Background Methamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA ...Background Methamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA use disorder, the indicator of addiction severity is mainly limited to subjective craving score to drug-related cues, which is influenced by many factors such as social approval and self-masking. Aim The present study investigates whether self-reported craving for drug use in response to MA cues is a reliable indicator for addiction severity in MA users, and then tests the validity of the cue-induced attention bias test in addiction severity assessment. Methods Fifty-two male MA users completed the cueinduced craving test and attention bias task, and were required to report clinical characteristics of addiction severity. For the attention bias test, subjects were required to discriminate the letter superimposed onto MA userelated or neutral scenes. The reaction time delay during MA-use condition relative to neutral condition was used as an index of the attention bias. Results The results showed that 24 of the 52 MA users rated non-zero in cue-induced craving test, and they showed a significant attention bias to drug-related pictures. However, the other 28 users who rated zero in cue-induced craving evaluation showed a similar attention bias to drug-related cues. In addition, the attention bias to MA use-related cues was significantly and positively correlated with the clinical indexes of addiction severity, but the relationship was absent between subjective craving evaluation and the indexes of addiction severity. Conclusion These results suggest that attention bias to MA cues may be a more reliable indicator than experiential craving report, especially when subjective craving is measured in the compulsory rehabilitation centre.展开更多
Sandstones attributed to different lacustrine sediment gravity flows are present in the 7th and 6th members of the Yanchang Formation in the Ordos Basin, China. These differences in their origins led to different sand...Sandstones attributed to different lacustrine sediment gravity flows are present in the 7th and 6th members of the Yanchang Formation in the Ordos Basin, China. These differences in their origins led to different sandstone distributions which control the scale and connectivity of oil and gas reservoirs. Numerous cores and outcrops were analysed to understand the origins of these sandstones. The main origin of these sandstones was analysed by statistical methods, and well logging data were used to study their vertical and horizontal distributions. Results show that the sandstones in the study area accu- mulated via sandy debris flows, turbidity currents and slumping, and sandy debris flows predominate. The sand- stone associated with a single event is characteristically small in scale and exhibits poor lateral continuity. How- ever, as a result of multiple events that stacked gravity flow-related sandstones atop one another, sandstones are extensive overall, as illustrated in the cross section and isopach maps. Finally, a depositional model was developed in which sandy debris flows predominated and various other types of small-scale gravity flows occurred frequently, resulting in extensive deposition of sand bodies across a large area.展开更多
Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(...Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(PRD)region using a cavity ring-down spectrometer.Approximately 66.63%,19.28%,and 14.09%of the observed values were filtered as background,pollutant source,and sink due to biospheric uptake,respectively,by applying a robust local regression procedure.Their corresponding mean values were 424.12±10.12 ppm(×10-6 mol mol-1),447.83±13.63 ppm,and 408.83±7.75 ppm.The background XCO2 levels were highest in spring and winter,moderate in autumn,and lowest in summer.The diurnal XCO2 was at a minimum from 1400-1600 LST(Local Standard Time)and a maximum at 0500 LST the next day.The increase of XCO2 in spring and summer was mainly associated with polluted air masses from south coastal Vietnam,the South China Sea,and the southeast Pearl River Estuary.With the exception of summer,airflow primarily from marine regions southeast of Taiwan that passed over the Pearl River Estuary had a greater impact on XCO2,suggesting an important potential source region.展开更多
