Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and mortality.The intricate pathological mechanisms underlying IS complicat...Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and mortality.The intricate pathological mechanisms underlying IS complicate the development of effective therapeutic interventions.Ferroptosis,a form of programmed cell death(PCD)characterized by iron overload and accumulation of lipid peroxidation products,has been increasingly recognized as a key contributor to IS pathology.Traditional Chinese medicines(TCMs)have long been utilized in the management of IS,prompting extensive research into their potential as sources of natural ferroptosis inhibitors.This review investigates the critical role of ferroptosis in IS and provides a comprehensive analysis of current research on natural ferroptosis inhibitors identified in TCMs,aiming to lay a theoretical groundwork for the development of innovative anti-IS therapies.展开更多
基金supported by the Natural Science Foundation of Ningxia Province (No.2022AAC02029)the Open Project of Ningxia Key Laboratory of Pharmaceuticals Creation and Generic Medicine Research (No.XZ2020010)the Key Research and Development Plan of Ningxia Hui Autonomous Region (No.2022BFH02012).
文摘Ischemic stroke(IS)is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion,leading to significant morbidity and mortality.The intricate pathological mechanisms underlying IS complicate the development of effective therapeutic interventions.Ferroptosis,a form of programmed cell death(PCD)characterized by iron overload and accumulation of lipid peroxidation products,has been increasingly recognized as a key contributor to IS pathology.Traditional Chinese medicines(TCMs)have long been utilized in the management of IS,prompting extensive research into their potential as sources of natural ferroptosis inhibitors.This review investigates the critical role of ferroptosis in IS and provides a comprehensive analysis of current research on natural ferroptosis inhibitors identified in TCMs,aiming to lay a theoretical groundwork for the development of innovative anti-IS therapies.
