘附分子表达 ,促进缺血部位炎症和局部细胞损伤 ,应用腺病毒介导IL 1ra基因观察其对小鼠局灶性脑缺血后内皮细胞ICAM 1蛋白表达的抑制作用。方法 构建携带外源性基因、复制缺陷的人腺病毒 ,并将其作为载体介... 目的 IL 1可诱导内皮细胞粘附分子表达 ,促进缺血部位炎症和局部细胞损伤 ,应用腺病毒介导IL 1ra基因观察其对小鼠局灶性脑缺血后内皮细胞ICAM 1蛋白表达的抑制作用。方法 构建携带外源性基因、复制缺陷的人腺病毒 ,并将其作为载体介导IL 1ra基因、EcoliLacZ基因或以生理盐水分别注射于成年CD 1小鼠右侧脑室。 5d后 ,对实验小鼠分别进行脑血管腔内栓塞术 ,造成持续性中动脉栓塞 ,缺血程度由激光多普勒流量仪确定。采用组织病理切片观察病灶部位白细胞浸润和炎症反应现象 ,免疫组化染色测定血管内皮细胞ICAM 1蛋白表达和用Western印迹进行定量分析。结果 病灶侧皮质区血管内皮细胞ICAM 1蛋白表达量在IL 1ra基因组有明显下降且局部炎症反应轻微 ,与LacZ基因组和生理盐水组比较差异有显著性。ICAM 1蛋白定量分析表明 ,前组比后两组下降 5 0 %左右。但正常侧和病灶侧的脑基质神经节区无明显差异。结论 IL 1ra基因表达蛋白通过抑制IL 1的生物学功能 ,明显下调脑缺血皮质区ICAM 1蛋白表达 ,有助于减轻局部炎症。 展开更多
关键词 基因治疗 IL-1受体拮抗剂 细胞间粘附分子-1 大脑中动脉栓塞
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