Background.Eccrine porocarcinoma (EP) is a rare malignant tumour arising in the acrosyringium, with about 50%of the cases developing local recurrence or metastatic disease.No standard therapy protocols for metastatic ...Background.Eccrine porocarcinoma (EP) is a rare malignant tumour arising in the acrosyringium, with about 50%of the cases developing local recurrence or metastatic disease.No standard therapy protocols for metastatic disease exist.In the past, only short remissions were achieved by applying combinations of cytotoxic agents, which were associated with severe side-effects.Aim of the study.In the case reported here, the aim was to find a protocol with fewer side-effects for a patient who was not willing to undergo extensive polychemotherapy.Subject.A 67-year-old male patient with local recurrence and regional lymph node metastases after resection of EP was treated with a combination of interferon-alpha (IFN-α) 9 million units s.c.three times per week and paclitaxel 100 mg/m2 weekly i.v., which shows a side-effect profile similar to taxotere and is used in the treatment of a variety of neoplasms such as advanced squamous cell carcinoma.Main outcome.This less aggressive treatment was tolerated well and the patient responded with minor remission and long-term stable disease.展开更多
The presence of ectopic breast tissue is reported in 2- 6% of the general population with most cases being located in the axillary region. Although the same pathology occurs in both eutopic and ectopic breast tissue, ...The presence of ectopic breast tissue is reported in 2- 6% of the general population with most cases being located in the axillary region. Although the same pathology occurs in both eutopic and ectopic breast tissue, primary carcinoma of ectopic breast tissue has been reported only in a small number of cases. Because an overlying accessory areola or nipple is often missing and because of a general lack of awareness among physicians and patients concerning these unsuspicious nodules, clinical diagnosis is frequently delayed. Histological diagnosis can also be delayed if ectopic breast tissue is not present or screened for in the biopsy specimens as apocrine glands of the breast and skin, respectively, exhibit striking similarities and immunohistochemistry is of limited help. Diagnostic delay is demonstrated by the case of a 56-year-old patient who underwent a series of four surgical excisions of a primary ectopic breast carcinoma and developed local lymph node metastasis until treatment with tamoxifen was started. As two-thirds of reported cases of primary ectopic breast carcinoma arose within the axillae, this case underlines the importance of a search for ectopic breast tissue in the context of axillary ductal carcinoma.展开更多
文摘Background.Eccrine porocarcinoma (EP) is a rare malignant tumour arising in the acrosyringium, with about 50%of the cases developing local recurrence or metastatic disease.No standard therapy protocols for metastatic disease exist.In the past, only short remissions were achieved by applying combinations of cytotoxic agents, which were associated with severe side-effects.Aim of the study.In the case reported here, the aim was to find a protocol with fewer side-effects for a patient who was not willing to undergo extensive polychemotherapy.Subject.A 67-year-old male patient with local recurrence and regional lymph node metastases after resection of EP was treated with a combination of interferon-alpha (IFN-α) 9 million units s.c.three times per week and paclitaxel 100 mg/m2 weekly i.v., which shows a side-effect profile similar to taxotere and is used in the treatment of a variety of neoplasms such as advanced squamous cell carcinoma.Main outcome.This less aggressive treatment was tolerated well and the patient responded with minor remission and long-term stable disease.
文摘The presence of ectopic breast tissue is reported in 2- 6% of the general population with most cases being located in the axillary region. Although the same pathology occurs in both eutopic and ectopic breast tissue, primary carcinoma of ectopic breast tissue has been reported only in a small number of cases. Because an overlying accessory areola or nipple is often missing and because of a general lack of awareness among physicians and patients concerning these unsuspicious nodules, clinical diagnosis is frequently delayed. Histological diagnosis can also be delayed if ectopic breast tissue is not present or screened for in the biopsy specimens as apocrine glands of the breast and skin, respectively, exhibit striking similarities and immunohistochemistry is of limited help. Diagnostic delay is demonstrated by the case of a 56-year-old patient who underwent a series of four surgical excisions of a primary ectopic breast carcinoma and developed local lymph node metastasis until treatment with tamoxifen was started. As two-thirds of reported cases of primary ectopic breast carcinoma arose within the axillae, this case underlines the importance of a search for ectopic breast tissue in the context of axillary ductal carcinoma.