Objective: To explore the hemostatic mechanism of Jianpi Yiqi Shexue decoction(JYSD) by regulating vascular factors in an immune thrombocytopenia(ITP) mouse model.Methods: An ITP mouse model was established by the pas...Objective: To explore the hemostatic mechanism of Jianpi Yiqi Shexue decoction(JYSD) by regulating vascular factors in an immune thrombocytopenia(ITP) mouse model.Methods: An ITP mouse model was established by the passive-immune modeling method, and interventional drugs used were prednisone tablets and JYSD. The platelet count;vascular activity-related factors v WF, VCAM-1, and TM;and VEGF and b FGF were used as observational indicators.Results: On the 8th day of administration, compared with the model group, platelet counts in the prednisone and JYSD groups increased(both P <.001). Compared with the control group, the levels of v WF, VCAM-1, and TM in the other groups were lower(all P <.05). The VCAM-1 level in the JYSD group was higher than that in the prednisone group(P =.012), but without significant difference compared with the model group(P =.051). The TM level in the JYSD group was the lowest(vs. the model group,P =.047;vs. the prednisone group, P =.006). Compared with the control group, the IOD values of VEGF and b FGF in the other three groups were lower(all P <.01). The IOD values of VEGF in the prednisone and JYSD groups were both higher than those in the model group(P =.002 and P <.001, respectively). The IOD values of b FGF among the model, prednisone, and JYSD groups were not statistically significant(P >.05).Conclusion: A vascular factor disorder is involved in the pathogenesis of ITP. JYSD can increase the platelet count, upregulate VEGF expression, and reduce the TM level. JYSD has the same effect as prednisone tablets in regulating platelet, v WF, VEGF, and b FGF, with a stronger effect in normalizing VCAM-1 and TM levels. The hemostatic mechanism of JYSD is closely related to the effective balance of vascular factors.展开更多
The homomorphic hash algorithm(HHA)is introduced to help on-the-fly verify the vireless sensor network(WSN)over-the-air programming(OAP)data based on rateless codes.The receiver calculates the hash value of a group of...The homomorphic hash algorithm(HHA)is introduced to help on-the-fly verify the vireless sensor network(WSN)over-the-air programming(OAP)data based on rateless codes.The receiver calculates the hash value of a group of data by homomorphic hash function,and then it compares the hash value with the receiving message digest.Because the feedback channel is deliberately removed during the distribution process,the rateless codes are often vulnerable when they face security issues such as packets contamination or attack.This method prevents contaminating or attack on rateless codes and reduces the potential risks of decoding failure.Compared with the SHA1 and MD5,HHA,which has a much shorter message digest,will deliver more data.The simulation results show that to transmit and verify the same amount of OAP data,HHA method sends 17.9% to 23.1%fewer packets than MD5 and SHA1 under different packet loss rates.展开更多
BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other dise...BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other diseases classified elsewhere.However,the exact causal relationships between gut microbiota and the different forms of dementia or their subtypes remain unclear.AIM To investigate putative causal relationships between gut microbiota and dementia or its subtypes using Mendelian randomization(MR)analysis.METHODS A bidirectional,two-sample,MR analysis was conducted utilizing publicly available gut microbiota-related genome-wide association study(GWAS)summary data from the MiBioGen consortium alongside GWAS summary statistics for dementia and its subtypes from the FinnGen consortium.Instrumental variables were selected according to the fundamental tenets of MR and their strengths were evaluated using the F-statistic.Five MR methods were employed,and the robustness of our findings was validated.To account for multiple comparisons,we applied the Bonferroni method for P-value adjustment.RESULTS We identified several gut microbiota taxa exhibiting putative causal relationships with dementia or its subtypes,potentially serving as risk or protective factors for the disease.In addition,reverse MR analysis indicated that the relative abundance of several gut microbiota taxa might be influenced by dementia or its subtypes.An exhaustive sensitivity analysis confirmed the absence of heterogeneity and horizontal pleiotropy.After applying correction for multiple testing,we observed that the order Bacillales(odds ratio:0.830,95%confidence interval:0.740-0.932,P=0.00155,Padjust=0.0311)exhibited a strong association with Alzheimer’s disease-related dementia.CONCLUSION The results suggest that gut microbiota is causally associated with dementia.Our findings provide novel insights into the pathophysiology of dementia and have important implications for its treatment and prevention.展开更多
Accurate segmentation of tumor images is a key core technology for the diagnosis and treatment of tumor diseases.In this paper,we analyze a variety of novel and targeted algorithms to solve these problems,summarize,an...Accurate segmentation of tumor images is a key core technology for the diagnosis and treatment of tumor diseases.In this paper,we analyze a variety of novel and targeted algorithms to solve these problems,summarize,and elaborate the method based on multimodal tumor image processing given the characteristics of serious grayscale inhomogeneity,texture instability,and diversity complexity of tumor images.展开更多
基金National Natural Science Foundation of China (grant no. 3187110331671164).
