ADC、eADC和rADC值对TIC Ⅱ型、BI-RADS4类乳腺肿瘤良恶性鉴别诊断价值

目的 探讨扩散加权成像定量参数表观扩散系数、指数表观扩散系数和相对表观扩散系数在TIC Ⅱ型、BI-RADS 4类乳腺肿瘤良恶性鉴别诊断中的价值。方法 回顾性分析我院经磁共振诊断为TICⅡ型、BI-RADS 4类的乳腺肿瘤74例,分别计算病灶的ADC、eADC和r ADC值。采用ROC曲线分析各参数对良恶性病变的鉴别诊断效能。结果 ADC、eADC和r ADC值在乳腺良恶性病变组间的差异均有统计学意义(P<0.05)。ADC、eADC、rADC1和rADC2值鉴别诊断良恶性病变AUC分别为0.916、0.915、0.759、0.769;以1.22、0.354、0.636和0.617作为ADC、eADC、r ADC1和r ADC2最佳诊断阈值,其诊断的敏感度分别为88.4%、97.7%、69.8%、51.2%,特异度为87.1%、74.2%、74.2%、93.5%。结论 ADC、e ADC和r ADC的定量分析是鉴别诊断TICⅡ型、BI-RADS 4类乳腺良恶性肿瘤的有效手段。

Antitumor activities of D-glucosamine and its derivatives

The growth inhibitory effects of D-glucosamine hydrochloride （GlcNH2-HCl）, D-glucosamine （GlcNH2） and N-acetyl glucosamine （NAG） on human hepatoma SMMC-7721 cells in vitro were investigated. The results showed that GlcNH2.HCl and GlcNH2 resulted in a concentration-dependent reduction in hepatoma cell growth as measured by MTT （3-（4,5-dimethylthiazol- 2-yl）-2,5-diphenyltetrazolium bromide） assay. This effect was accompanied by a marked increase in the proportion of S cells as analyzed by flow cytometry. In addition, human hepatoma SMMC-7721 cells treated with GlcNH2-HCl resulted in the induction of apoptosis as assayed qualitatively by agarose gel electrophoresis. NAG could not inhibit the proliferation of SMMC-7721 cells. GlcNH2-HCl exhibited antitumor activity against Sarcoma 180 in Kunming mice at dosage of 125-500 mg/kg, dose of 250 mg/kg being the best. GlcNH2-HCl at dose of 250 mg/kg could enhance significantly the thymus index, and spleen index and could promote T lymphocyte proliferation induced by ConA. The antitumor effect of GlcNH2-HCl is probably host-mediated and cytocidal.