This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical properties.Phytochemical,ethnop...This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical properties.Phytochemical,ethnopharmacological,and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the Ranunculaceae.The chemical components of this family included several representative metabolic groups:benzylisoquinoline alkaloids,ranunculin,triterpenoid saponin,and diterpene alkaloids,among others.Ranunculin and magnoflorine were found to coexist in some genera.The pharmacophylogenetic analysis,integrated with therapeutic information,agreed with the taxonomy proposed previously,in which the family Ranunculaceae was divided into five sub-families:Ranunculoideae,Thalictroideae,Coptidoideae,Hydrastidoideae,and Glaucidioideae.It was plausible to organize the sub-family Ranunculoideae into ten tribes.The chemical constituents and therapeutic efficacy of each taxonomic group were reviewed,revealing the underlying connections between phylogeny,chemical diversity,and clinical use,which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae.展开更多
Medicinal plants have provided numerous medicinal active ingredients for thousands of years and these ingredients have been used in Chinese medicine(CM)and traditional pharmacologies worldwide.Recently,the exploitatio...Medicinal plants have provided numerous medicinal active ingredients for thousands of years and these ingredients have been used in Chinese medicine(CM)and traditional pharmacologies worldwide.Recently,the exploitation and utilisation of medicinal plant resources has increased significantly.The results of the studies have led to the identification of many active components,such as steroidal alkaloids,saponins,terpenoids,and glycosides,in various medicinal plants with different evolutionary levels.Moreover,research on the chemical classification,molecular phylogeny,and pharmacological activity of medicinal plants is increasing in popularity.Pharmacophylogeny is an interdisciplinary topic that studies the correlation between plant phylogeny,chemical composition,and curative effects(pharmacological activity and the traditional curative effect)of medicinal plants.In addition,it provides the basic tools to enable research and development of CM resources.This literature review,based on the genetic relationship between phytogroup and species,highlights the formation process,research content,applications,and future directions of pharmacophylogeny.展开更多
基金supported by the China Scholarship Council(No.201208210122)
文摘This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical properties.Phytochemical,ethnopharmacological,and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the Ranunculaceae.The chemical components of this family included several representative metabolic groups:benzylisoquinoline alkaloids,ranunculin,triterpenoid saponin,and diterpene alkaloids,among others.Ranunculin and magnoflorine were found to coexist in some genera.The pharmacophylogenetic analysis,integrated with therapeutic information,agreed with the taxonomy proposed previously,in which the family Ranunculaceae was divided into five sub-families:Ranunculoideae,Thalictroideae,Coptidoideae,Hydrastidoideae,and Glaucidioideae.It was plausible to organize the sub-family Ranunculoideae into ten tribes.The chemical constituents and therapeutic efficacy of each taxonomic group were reviewed,revealing the underlying connections between phylogeny,chemical diversity,and clinical use,which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae.
基金Supported by the National Natural Science Foundation of China(No.81760776,81874336)Natural Science Foundation of Inner Mongolia Autonomous Region(No.2018ZD134)。
文摘Medicinal plants have provided numerous medicinal active ingredients for thousands of years and these ingredients have been used in Chinese medicine(CM)and traditional pharmacologies worldwide.Recently,the exploitation and utilisation of medicinal plant resources has increased significantly.The results of the studies have led to the identification of many active components,such as steroidal alkaloids,saponins,terpenoids,and glycosides,in various medicinal plants with different evolutionary levels.Moreover,research on the chemical classification,molecular phylogeny,and pharmacological activity of medicinal plants is increasing in popularity.Pharmacophylogeny is an interdisciplinary topic that studies the correlation between plant phylogeny,chemical composition,and curative effects(pharmacological activity and the traditional curative effect)of medicinal plants.In addition,it provides the basic tools to enable research and development of CM resources.This literature review,based on the genetic relationship between phytogroup and species,highlights the formation process,research content,applications,and future directions of pharmacophylogeny.