文摘Background Methamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA use disorder, the indicator of addiction severity is mainly limited to subjective craving score to drug-related cues, which is influenced by many factors such as social approval and self-masking. Aim The present study investigates whether self-reported craving for drug use in response to MA cues is a reliable indicator for addiction severity in MA users, and then tests the validity of the cue-induced attention bias test in addiction severity assessment. Methods Fifty-two male MA users completed the cueinduced craving test and attention bias task, and were required to report clinical characteristics of addiction severity. For the attention bias test, subjects were required to discriminate the letter superimposed onto MA userelated or neutral scenes. The reaction time delay during MA-use condition relative to neutral condition was used as an index of the attention bias. Results The results showed that 24 of the 52 MA users rated non-zero in cue-induced craving test, and they showed a significant attention bias to drug-related pictures. However, the other 28 users who rated zero in cue-induced craving evaluation showed a similar attention bias to drug-related cues. In addition, the attention bias to MA use-related cues was significantly and positively correlated with the clinical indexes of addiction severity, but the relationship was absent between subjective craving evaluation and the indexes of addiction severity. Conclusion These results suggest that attention bias to MA cues may be a more reliable indicator than experiential craving report, especially when subjective craving is measured in the compulsory rehabilitation centre.
基金supported by the Science Foundation Programs(41302115)
文摘Sandstones attributed to different lacustrine sediment gravity flows are present in the 7th and 6th members of the Yanchang Formation in the Ordos Basin, China. These differences in their origins led to different sandstone distributions which control the scale and connectivity of oil and gas reservoirs. Numerous cores and outcrops were analysed to understand the origins of these sandstones. The main origin of these sandstones was analysed by statistical methods, and well logging data were used to study their vertical and horizontal distributions. Results show that the sandstones in the study area accu- mulated via sandy debris flows, turbidity currents and slumping, and sandy debris flows predominate. The sand- stone associated with a single event is characteristically small in scale and exhibits poor lateral continuity. How- ever, as a result of multiple events that stacked gravity flow-related sandstones atop one another, sandstones are extensive overall, as illustrated in the cross section and isopach maps. Finally, a depositional model was developed in which sandy debris flows predominated and various other types of small-scale gravity flows occurred frequently, resulting in extensive deposition of sand bodies across a large area.
基金funded by the National Key R&D Program of China(Grant No.2018YFC0213902,2019YFC0214605,2016YFC0202000)the open project of the Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration,Nanjing University of Information Science and Technology(KDW 1803)+1 种基金the Scientific and Technological Innovation Team Project of Guangzhou Joint Research Center of Atmospheric Sciences,China Meteorological Administration(Grant No.201704)the Science and Technology Research Project of Guangdong Meteorological Bureau(Grant No.GRMC2018M01)。
文摘Mole fractions of atmospheric CO2(XCO2)have been continuously measured from October 2014 to March 2016 at the Guangzhou Panyu Atmospheric Composition Site(23.00°N,113.21°E;140 m MSL)in the Pearl River Delta(PRD)region using a cavity ring-down spectrometer.Approximately 66.63%,19.28%,and 14.09%of the observed values were filtered as background,pollutant source,and sink due to biospheric uptake,respectively,by applying a robust local regression procedure.Their corresponding mean values were 424.12±10.12 ppm(×10-6 mol mol-1),447.83±13.63 ppm,and 408.83±7.75 ppm.The background XCO2 levels were highest in spring and winter,moderate in autumn,and lowest in summer.The diurnal XCO2 was at a minimum from 1400-1600 LST(Local Standard Time)and a maximum at 0500 LST the next day.The increase of XCO2 in spring and summer was mainly associated with polluted air masses from south coastal Vietnam,the South China Sea,and the southeast Pearl River Estuary.With the exception of summer,airflow primarily from marine regions southeast of Taiwan that passed over the Pearl River Estuary had a greater impact on XCO2,suggesting an important potential source region.
