目的比较肛瘘切开挂线术与括约肌间瘘管结扎术在肛瘘治疗中的临床疗效。方法选取2022年2月—2023年6月郯城县中医医院收治的80例肛瘘患者为研究对象,以随机数表法分为对照组和研究组,每组40例。对照组行肛瘘切开挂线术,研究组行括约肌...目的比较肛瘘切开挂线术与括约肌间瘘管结扎术在肛瘘治疗中的临床疗效。方法选取2022年2月—2023年6月郯城县中医医院收治的80例肛瘘患者为研究对象,以随机数表法分为对照组和研究组,每组40例。对照组行肛瘘切开挂线术,研究组行括约肌间瘘管结扎术。比较两组患者肛门功能、临床指标、生活质量。结果治疗3个月后,研究组耻骨直肠肌(motor unit potential,MUP)时限(6.86±1.23)ms、内括约肌MUP时限(7.19±1.61)ms、外括约肌MUP时限(6.42±1.29)ms均高于对照组,差异有统计学意义(t=3.567、2.386、3.429,P<0.05);研究组各项临床指标均小于对照组,差异有统计学意义(P<0.05),研究组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论括约肌间瘘管结扎术治疗肛瘘疗效较优,有助于改善患者临床各项指标,且对于患者肛门功能影响较小,从而能够提高患者的生活质量。展开更多
To enhance the mechanical and antibacterial properties of silver nanoparticle impregnated cellulosic fibers,carboxy-cellulose nanocrystals(CCNs)were grafted with chitooligosaccharide(COS),which was used as a stabilize...To enhance the mechanical and antibacterial properties of silver nanoparticle impregnated cellulosic fibers,carboxy-cellulose nanocrystals(CCNs)were grafted with chitooligosaccharide(COS),which was used as a stabilizer for silver nanoparticles(AgNPs).Nanofibrous membranes reinforced with silver nanoparticle impregnated cellulosic fibers(CCN-COS-AgNP)were prepared via electrospinning using polyvinyl alcohol(PVA)as a matrix.The effects of CCN-COS-AgNP contents on the morphology,surface composition,mechanical properties,and antibacterial performances of the prepared CCN-COS-AgNP/PVA membranes were examined.The addition of CCN-COS-AgNP certainly improved the mechanical properties and antibacterial performances of the PVA nanofibers.The tensile strength was significantly increased from 4.40 MPa to 8.60 MPa when 8%CCN-COS-AgNP(mass ratio)was introduced.When 10%(mass ratio)CCN-COS-AgNP was added,the nanofibers showed an excellent antibacterial activity for S.aureus(Staphylococcus aureus)and E.coli(Escherichia coli),with the maximum inhibition zones of 2.30 and 1.60 cm,respectively.Moreover,the 2%(mass ratio)CCN-COS-AgNP/PVA fibrous membrane showed 126%cell viability for mg63 human osteoblasts.The electrospun PVA membrane has great potential application in biomedical field.展开更多
文摘目的比较肛瘘切开挂线术与括约肌间瘘管结扎术在肛瘘治疗中的临床疗效。方法选取2022年2月—2023年6月郯城县中医医院收治的80例肛瘘患者为研究对象,以随机数表法分为对照组和研究组,每组40例。对照组行肛瘘切开挂线术,研究组行括约肌间瘘管结扎术。比较两组患者肛门功能、临床指标、生活质量。结果治疗3个月后,研究组耻骨直肠肌(motor unit potential,MUP)时限(6.86±1.23)ms、内括约肌MUP时限(7.19±1.61)ms、外括约肌MUP时限(6.42±1.29)ms均高于对照组,差异有统计学意义(t=3.567、2.386、3.429,P<0.05);研究组各项临床指标均小于对照组,差异有统计学意义(P<0.05),研究组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论括约肌间瘘管结扎术治疗肛瘘疗效较优,有助于改善患者临床各项指标,且对于患者肛门功能影响较小,从而能够提高患者的生活质量。
基金This work was supported by the Natural Science Foundation of Heilongjiang Province,China(No.LH2020C039).
文摘To enhance the mechanical and antibacterial properties of silver nanoparticle impregnated cellulosic fibers,carboxy-cellulose nanocrystals(CCNs)were grafted with chitooligosaccharide(COS),which was used as a stabilizer for silver nanoparticles(AgNPs).Nanofibrous membranes reinforced with silver nanoparticle impregnated cellulosic fibers(CCN-COS-AgNP)were prepared via electrospinning using polyvinyl alcohol(PVA)as a matrix.The effects of CCN-COS-AgNP contents on the morphology,surface composition,mechanical properties,and antibacterial performances of the prepared CCN-COS-AgNP/PVA membranes were examined.The addition of CCN-COS-AgNP certainly improved the mechanical properties and antibacterial performances of the PVA nanofibers.The tensile strength was significantly increased from 4.40 MPa to 8.60 MPa when 8%CCN-COS-AgNP(mass ratio)was introduced.When 10%(mass ratio)CCN-COS-AgNP was added,the nanofibers showed an excellent antibacterial activity for S.aureus(Staphylococcus aureus)and E.coli(Escherichia coli),with the maximum inhibition zones of 2.30 and 1.60 cm,respectively.Moreover,the 2%(mass ratio)CCN-COS-AgNP/PVA fibrous membrane showed 126%cell viability for mg63 human osteoblasts.The electrospun PVA membrane has great potential application in biomedical field.