Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was...Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR.ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis.The migration,invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined.Results:ROR2 expression was high in metastatic TNBC tissues.ROR2 knockdown suppressed the migration,invasion and chemoresistance of TNBC cells.ROR2 overexpression in MDA-MB-435 cells promoted the migration,invasion,and chemoresistance.Moreover,ROR2 knockdown in HC1599 and MDA-MB-435 adriamycin-resistant cells enhanced chemosensitivity to adriamycin.ROR2 could activate PI3K/AKT/mTOR signaling in TNBC cells.Conclusion:ROR2 is upregulated and promotes metastatic phenotypes of TNBC by activating PI3K/AKT/mTOR signaling.展开更多
The magnetic phase diagram of rare-earth perovskite compound,GdScO3,has been investigated by magnetization and heat capacity.The system undergoes an antiferromagnetic phase transition at TN=2.6 K,with an easy axis of ...The magnetic phase diagram of rare-earth perovskite compound,GdScO3,has been investigated by magnetization and heat capacity.The system undergoes an antiferromagnetic phase transition at TN=2.6 K,with an easy axis of magnetization along the a axis.The magnetization measurements show that it exists a spin-flop transition around 0.3 T for the applied field along the a axis.The critical magnetic field for the antiferromagnetic-to-paramagnetic transition is near 3.2 T when temperature approaches zero.By scaling susceptibilities,we presume this point(B=3.2 T,T=0 K)might be a fieldinduced quantum critical point and the magnetic critical fluctuations can even be felt above TN.展开更多
Casing treatment is one possible way of regaining axial compressor operating range. However, most of casing treatments extend the operating range with the cost of efficiency penalty. A new form of multiple cylindrical...Casing treatment is one possible way of regaining axial compressor operating range. However, most of casing treatments extend the operating range with the cost of efficiency penalty. A new form of multiple cylindrical holes casing treatment(MHCT) with pre-swirl blowing for the NASA Rotor-37 has been designed based on profound understanding of the stall inception. Unsteady numerical simulations have been performed for Rotor-37 with and without MHCT. Parametric studies of the total extraction holes area and their axial locations show that the compressor performance deteriorates as the area ratio increases but the stall margin is extended and there is an optimum extraction holes axial location for stall margin extending. The better configuration of MHCT could extend the stall margin by 6.2% with only 0.23% peak efficiency reduction. Detailed analysis of the physical mechanism behind the stall margin improvement shows that the casing treatment could eliminate the passage blockage by suppressing breakup of tip leakage vortex and decrease the blade load in tip region, which both contribute to improve stall margin of transonic axial compressors.展开更多
Wedge diffuser is widely used in centrifugal compressors due to its high performance and compact size. This paper is aimed to research the influence of wedge diffuser blade number and divergence angle on centrifugal c...Wedge diffuser is widely used in centrifugal compressors due to its high performance and compact size. This paper is aimed to research the influence of wedge diffuser blade number and divergence angle on centrifugal compressor performance. The impact of wedge diffuser blade number on compressor stage performance is investigated, and then the wedge diffusers with different divergence angle are studied by varying diffuser wedge angle and blade number simultaneously. It is found that wedge diffuser with 27 blades could have about 0.8% higher adiabatic efficiency and 0.14 higher total pressure ratio than the wedge diffuser with 19 blades and the best compressor performance is achieved when diffuser divergence angle is 8.3°.These results could give some advices on centrifugal compressor design.展开更多
基金supported by Medical and Health Research Project of Nanjing Health Science and Technology Development Special Fund(ZKX21040).
文摘Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR.ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis.The migration,invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined.Results:ROR2 expression was high in metastatic TNBC tissues.ROR2 knockdown suppressed the migration,invasion and chemoresistance of TNBC cells.ROR2 overexpression in MDA-MB-435 cells promoted the migration,invasion,and chemoresistance.Moreover,ROR2 knockdown in HC1599 and MDA-MB-435 adriamycin-resistant cells enhanced chemosensitivity to adriamycin.ROR2 could activate PI3K/AKT/mTOR signaling in TNBC cells.Conclusion:ROR2 is upregulated and promotes metastatic phenotypes of TNBC by activating PI3K/AKT/mTOR signaling.
基金The work at SUSTech was supported by the National Natural Science Foundation of China(Grant No.11974157)Part of this work was also supported by the National Natural Science Foundation of China(Grant No.11875265)+1 种基金the Scientific Instrument Developing Project of the Chinese Academy of Sciences(3He-based neutron polarization devices)the Institute of High Energy Physics,the Chinese Academy of Sciences.Kan X C and Tian M L were supported by the National Natural Science Foundation of China(Grant No.51802002).
文摘The magnetic phase diagram of rare-earth perovskite compound,GdScO3,has been investigated by magnetization and heat capacity.The system undergoes an antiferromagnetic phase transition at TN=2.6 K,with an easy axis of magnetization along the a axis.The magnetization measurements show that it exists a spin-flop transition around 0.3 T for the applied field along the a axis.The critical magnetic field for the antiferromagnetic-to-paramagnetic transition is near 3.2 T when temperature approaches zero.By scaling susceptibilities,we presume this point(B=3.2 T,T=0 K)might be a fieldinduced quantum critical point and the magnetic critical fluctuations can even be felt above TN.
基金Financial support from the National Natural Science Foundation of China(Project No.51176187 and 51206163)International special cooperation projects(Project No.2014DFR70080)
文摘Casing treatment is one possible way of regaining axial compressor operating range. However, most of casing treatments extend the operating range with the cost of efficiency penalty. A new form of multiple cylindrical holes casing treatment(MHCT) with pre-swirl blowing for the NASA Rotor-37 has been designed based on profound understanding of the stall inception. Unsteady numerical simulations have been performed for Rotor-37 with and without MHCT. Parametric studies of the total extraction holes area and their axial locations show that the compressor performance deteriorates as the area ratio increases but the stall margin is extended and there is an optimum extraction holes axial location for stall margin extending. The better configuration of MHCT could extend the stall margin by 6.2% with only 0.23% peak efficiency reduction. Detailed analysis of the physical mechanism behind the stall margin improvement shows that the casing treatment could eliminate the passage blockage by suppressing breakup of tip leakage vortex and decrease the blade load in tip region, which both contribute to improve stall margin of transonic axial compressors.
文摘Wedge diffuser is widely used in centrifugal compressors due to its high performance and compact size. This paper is aimed to research the influence of wedge diffuser blade number and divergence angle on centrifugal compressor performance. The impact of wedge diffuser blade number on compressor stage performance is investigated, and then the wedge diffusers with different divergence angle are studied by varying diffuser wedge angle and blade number simultaneously. It is found that wedge diffuser with 27 blades could have about 0.8% higher adiabatic efficiency and 0.14 higher total pressure ratio than the wedge diffuser with 19 blades and the best compressor performance is achieved when diffuser divergence angle is 8.3°.These results could give some advices on centrifugal compressor design.