基金supported by the National Basic Research Program of China (973 Program, 2013CB531705)the National Natural Science Foundation Youth Project of China(81703903 and 81803904)
文摘Objective: To explore the hemostatic mechanism of Jianpi Yiqi Shexue decoction(JYSD) by regulating vascular factors in an immune thrombocytopenia(ITP) mouse model.Methods: An ITP mouse model was established by the passive-immune modeling method, and interventional drugs used were prednisone tablets and JYSD. The platelet count;vascular activity-related factors v WF, VCAM-1, and TM;and VEGF and b FGF were used as observational indicators.Results: On the 8th day of administration, compared with the model group, platelet counts in the prednisone and JYSD groups increased(both P <.001). Compared with the control group, the levels of v WF, VCAM-1, and TM in the other groups were lower(all P <.05). The VCAM-1 level in the JYSD group was higher than that in the prednisone group(P =.012), but without significant difference compared with the model group(P =.051). The TM level in the JYSD group was the lowest(vs. the model group,P =.047;vs. the prednisone group, P =.006). Compared with the control group, the IOD values of VEGF and b FGF in the other three groups were lower(all P <.01). The IOD values of VEGF in the prednisone and JYSD groups were both higher than those in the model group(P =.002 and P <.001, respectively). The IOD values of b FGF among the model, prednisone, and JYSD groups were not statistically significant(P >.05).Conclusion: A vascular factor disorder is involved in the pathogenesis of ITP. JYSD can increase the platelet count, upregulate VEGF expression, and reduce the TM level. JYSD has the same effect as prednisone tablets in regulating platelet, v WF, VEGF, and b FGF, with a stronger effect in normalizing VCAM-1 and TM levels. The hemostatic mechanism of JYSD is closely related to the effective balance of vascular factors.
基金Supported by the National Science and Technology Support Program(Y2140161A5)the National High Technology Research and Development Program of China(863Program)(O812041A04)
文摘The homomorphic hash algorithm(HHA)is introduced to help on-the-fly verify the vireless sensor network(WSN)over-the-air programming(OAP)data based on rateless codes.The receiver calculates the hash value of a group of data by homomorphic hash function,and then it compares the hash value with the receiving message digest.Because the feedback channel is deliberately removed during the distribution process,the rateless codes are often vulnerable when they face security issues such as packets contamination or attack.This method prevents contaminating or attack on rateless codes and reduces the potential risks of decoding failure.Compared with the SHA1 and MD5,HHA,which has a much shorter message digest,will deliver more data.The simulation results show that to transmit and verify the same amount of OAP data,HHA method sends 17.9% to 23.1%fewer packets than MD5 and SHA1 under different packet loss rates.
基金Supported by Science and Technology Planning Project of Zhanjiang,No.2021A05071Clinic and Basic Research Project of Guangdong Medical University,No.4SG23284GThe Affiliated Hospital of Guangdong Medical University,No.LCYJ2018A003.
文摘BACKGROUND Existing evidence suggests that gut microbiota represent a significant environmental risk factor for various forms of dementia,including Alzheimer's dementia,vascular dementia,and dementia in other diseases classified elsewhere.However,the exact causal relationships between gut microbiota and the different forms of dementia or their subtypes remain unclear.AIM To investigate putative causal relationships between gut microbiota and dementia or its subtypes using Mendelian randomization(MR)analysis.METHODS A bidirectional,two-sample,MR analysis was conducted utilizing publicly available gut microbiota-related genome-wide association study(GWAS)summary data from the MiBioGen consortium alongside GWAS summary statistics for dementia and its subtypes from the FinnGen consortium.Instrumental variables were selected according to the fundamental tenets of MR and their strengths were evaluated using the F-statistic.Five MR methods were employed,and the robustness of our findings was validated.To account for multiple comparisons,we applied the Bonferroni method for P-value adjustment.RESULTS We identified several gut microbiota taxa exhibiting putative causal relationships with dementia or its subtypes,potentially serving as risk or protective factors for the disease.In addition,reverse MR analysis indicated that the relative abundance of several gut microbiota taxa might be influenced by dementia or its subtypes.An exhaustive sensitivity analysis confirmed the absence of heterogeneity and horizontal pleiotropy.After applying correction for multiple testing,we observed that the order Bacillales(odds ratio:0.830,95%confidence interval:0.740-0.932,P=0.00155,Padjust=0.0311)exhibited a strong association with Alzheimer’s disease-related dementia.CONCLUSION The results suggest that gut microbiota is causally associated with dementia.Our findings provide novel insights into the pathophysiology of dementia and have important implications for its treatment and prevention.
基金2022 Scientific Research Project of Anhui Higher Education Institutions(Natural Science),“Construction and Application of Multimodal Medical Tumor Image Segmentation Model Based on Improved U-Net Model”(Project No.2022AH051889).
文摘Accurate segmentation of tumor images is a key core technology for the diagnosis and treatment of tumor diseases.In this paper,we analyze a variety of novel and targeted algorithms to solve these problems,summarize,and elaborate the method based on multimodal tumor image processing given the characteristics of serious grayscale inhomogeneity,texture instability,and diversity complexity of tumor images.
