The Tian Shan Orogenic Belt, which is a subsidiary of the Central Asian Orogenic Belt, is the largest accretion area of continental crust on the Earth during the Phanerozoic. It has experienced several accretionary pr...The Tian Shan Orogenic Belt, which is a subsidiary of the Central Asian Orogenic Belt, is the largest accretion area of continental crust on the Earth during the Phanerozoic. It has experienced several accretionary processes during the Palaeozoic period and has attracted much concern among geologists. An Early Palaeozoic intrusive rock belt extends for 1000 km from east to west, occupying about 40% of the total area within the Kyrgyz Northern Tian Shan Orogenic Belt. Previous studies show that the petrology of these rocks is similar, consisting of granites and granodiorites.展开更多
Objective The Late Paleozoic Southern Tianshan Ocean is usually considered to be the last-closed ocean in the Tianshan Orogeny. However, there is still no consensus if this is indeed the case. Blueschist, eclogite an...Objective The Late Paleozoic Southern Tianshan Ocean is usually considered to be the last-closed ocean in the Tianshan Orogeny. However, there is still no consensus if this is indeed the case. Blueschist, eclogite and ophiolite are present in the Atbashi Range, Kyrgyzstan, which are believed to be the relics of the Southern Tianshan Ocean. New data obtained through Ar-Ar isotopic analysis in this research provide reliable chronological restrictions for this problem.展开更多
目的观察二甲双胍对2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者肝脏炎症、肝纤维化和胰岛素抵抗的影响。方法选取2011年6月至2016年5月收治的70例T2DM合并NAFLG患者,按随机数字表法分为观察组和对照组,每组35例。对照组仅给予...目的观察二甲双胍对2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者肝脏炎症、肝纤维化和胰岛素抵抗的影响。方法选取2011年6月至2016年5月收治的70例T2DM合并NAFLG患者,按随机数字表法分为观察组和对照组,每组35例。对照组仅给予饮食运动治疗,观察组患者在饮食运动疗法上给予二甲双胍,治疗12周后,观察比较2组患者治疗前后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙氨酸转移酶(ALT)和门冬氨酸氨基转移酶(AST)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、层连蛋白(LN)、空腹血糖(FPG)、2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(Fins)及计算胰岛素抵抗指标(HOMA-IR)和不良反应发生情况。结果治疗后2组患者血清中炎症因子指标(TNF-α、IL-6、hs-CRPG)、血脂和肝功能指标(TC、TG、LDL-C、ALT、AST)、肝纤维化指标(PCⅢ、IV-C、LN、HA),血糖及胰岛素指标(FPG、2 h PG、Fins、Hb A1c和HOMA-IR)较治疗前显著降低(P<0.05),且观察组患者上述指标均显著低于对照组(P<0.05),而HDL-C指标显著高于对照组(P<0.05),治疗期间2组患者不良反应发生率比较,差异无统计学意义(χ~2=1.726,P>0.05)。结论二甲双胍能够显著改善T2DM合并NAFLD患者肝脏炎症反应,缓解肝脏纤维化,减轻机体胰岛素抵抗,有利于平稳控制血糖,且不增加患者不良反应。展开更多
文摘The Tian Shan Orogenic Belt, which is a subsidiary of the Central Asian Orogenic Belt, is the largest accretion area of continental crust on the Earth during the Phanerozoic. It has experienced several accretionary processes during the Palaeozoic period and has attracted much concern among geologists. An Early Palaeozoic intrusive rock belt extends for 1000 km from east to west, occupying about 40% of the total area within the Kyrgyz Northern Tian Shan Orogenic Belt. Previous studies show that the petrology of these rocks is similar, consisting of granites and granodiorites.
基金sponsored by the China Geological Survey(grants No.1212011120335 and 12120114006201)
文摘Objective The Late Paleozoic Southern Tianshan Ocean is usually considered to be the last-closed ocean in the Tianshan Orogeny. However, there is still no consensus if this is indeed the case. Blueschist, eclogite and ophiolite are present in the Atbashi Range, Kyrgyzstan, which are believed to be the relics of the Southern Tianshan Ocean. New data obtained through Ar-Ar isotopic analysis in this research provide reliable chronological restrictions for this problem.
文摘目的观察二甲双胍对2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者肝脏炎症、肝纤维化和胰岛素抵抗的影响。方法选取2011年6月至2016年5月收治的70例T2DM合并NAFLG患者,按随机数字表法分为观察组和对照组,每组35例。对照组仅给予饮食运动治疗,观察组患者在饮食运动疗法上给予二甲双胍,治疗12周后,观察比较2组患者治疗前后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙氨酸转移酶(ALT)和门冬氨酸氨基转移酶(AST)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、层连蛋白(LN)、空腹血糖(FPG)、2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(Fins)及计算胰岛素抵抗指标(HOMA-IR)和不良反应发生情况。结果治疗后2组患者血清中炎症因子指标(TNF-α、IL-6、hs-CRPG)、血脂和肝功能指标(TC、TG、LDL-C、ALT、AST)、肝纤维化指标(PCⅢ、IV-C、LN、HA),血糖及胰岛素指标(FPG、2 h PG、Fins、Hb A1c和HOMA-IR)较治疗前显著降低(P<0.05),且观察组患者上述指标均显著低于对照组(P<0.05),而HDL-C指标显著高于对照组(P<0.05),治疗期间2组患者不良反应发生率比较,差异无统计学意义(χ~2=1.726,P>0.05)。结论二甲双胍能够显著改善T2DM合并NAFLD患者肝脏炎症反应,缓解肝脏纤维化,减轻机体胰岛素抵抗,有利于平稳控制血糖,且不增加患者不良反应。
