Ultra-Wide Bandwidth(UWB)localization based on time of arrival(TOA)and angle of arrival(AOA)has attracted increasing interest owing to its high accuracy and low cost.However,existing localization methods often fail to...Ultra-Wide Bandwidth(UWB)localization based on time of arrival(TOA)and angle of arrival(AOA)has attracted increasing interest owing to its high accuracy and low cost.However,existing localization methods often fail to achieve satisfactory accuracy in realistic environments due to multipath effects and non-line-of-sight(NLOS)propagation.In this paper,we propose a passive anchor assisted localization(PAAL)scheme,where the active anchor obtains TOA/AOA measurements to the agent while the passive anchors capture the signals from the active anchor and agent.The proposed method fully exploits the time-difference-of-arrival(TDOA)information from the measurements at the passive anchors to complement single-anchor joint TOA/AOA localization.The performance limits of the PAAL system are derived as a benchmark via the information inequality.Moreover,we implement the PAAL system on a low-cost UWB platform,which can achieve 20 cm localization accuracy in NLOS environments.展开更多
The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic...The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory cascade.The decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating neuroinflammation.To combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with C-176.Nanoparticles are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic structures.Our work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor synergistically.In conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.展开更多
Long-range magnetic orders in atomically thin ferromagnetic CrI3 trigger new fascinating physics and application perspectives.The physical properties of two-dimensional(2D)ferromagnetism CrI3 are significantly influen...Long-range magnetic orders in atomically thin ferromagnetic CrI3 trigger new fascinating physics and application perspectives.The physical properties of two-dimensional(2D)ferromagnetism CrI3 are significantly influenced by interlayer spacing and stacking order,which are sensitive to the hydrostatic pressure and external environments.However,there remains debate on the stacking order at low temperature.Here,we study the interlayer coupling and stacking order of non-encapsulated 2–5 layer and bulk CrI3 at 10 K by Raman spectroscopy;demonstrate a rhombohedral stacking in both antiferromagnetic and ferromagnetic CrI3.The opposite helicity dependence of Ag and Eg modes arising from phonon symmetry further validates the rhombohedral stacking.An anomalous temperature-dependent behavior is observed due to spin-phonon coupling below 60 K.Our study provides insights into the interlayer coupling and stacking orders of 2D ferromagnetic materials.展开更多
Exploring the fine-structure of cesium lead bromide(CsPbBr3)perovskite nanocrystals(NCs)is not only vital to fundamental understanding of recombination mechanism of exciton but also crucial for improving the performan...Exploring the fine-structure of cesium lead bromide(CsPbBr3)perovskite nanocrystals(NCs)is not only vital to fundamental understanding of recombination mechanism of exciton but also crucial for improving the performance of quantum light emitters and spintronic devices Herein,utilizing low-temperature magneto-photoluminescence(PL)measurement,we provide the direct PL spectral feature of the dark exciton in CsPbBr3 single crystal,and demonstrate that the singlet dark exciton is located^20 meV below the triplet bright exciton.Furthermore,no significant polarization effect was measured from magnetic-polarization method,indicating that there is no spin selectivity for dark exciton.展开更多
FeSiAlCr alloy powders were prepared by mechanical alloying, the milling time were 20 h, 40 h, 60 h and 80 h, respectively. Powders morphology was studied by SEM. Microstructure of powders milled for various times wer...FeSiAlCr alloy powders were prepared by mechanical alloying, the milling time were 20 h, 40 h, 60 h and 80 h, respectively. Powders morphology was studied by SEM. Microstructure of powders milled for various times were analyzed by XRD. The complex permittivity and complex permeability of four powders were tested in the frequency range from 0.5 to 18 GHz, and their microwave absorption properties were analyzed. It was found that the particle size of powders milled for 80 h was less than 2 μm. Silicon and aluminum atoms were dissolved into the crystal lattice of iron, and chromium atoms can form alloy with iron atoms. The minimum peak value of reflectivity can reach to -11.3 dB at the frequency of 4.3 GHz for 80 h milling powders, and the other one was ?6 dB at 16.5 GHz.展开更多
