Eight novel arylnaphthalide lactone lignans, designated as diphylignan A-H(1-8), and a new dibenzyltyrolactone lignan, designated as diphylignan I(9), were isolated from the roots and rhizomes of Diphylleia sinensis, ...Eight novel arylnaphthalide lactone lignans, designated as diphylignan A-H(1-8), and a new dibenzyltyrolactone lignan, designated as diphylignan I(9), were isolated from the roots and rhizomes of Diphylleia sinensis, along with two additional novel natural products(11 and 14) and four known metabolites(10, 12, 13, 15). The structural and stereochemical characterization of these compounds was accomplished using NMR spectroscopy and electronic circular dichroism(ECD) analysis. The cytotoxic activities of all isolated compounds were assessed against A-549 and SMMC-7721 cell lines. Notably, compound 2 demonstrated the most significant cytotoxicity, with IC_(50) values of 10.27 and 11.58 μmol·L^(-1) against A-549 and SMMC-7721 cell lines, respectively, exhibiting greater potency than the positive control, cisplatin.展开更多
基金supported by the Key Research Project of Higher Education Institution in Henan Province (No.24A360015)the Scientific and Technological Key Project in Henan Province (No. 192102310438)+1 种基金the Program for Innovative Research Team (in Science and Technology) in University of Henan Province(No. 24IRTSTHN039)the Research Project on Chinese Medicine Science in Henan Province (No. 20-21ZY1039)。
文摘Eight novel arylnaphthalide lactone lignans, designated as diphylignan A-H(1-8), and a new dibenzyltyrolactone lignan, designated as diphylignan I(9), were isolated from the roots and rhizomes of Diphylleia sinensis, along with two additional novel natural products(11 and 14) and four known metabolites(10, 12, 13, 15). The structural and stereochemical characterization of these compounds was accomplished using NMR spectroscopy and electronic circular dichroism(ECD) analysis. The cytotoxic activities of all isolated compounds were assessed against A-549 and SMMC-7721 cell lines. Notably, compound 2 demonstrated the most significant cytotoxicity, with IC_(50) values of 10.27 and 11.58 μmol·L^(-1) against A-549 and SMMC-7721 cell lines, respectively, exhibiting greater potency than the positive control, cisplatin.
