目的分析青海省2011-2018年疑似预防接种异常反应(adverse events following immunization, AEFI)监测结果,评价青海省AEFI监测质量。方法通过中国AEFI监测管理系统收集2011-2018年青海省AEFI监测资料,采用描述流行病学方法进行分析。结...目的分析青海省2011-2018年疑似预防接种异常反应(adverse events following immunization, AEFI)监测结果,评价青海省AEFI监测质量。方法通过中国AEFI监测管理系统收集2011-2018年青海省AEFI监测资料,采用描述流行病学方法进行分析。结果 2011-2018年青海省报告AEFI个案949例,平均报告发生率为7.52/10万。报告个案中男性526例(55.43%)、女性423例(44.57%),主要集中在3岁组以下,共794例(83.67%);4-9月报告数最多。一般反应最多,共893例(94.10%),异常反应次之,共30例(3.16%)。一般反应中发热最多,异常反应中过敏反应最多。AEFI报告发生率前3位的分别为白破疫苗、百白破疫苗和含麻类疫苗。结论青海省AEFI监测敏感性在增强,但仍需加强AEFI监测的培训和指导。展开更多
Objective:To analyze the factors related to pregnancy of endometriosis and whether Chinese herbal medicines(CHMs)can improve pregnancy outcomes in patients with endometriosis in long-term management.Methods:This multi...Objective:To analyze the factors related to pregnancy of endometriosis and whether Chinese herbal medicines(CHMs)can improve pregnancy outcomes in patients with endometriosis in long-term management.Methods:This multicenter cohort study retrospectively analyzed the clinical data of endometriosis patients with fertility needs from January 2019 to November 2019.A total of 252 patients with endometriosis from 5 level-ⅢGrade A hospitals in Beijing were included in this study.Univariate and multivariate logistic regression analysis were performed for the relevant factors.The propensity score matching(PSM)function of SPSS software was used to match the CHMs group with the non-CHMs group.The pregnancy rate and live birth rate were analyzed.Results:The results of univariate analysis showed that age,disease course,presence of infertility,presence of adenomyosis,time after surgery or use of gonadotropin-releasing hormone agonist(Gn RH-a),use of CHMs and follow-up time were influencing factors of pregnancy in endometriosis patients(P<0.05).The results of multivariate analysis showed that age,presence of adenomyosis,time after surgery or use of GnRH-a,use of CHMs and follow-up time were independent factors affecting pregnancy in endometriosis patients,among which,age 35 years old,presence of adenomyosis and follow-up time>6 months were independent risk factors(OR=0.445,0.348,0.140,respectively,P<0.05),time after surgery or use of Gn RH-a 6 months and use of CHMs were independent protective factors(OR=3.839,3.842,respectively,P<0.05).After PSM,99 pairs of two groups were matched successfully.The pregnancy rate of the CHMs group was higher than that of the non-CHMs group[55.56%(55/99)vs.36.36%(36/99),P<0.05].The live birth rate of the CHMs group was higher than that of the non-CHMs group[49.49%(49/99)vs.35.35%(35/99),P<0.05].Conclusion:CHMs can effectively improve clinical pregnancy rate and live birth rate of patients with endometriosis in the chronic disease management.展开更多
基金Supported by Capital’s Funds for Health Improvement and Research(No.2018-1-4151)Project of"Hundred Thousand"Talents Project of TCM Inheritance and Innovation(Qihuang Project)Qihuang Scholars(Letter[2018]No.284,Department of Human Education,National Administration of Traditional Chinese Medicine)。
文摘Objective:To analyze the factors related to pregnancy of endometriosis and whether Chinese herbal medicines(CHMs)can improve pregnancy outcomes in patients with endometriosis in long-term management.Methods:This multicenter cohort study retrospectively analyzed the clinical data of endometriosis patients with fertility needs from January 2019 to November 2019.A total of 252 patients with endometriosis from 5 level-ⅢGrade A hospitals in Beijing were included in this study.Univariate and multivariate logistic regression analysis were performed for the relevant factors.The propensity score matching(PSM)function of SPSS software was used to match the CHMs group with the non-CHMs group.The pregnancy rate and live birth rate were analyzed.Results:The results of univariate analysis showed that age,disease course,presence of infertility,presence of adenomyosis,time after surgery or use of gonadotropin-releasing hormone agonist(Gn RH-a),use of CHMs and follow-up time were influencing factors of pregnancy in endometriosis patients(P<0.05).The results of multivariate analysis showed that age,presence of adenomyosis,time after surgery or use of GnRH-a,use of CHMs and follow-up time were independent factors affecting pregnancy in endometriosis patients,among which,age 35 years old,presence of adenomyosis and follow-up time>6 months were independent risk factors(OR=0.445,0.348,0.140,respectively,P<0.05),time after surgery or use of Gn RH-a 6 months and use of CHMs were independent protective factors(OR=3.839,3.842,respectively,P<0.05).After PSM,99 pairs of two groups were matched successfully.The pregnancy rate of the CHMs group was higher than that of the non-CHMs group[55.56%(55/99)vs.36.36%(36/99),P<0.05].The live birth rate of the CHMs group was higher than that of the non-CHMs group[49.49%(49/99)vs.35.35%(35/99),P<0.05].Conclusion:CHMs can effectively improve clinical pregnancy rate and live birth rate of patients with endometriosis in the chronic disease management.