Magnetoplasmonic sensors are attractive candidates for ultrasensitive chemical and biomedical sensor applications.A variety of ferromagnetic metal thin films have been used for magnetoplasmonic device applications, ye...Magnetoplasmonic sensors are attractive candidates for ultrasensitive chemical and biomedical sensor applications.A variety of ferromagnetic metal thin films have been used for magnetoplasmonic device applications, yet the dependence of sensor performance on the optical and magneto-optical properties of ferromagnetic metal materials has been rarely studied. In this work, we report the study of enhanced magneto-optical Kerr effect(MOKE) and sensing performance in Au∕Fe_xCo_(1-x)bilayer magneto-optical surface plasmon resonance(MOSPR) transducers.The optical constants of Fe_xCo_(1-x)(x = 0, 0.29, 0.47, 0.65, and 1) in a sputter-deposited Au∕Fe_xCo_(1-x)device are characterized by the attenuated total internal reflection(ATR) method. Fe_xCo_(1-x)thin films show different MOKEs as a function of the chemical concentration, with the highest transverse MOKE signal observed in Fe_0.7Co_0.3.Index sensing performance is closely related to the material's optical and magneto-optical constants. By studying the sensing performance in the parameter space of the Au∕Fe_xCo_(1-x)bilayer thicknesses, the highest sensitivity is found to be 0.385(theoretical) and 0.306 RIU^(-1)(experimental) in the Au∕Fe_0.7Co_0.3 MOSPR devices. Our research highlights the influence of the optical properties of ferromagnetic material to device sensitivity in MOSPR transducers. The high sensitivity in Au∕Fe_xCo_(1-x)MOSPR devices make these structures attractivecandidates for chemical and biomedical sensing applications.展开更多
文摘Ultra-Wide Bandwidth(UWB)localization based on time of arrival(TOA)and angle of arrival(AOA)has attracted increasing interest owing to its high accuracy and low cost.However,existing localization methods often fail to achieve satisfactory accuracy in realistic environments due to multipath effects and non-line-of-sight(NLOS)propagation.In this paper,we propose a passive anchor assisted localization(PAAL)scheme,where the active anchor obtains TOA/AOA measurements to the agent while the passive anchors capture the signals from the active anchor and agent.The proposed method fully exploits the time-difference-of-arrival(TDOA)information from the measurements at the passive anchors to complement single-anchor joint TOA/AOA localization.The performance limits of the PAAL system are derived as a benchmark via the information inequality.Moreover,we implement the PAAL system on a low-cost UWB platform,which can achieve 20 cm localization accuracy in NLOS environments.
基金the National Natural Science Foundation of China(No.22161132027,82272465,and 52273152)Zhejiang Provincial Natural Science Foundation of China(LY20H060008)+2 种基金the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-006)‘Open Competition to Select the Best Candidates’Key Technology Program for Nucleic Acid Drugs of NCTIB(Grant No.NCTIB2022HS02006)Zhejiang High-Level Young Talent Special Support Plan for Dr.Zhengwei Mao.
文摘The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death.Cell free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory cascade.The decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating neuroinflammation.To combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with C-176.Nanoparticles are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic structures.Our work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor synergistically.In conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.
基金the financial support from the National Natural Science Foundation of China (51602040 and 51872039)the Science and Technology Program of Sichuan (M112018JY0025)the Scientific Research Foundation for New Teachers of UESTC (A03013023601007)
文摘Long-range magnetic orders in atomically thin ferromagnetic CrI3 trigger new fascinating physics and application perspectives.The physical properties of two-dimensional(2D)ferromagnetism CrI3 are significantly influenced by interlayer spacing and stacking order,which are sensitive to the hydrostatic pressure and external environments.However,there remains debate on the stacking order at low temperature.Here,we study the interlayer coupling and stacking order of non-encapsulated 2–5 layer and bulk CrI3 at 10 K by Raman spectroscopy;demonstrate a rhombohedral stacking in both antiferromagnetic and ferromagnetic CrI3.The opposite helicity dependence of Ag and Eg modes arising from phonon symmetry further validates the rhombohedral stacking.An anomalous temperature-dependent behavior is observed due to spin-phonon coupling below 60 K.Our study provides insights into the interlayer coupling and stacking orders of 2D ferromagnetic materials.
