项目介绍特拉维夫市滨海漫步道位于这个年轻的包豪斯建筑城中心,自20世纪30年代末以来,在建立适应城市与海岸间不断变化的连接关1特拉维夫市中心滨海漫步道规划总平面图Master plan of Tel Aviv’s central promenade系中发挥了关键性...项目介绍特拉维夫市滨海漫步道位于这个年轻的包豪斯建筑城中心,自20世纪30年代末以来,在建立适应城市与海岸间不断变化的连接关1特拉维夫市中心滨海漫步道规划总平面图Master plan of Tel Aviv’s central promenade系中发挥了关键性作用。在滨海漫步道至今所有的使用阶段中,城市与沙滩之间的联系均通过架空栈道完成。目前的更新项目旨在将滨海区域创造成一个能让人在沙滩自由穿梭的新连续界面,以此来改善原有的封闭空间。展开更多
Skin cancer, including both melanoma and non-melanoma, is the most common type of malignancy, which causes substantial morbidities and mortalities. Although the significant increase in the understanding of skin cancer...Skin cancer, including both melanoma and non-melanoma, is the most common type of malignancy, which causes substantial morbidities and mortalities. Although the significant increase in the understanding of skin cancer formation and the development of novel personalized drug regimens have occurred, new treatment options are always of need. The use of natural compounds to alleviate the symptoms or even to prevent and treat cancer has long been proposed. Specifically, the use of marine-based organisms as a source for cancer cure and remedy is being evaluated extensively. The objective of the current study was to assess the ability of the green microalgae Dunaliella salina, the Dead-Sea-derived Haloferax volcanii, and its combinations to treat skin cancer in vitro. The results demonstrate the Dunaliella and Haloferax can reduce sarcoma and basal cell carcinoma cellular growth. Importantly, their combination acts synergistically in a caspase-3 independent manner. Moreover, a synergistic action was found when evaluated sarcoma cell invasion rate, which was completely blocked at pharmacological relevant amounts of the compounds. Collectively, the results demonstrate that the combination of Haloferax volcanii and Dunaliella salina can be used as a new treatment for skin cancer. The specific mechanism of action and further in vivo validation studies are of need.展开更多
文摘项目介绍特拉维夫市滨海漫步道位于这个年轻的包豪斯建筑城中心,自20世纪30年代末以来,在建立适应城市与海岸间不断变化的连接关1特拉维夫市中心滨海漫步道规划总平面图Master plan of Tel Aviv’s central promenade系中发挥了关键性作用。在滨海漫步道至今所有的使用阶段中,城市与沙滩之间的联系均通过架空栈道完成。目前的更新项目旨在将滨海区域创造成一个能让人在沙滩自由穿梭的新连续界面,以此来改善原有的封闭空间。
文摘Skin cancer, including both melanoma and non-melanoma, is the most common type of malignancy, which causes substantial morbidities and mortalities. Although the significant increase in the understanding of skin cancer formation and the development of novel personalized drug regimens have occurred, new treatment options are always of need. The use of natural compounds to alleviate the symptoms or even to prevent and treat cancer has long been proposed. Specifically, the use of marine-based organisms as a source for cancer cure and remedy is being evaluated extensively. The objective of the current study was to assess the ability of the green microalgae Dunaliella salina, the Dead-Sea-derived Haloferax volcanii, and its combinations to treat skin cancer in vitro. The results demonstrate the Dunaliella and Haloferax can reduce sarcoma and basal cell carcinoma cellular growth. Importantly, their combination acts synergistically in a caspase-3 independent manner. Moreover, a synergistic action was found when evaluated sarcoma cell invasion rate, which was completely blocked at pharmacological relevant amounts of the compounds. Collectively, the results demonstrate that the combination of Haloferax volcanii and Dunaliella salina can be used as a new treatment for skin cancer. The specific mechanism of action and further in vivo validation studies are of need.
