Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population:A Meta-analysis

Objective This meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome（MS） in the Chinese population.Methods We searched for articles in MEDLINE via PubM ed,EMBASE,HuG E Navigator,CNKI,and Wanfang databases and calculated odds ratios（ORs） with 95% confidence intervals（CIs） to determine the strength of associations in fixed-or random-effects models.Results We included 21 articles in the meta-analysis：17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 controls.We found an increased risk of MS with the ADIPOQ rs2241766 polymorphism in some genetic models（allele model：OR=1.12,95% CI：1.03-1.21;dominant model：OR=1.15,95% CI：1.04-1.28;homozygote model：OR=1.22,95% CI：1.00-1.49） but no association with the ADIPOQ rs266729 polymorphism（allele model：OR=0.98,95% CI：0.82-1.17;dominant model：OR=0.90,95% CI：0.79-1.02;recessive model：OR=1.09,95% CI：0.85-1.39;homozygote model：OR=1.03,95% CI：0.80-1.33）.Conclusion The results of this meta-analysis suggest an association between the ADIPOQ rs2241766 polymorphism and MS in the Chinese population.G allele of ADIPOQ rs2241766 increases the risk of MS.Better designed studies with different ethnic populations and larger sample sizes are needed for assessing the relationship between ADIPOQ rs2241766 and rs266729 polymorphisms and MS in the future.

Association of TCF7L2 and GCG Gene Variants with Insulin Secretion,Insulin Resistance,and Obesity in New-onset Diabetes

This cohort study was designed to evaluate the association of transcription factor 7-like 2 （TCF7L2） and proglucagon gene （GCG） variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus （T2DM） in a rural adult Chinese population. A total of 7,751 non-T2DM participants 〉18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between 3T genotype and the recessive model of TCFTI.2 rs7903146 and increased risk of T2DM [hazard ratio （HR）=4.068, 95% confidence interval （CI）： 1.270-13.026; HR=4.051, 95% CI： 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.

重症医学科物体表面多药耐药菌二氧化氯消毒效果评价

目的 评价二氧化氯消毒剂对重症医学科(ICU)物体表面多药耐药菌的消毒效果。方法 分别采用500 mg/L含氯消毒剂和100 mg/L二氧化氯消毒剂擦拭消毒ICU环境物体表面,对ICU的呼吸机操作面板和按钮、微量泵按钮或面板等高频接触的医疗用品物体表面以及床旁桌、床栏、电脑键盘等其他物体表面擦拭消毒,分别于消毒前及消毒后2 h内采样。比较两组对ICU多药耐药菌(MDRO)的清除效果和杀菌率。结果 消毒前含氯消毒剂组物体表面检出MDRO 24份,二氧化氯消毒剂组物体表面检出MDRO 35份,MDRO检出率分别是22.64%、19.02%,两组MDRO的检出率差异无统计学意义(P=0.460);消毒后含氯消毒剂组检出MDRO 4份,二氧化氯组未检出MDRO,二氧化氯组MDRO的检出率低于含氯消毒剂组(P=0.017),医疗用品物体表面MDRO的检出率无统计学差异(P=0.413),其他物体表面二氧化氯组MDRO的检出率低于含氯消毒剂组(P=0.038)。二氧化氯组杀菌率高于含氯消毒剂组(P=0.033)。结论 二氧化氯消毒剂是一种高效、安全、广谱的强力杀菌剂,能够切断多药耐药菌的接触传播,适合用于医院内多药耐药菌的感染控制。