基金supported by the National Natural Science Foundation of China(51602040,51872039,51525202 and 51902098)the Science and Technology Program of Sichuan(M112018JY0025)+1 种基金Scientific Research Foundation for New Teachers of UESTC(A03013023601007)the Ministry of Science and Technology of China(MOST,2016YFA0300802)。
文摘Exploring the fine-structure of cesium lead bromide(CsPbBr3)perovskite nanocrystals(NCs)is not only vital to fundamental understanding of recombination mechanism of exciton but also crucial for improving the performance of quantum light emitters and spintronic devices Herein,utilizing low-temperature magneto-photoluminescence(PL)measurement,we provide the direct PL spectral feature of the dark exciton in CsPbBr3 single crystal,and demonstrate that the singlet dark exciton is located^20 meV below the triplet bright exciton.Furthermore,no significant polarization effect was measured from magnetic-polarization method,indicating that there is no spin selectivity for dark exciton.
基金supported by Scientific Research Fund of Sichuan Provincial Education Department (No.08ZA026)The authors are grateful to State Key Laboratory of Electronic Thin Films and Integrated Devices for support of this work(No.KFJJ200815)
文摘FeSiAlCr alloy powders were prepared by mechanical alloying, the milling time were 20 h, 40 h, 60 h and 80 h, respectively. Powders morphology was studied by SEM. Microstructure of powders milled for various times were analyzed by XRD. The complex permittivity and complex permeability of four powders were tested in the frequency range from 0.5 to 18 GHz, and their microwave absorption properties were analyzed. It was found that the particle size of powders milled for 80 h was less than 2 μm. Silicon and aluminum atoms were dissolved into the crystal lattice of iron, and chromium atoms can form alloy with iron atoms. The minimum peak value of reflectivity can reach to -11.3 dB at the frequency of 4.3 GHz for 80 h milling powders, and the other one was ?6 dB at 16.5 GHz.
基金Ministry of Science and Technology of the People’s Republic of China(MOST)(2016YFA0300802)National Natural Science Foundation of China(NSFC)(51522204,61475031)+4 种基金Fundamental Research Funds for the Central Universities(ZYGX2014Z001)Science Foundation for Youths of Sichuan Province(2015JQO014)Doctoral Fund of Ministry of Education of China(20130185120009)Open Foundation of Key Laboratory ofMultispectral Absorbing Materials and Structures,Ministry of Education(ZYGX2013K007-5)Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT)
文摘Magnetoplasmonic sensors are attractive candidates for ultrasensitive chemical and biomedical sensor applications.A variety of ferromagnetic metal thin films have been used for magnetoplasmonic device applications, yet the dependence of sensor performance on the optical and magneto-optical properties of ferromagnetic metal materials has been rarely studied. In this work, we report the study of enhanced magneto-optical Kerr effect(MOKE) and sensing performance in Au∕Fe_xCo_(1-x)bilayer magneto-optical surface plasmon resonance(MOSPR) transducers.The optical constants of Fe_xCo_(1-x)(x = 0, 0.29, 0.47, 0.65, and 1) in a sputter-deposited Au∕Fe_xCo_(1-x)device are characterized by the attenuated total internal reflection(ATR) method. Fe_xCo_(1-x)thin films show different MOKEs as a function of the chemical concentration, with the highest transverse MOKE signal observed in Fe_0.7Co_0.3.Index sensing performance is closely related to the material's optical and magneto-optical constants. By studying the sensing performance in the parameter space of the Au∕Fe_xCo_(1-x)bilayer thicknesses, the highest sensitivity is found to be 0.385(theoretical) and 0.306 RIU^(-1)(experimental) in the Au∕Fe_0.7Co_0.3 MOSPR devices. Our research highlights the influence of the optical properties of ferromagnetic material to device sensitivity in MOSPR transducers. The high sensitivity in Au∕Fe_xCo_(1-x)MOSPR devices make these structures attractivecandidates for chemical and biomedical sensing applications.