2020和2021年在江西省南昌市进行了9.5%丙嗪嘧磺隆SC在15~60 g a.i./hm^(2)处理下及对照药(苄嘧磺隆和五氟磺草胺)的大田杂草防效试验,并评估其对水稻安全性和产量的影响。结果表明,9.5%丙嗪嘧磺隆SC对移栽水稻田稗草和鸭舌草均具有良...2020和2021年在江西省南昌市进行了9.5%丙嗪嘧磺隆SC在15~60 g a.i./hm^(2)处理下及对照药(苄嘧磺隆和五氟磺草胺)的大田杂草防效试验,并评估其对水稻安全性和产量的影响。结果表明,9.5%丙嗪嘧磺隆SC对移栽水稻田稗草和鸭舌草均具有良好的防除效果,60 g a.i./hm^(2)剂量处理后,对稗草的株防效高达92.40%~98.91%,对鸭舌草的株防效为82.62%~89.15%。所有处理对水稻均无药害产生,并实现增产。因此,新型除草剂丙嗪嘧磺隆可有效防除移栽水稻田稗草和鸭舌草,有较好的应用价值。展开更多
Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical p...Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.展开更多
文摘2020和2021年在江西省南昌市进行了9.5%丙嗪嘧磺隆SC在15~60 g a.i./hm^(2)处理下及对照药(苄嘧磺隆和五氟磺草胺)的大田杂草防效试验,并评估其对水稻安全性和产量的影响。结果表明,9.5%丙嗪嘧磺隆SC对移栽水稻田稗草和鸭舌草均具有良好的防除效果,60 g a.i./hm^(2)剂量处理后,对稗草的株防效高达92.40%~98.91%,对鸭舌草的株防效为82.62%~89.15%。所有处理对水稻均无药害产生,并实现增产。因此,新型除草剂丙嗪嘧磺隆可有效防除移栽水稻田稗草和鸭舌草,有较好的应用价值。
基金supported by the National Natural Science Foundation of China(Grant No.21472242)the National Science and Technology Major Project for "Significant New Drugs Creation" of China(Grant No.2015ZX09102001)State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZCX201406)
文摘Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.
