Yersinia pestis is the causative agent of bubonic and pneumonic plagues. Strains of Y. pestis are classified into four biovars： antiqua, mediaevalis, orientalis, and microtus[11. There are two microtus-related plague...Yersinia pestis is the causative agent of bubonic and pneumonic plagues. Strains of Y. pestis are classified into four biovars： antiqua, mediaevalis, orientalis, and microtus[11. There are two microtus-related plague loci in China： the Microtus brandti plague focus in the Xilin Gol Grassland （focus L） and the Microtus fuscus plague focus in the Ojnghai-Tibet Plateau （focus M）.展开更多
Lean body mass(LBM) and age at menarche(AAM) are two important complex traits for human health.The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association...Lean body mass(LBM) and age at menarche(AAM) are two important complex traits for human health.The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study(GWAS).Two studies,a discovery study and a replication study,were performed.In the discovery study,909622 single nucleotide polymorphisms(SNPs) were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform.Then,a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM.In the replication study,significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects.One SNP rs3027009 that was bivariately associated with left arm lean mass and AAM in the discovery samples(P=7.26×10 6) and in the replication samples(P=0.005) was identified.The SNP is located at the upstream of DARC(Duffy antigen receptor for chemokines) gene,suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM.展开更多
基金supported by the Industry Research Special Foundation of China Ministry of Health(No.201202021)
文摘Yersinia pestis is the causative agent of bubonic and pneumonic plagues. Strains of Y. pestis are classified into four biovars： antiqua, mediaevalis, orientalis, and microtus[11. There are two microtus-related plague loci in China： the Microtus brandti plague focus in the Xilin Gol Grassland （focus L） and the Microtus fuscus plague focus in the Ojnghai-Tibet Plateau （focus M）.
基金supported by the Shanghai Leading Academic Discipline Project(Grant No.S30501)a start-up fund from the Shanghai University of Science and Technology,China+1 种基金supported by grants from National Institutes of Health(Grant Nos.P50AR055081, R01AG026564,R01AR050496,RC2DE020756,R01AR057049,and R03TW008221)supported by the National Natural Science Foundation of China(Grant No.31100902)
文摘Lean body mass(LBM) and age at menarche(AAM) are two important complex traits for human health.The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study(GWAS).Two studies,a discovery study and a replication study,were performed.In the discovery study,909622 single nucleotide polymorphisms(SNPs) were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform.Then,a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM.In the replication study,significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects.One SNP rs3027009 that was bivariately associated with left arm lean mass and AAM in the discovery samples(P=7.26×10 6) and in the replication samples(P=0.005) was identified.The SNP is located at the upstream of DARC(Duffy antigen receptor for chemokines) gene,suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM.
