Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneou...Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneous T- cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T- cell lymphomas. Case report. We describe a cutaneous CD8+ squamous T- cell lymphoma with polymorphic clinical features, strongly epidermotropic lymphoid infiltrate and spongiosis, classical for this type of lymphoma. Discussion. Bullous lesions in cutaneous T- cell lymphoma should evoke the possibilityofacutaneousCD8+ T- celllymphoma,onceotherbullous diseases have been excluded. Spongiosis, rare in other types of T- cell lymphoma, and strongly epidermotropic pleomorphic lymphoid infiltrate are classical histological features. The association of polymorphic lesions, bullas and atypical CD8+ epidermotropic phenotype should evoke this diagnosis even at the early stage. Treatment is difficult and classical chemotherapy often fails. Prognosis is poor with a mean overall survival of 32 months.展开更多
文摘Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneous T- cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T- cell lymphomas. Case report. We describe a cutaneous CD8+ squamous T- cell lymphoma with polymorphic clinical features, strongly epidermotropic lymphoid infiltrate and spongiosis, classical for this type of lymphoma. Discussion. Bullous lesions in cutaneous T- cell lymphoma should evoke the possibilityofacutaneousCD8+ T- celllymphoma,onceotherbullous diseases have been excluded. Spongiosis, rare in other types of T- cell lymphoma, and strongly epidermotropic pleomorphic lymphoid infiltrate are classical histological features. The association of polymorphic lesions, bullas and atypical CD8+ epidermotropic phenotype should evoke this diagnosis even at the early stage. Treatment is difficult and classical chemotherapy often fails. Prognosis is poor with a mean overall survival of 32 months.
